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Volume - 63 , Issue 02
28 Feb 2023

Azerbaijan Medical Journal

(ISSN: 0005-2523)

Azerbaijan medical journal (ISSN: 0005-2523) - is a scopus indexed journal since 1961. The publisher of the journal is Izdatel'stvo Elm by WHO Office in Azerbaijan. Azerbaijan medical journal (AMJ) is also UGC approved. The journal publishes general medicine, health science, psychological, pharmaceutical journals and so on. Gongcheng Kexue Yu Jishu/Advanced Engineering Science Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery Interventional Pulmonology Zhenkong Kexue yu Jishu Xuebao/Journal of Vacuum Science and Technology

Aim and Scope

Azerbaijan Medical Journal

Azerbaijan Medical Journal (ISSN: 0005-2523) - is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to. Zhongguo Shiyou Daxue Xuebao (Ziran Kexue Ban)/Journal of China University of Petroleum (Edition of Natural Science) Tobacco Science and Technology Teikyo Medical Journal Connected Health Wuhan Ligong Daxue Xuebao (Jiaotong Kexue Yu Gongcheng Ban)/Journal of Wuhan University of Technology (Transportation Science and Engineering) Zhonghua yi shi za zhi (Beijing, China : 1980) Agricultural Mechanization in Asia, Africa and Latin America International Medical Journal Technology Reports of Kansai University Asia Life Sciences Open Access Journals Tagliche Praxis

Anatomy Physiology Biochemistry Pharmacology Pathology Forensic medicine Microbiology Community Medicine Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases Anaesthesia Cancer research Neurosurgery Orthopedics Gastroenterology Neurology Nephrology Medical education Orthopaedics Paediatrics Reproduction Cardiology Diabetes Surgery Nursing Otolaryngology Dental Psychology Anesthesiology Dermatology Endocrinology Hepatology Urology Venereology Psychiatry Biotechnology Pharmacy ENT Pharmaceutical Chemistry Pharmaceutical Analysis Pharmaceutics Pulmonology Pharmacognosy Pharmaceutical Phatmaceutical Technology Biopharmaceutics Pharmacokinetics Pharmacodynamics Industrial Pharmacy Drug Design Quality Assurance Drug Regulatory Affairs Phytochemistry Drug Delivery Systems Pharmaceutical Nanotechnology Pharmaceutical Microbiology Hospital Pharmacy Clinical Pharmacy Pharmacy Practice Drug Discovery Drug Metabolism Toxicology Clinical Research Pharmacogenomics Phrmacoinformatics Pharmacovigilance< Life Sciences like Chemistry Biomedical Sciences Microbiology Immunology Forensic Epidemiology Oncology Biomedicine Dentistry Physiotherapy Gynaecology Dermatoepidemiology Neuroscience Ophthalmology Sexology Osteology Kinesiology Angiology/Vascular Medicine Critical care Medicine Haematology Infectious Diseases and Vaccinology Bariatrics Pharmacy and Nursing Pharmacognosy and Phytochemistry Radiobiology Clinical immunology Clinical and Hospital Pharmacy Cell Biology Genomics and Proteomics Healthcare Services Healthcare Management Bioinformatics and Biotechnology Geriatric Medicine Bulletin of National Institute of Health Sciences Journal of the Austrian Society of Agricultural Economics Gongcheng Kexue Yu Jishu/Advanced Engineering Science Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery Interventional Pulmonology Zhenkong Kexue yu Jishu Xuebao/Journal of Vacuum Science and Technology Wuhan Ligong Daxue Xuebao (Jiaotong Kexue Yu Gongcheng Ban)/Journal of Wuhan University of Technology (Transportation Science and Engineering) Zhonghua yi shi za zhi (Beijing, China : 1980) Zhongguo Shiyou Daxue Xuebao (Ziran Kexue Ban)/Journal of China University of Petroleum (Edition of Natural Science) Tobacco Science and Technology Teikyo Medical Journal Connected Health

Latest Journals Agricultural Mechanization in Asia, Africa and Latin America International Medical Journal Technology Reports of Kansai University Asia Life Sciences Open Access Journals Tagliche Praxis Bulletin of National Institute of Health Sciences Journal of the Austrian Society of Agricultural Economics

Azerbaijan Medical Journal

Macrophage Phagocytic Activity and Capacity in Male White Rats Demonstrates the Immunomodulatory Activity of 70% Ethanol Extract of Arabic Jujube Leaves (Ziziphus Spina-Christi L.)
Journal ID : AMJ-15-11-2022-10790; Author : Novi Yantih, Sarah Zaidan, Elvira Andini, Desi Nadya Aulena, Kartiningsih,
Abstract : Arabic jujube leaves (Ziziphus spina-christi L.) contain various bioactive compounds and dichloromethane extract from the roots exhibits immunomodulatory activity. This study aims to determine the activity of a 70% ethanol extract of Arabic jujube leaves as an immunomodulator in male white rats based on macrophage phagocytic activity and capacity. Arabic jujube leaves were macerated for 24 hours. Rats were divided into 6 treatment groups. Each group consisted of 4 rats. Group I was administered water as a normal control, Group II was given Na-CMC as a negative control, and Group III was administered 2.7 mg/0.54 mL Phyllanthus niruri L. (P. niruri) product as a positive control, and Groups IV-VI were given 70% ethanol extract of Arabic jujube leaves at doses of 100, 200, and 400 mg/kg BW. On the 8th day, Groups II - VI were infected with Staphylococcus aureus. The average values of macrophage phagocytic activity in mice treated with the 70% ethanol extract of Arabic jujube leaves at doses of 100, 200, and 400 mg/kg BW were 65.25%, 73.50%, and 79.75%, respectively, whereas the macrophage phagocytic capacities were 448.5, 479.0, and 537.3, respectively. The higher the dose of extract, the higher the macrophage phagocytic activity and capacity, which indicates greater immunomodulatory activity. ANOVA showed that the macrophage phagocytic activity and capacity significantly differed among Groups I-VI. Data analysis using Duncan’s test showed that the phagocytic activity in Group III (positive control) was not significantly different from Group IV (treated with 400 mg/kg BW 70% ethanol extract of Arabic jujube leaves), whereas the phagocytic capacity of macrophages in the peritoneum of rats in the test groups significantly differed from the positive control group. Based on these results, it can be concluded that the 70% ethanol extract of Arabic jujube leaves has immunomodulatory activity in rats. The phagocytic activity of the 70% ethanol extract of Arabic jujube leaves at a dose of 400 mg/kg BW was not significantly different from that of the P. niruri product at a dose of 2.7 mg/0.54 mL, but its phagocytic capacity was slightly reduced.
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FACTOR CONTRIBUTING TO INCIDENCE OF PLANTAR FASCIOPATHY BY ASSESSING PLANTAR FASCIA THICKNESS ULTRASOUND MEASUREMENT
Journal ID : AMJ-15-11-2022-10789; Author : Yusak Mangara Tua Siahaan, Vinson hartoyo, Veli Sunggono,
Abstract : Plantar fasciopathy has become one of the most common underdiagnosed and undertreated heel pain. Many studies have been done to investigate predisposing factors for this disorder, but some of them contradicting. This may be attributed to the employment of physical examination as the sole diagnostic method, which is prone to bias. To investigate predisposing factor of plantar fasciopathy using ultrasound measurement. Cross-sectional study was conducted on patients with complaints of heel pain. They were assessed through physical examination and thickness of fascia plantar confirmed via ultrasound. Fascial thickness, demographic and risk factors data were all documented. A total of 106 patients with a mean age of 52.91±9.08 were employed. Bivariate analysis showed that age is the only significant risk factor (p=0.0017). ROC analysis indicated an AUROC value of 0.7097 (95% CI; 0.596-0.823). LR+ calculation 50 years old age cutoff showed a 62.5% higher risk value. Older age is associated with an increased risk of plantar fasciopathy and should be considered in patients with heel pain complaints. Ultrasound-measured fascia plantar is an objective, easy-to-do, more readily available, and cost-effective method to help diagnose plantar fasciopathy.
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Characteristic of Self-Harm Behaviour among Psychiatric Patients Visiting Outpatients Prof. HB Saanin Mental Hospital in Padang, Indonesia
Journal ID : AMJ-15-11-2022-10788; Author : Mutiara Anissa, Anita Darmayanti, Dessy Abdulla,
Abstract : Self-harm is a person's behavior who intentionally injures his body in various ways without any suicidal intent. Self-harm behavior can include slicing the skin with a razor or other sharp object, burning the body, hitting oneself, picking at scars, pulling hair, and consuming toxic substances. People with self-harm behavior are at high risk of committing suicide. Self-harm behavior is an attempt to escape from emotional pain. The purpose of the study was to determine characteristic of self-harm behaviour among psychiatric patients visiting outpatients Prof. HB Saanin Mental Hospital in Padang, Indonesia. The research used a descriptive study with a cross-sectional approach. The research instrument is Self-Harm Inventory (SHI), using a sample of 104 respondents with a consecutive sampling technique. The results showed that most respondents were in the age range of 36-45 years (35.6%), male (55.8%), single (49%) and homemakers (28.8%). More than half of patients had senior high school education (54.8%) and diagnosed with schizophrenia (67.3%). Most respondents are in the category of mild self-harm (78.8%), and the most self-harm behavior method is thoughts of attacking oneself. The study concludes that patients in the clinical population (with mental disorders) have self-harm behavior.
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Enzybiotics Activity of Phage Endolysin for Treatment of Multi-Drugs Resistant Escherichia coli UTI: in vitro and in vivo study
Journal ID : AMJ-14-11-2022-10785; Author : Haider N. Saqi,
Abstract : Resistant infection with multidrug-resistant Escherichia coli (E. coli) is one of the most common causative agents of bacterial infections and emergence as a multidrug resistant bacterium is a major public health threat worldwide and representing a real problem for health care providers. The use of Bacteriophage lytic enzymes (lysins) are highly evolved molecules that have been specifically developed by phages to quickly and efficiently allow their progeny to be released from the host bacterium while destructing that bacterium. This study aimed for isolation of endolysin from E. coli bacteriophages, and administering them systemic in vivo lab animal and measure the therapeutic efficacy, as well as evaluation of their biosafety for treatment of multi-drugs resistant Escherichia coli in urinary tract infection. This study was performed from September 2019 to February 2020, up to 30 bacteriological samples of uropathogenic Escherichia coli were collected, and examined with their anti-biogram, then bacteriophage cocktails were prepared for three resistant strains of them. Endolysins were extracted from their corresponding bacteriophages, they were characterized; the enzymatic and antibacterial activities of extracted endolysins were tested by in vitro assays; in addition, in vivo experiment was carried out on rabbit animals regarding the therapeutic effect of these extracted endolysins on UTI-causing E. coli. This study showed that the extracted endolysin from highly lytic coliphages were successful in reducing bacterial count in urine of treated rabbit animals which received specific endolysin via venous catheter. Endolysin can be extracted directly from their bacteriophages and being purified and used. The injection of rabbits with UTI with the proper dose of the extracted endolysin was effective in eradicating UTI in all of the treated animals.
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Literature Review: Telemedicine in Chronic Kidney Disease Patients
Journal ID : AMJ-14-11-2022-10783; Author : Nurhidayati, Merita Arini,
Abstract : Telemedicine is a necessity in health services for CKD patients amid technological advances so that health services can reach a wider community and remote places. There are several forms of telemedicine services in CKD patients with inhibiting factors, supporting factors and keys to success in their implementation. The purpose of this study is to determine the form of telemedicine services in CKD patients, find out the factors that are obstacles, supporters and keys to the success of a telemedicine service. Method with literature review discussing telemedicine services in CKD patients through SAGE Journal, Pubmed, BMJ Journal, Plos, JMIR with the keyword’s telemedicine, telehealth, e health on CKD patient. The results obtained by 36 journals selected based on exclusion criteria were finally taken 18 articles for review. Telemedicine services in CKD patients can be preventive, promotive, self-management, diagnostic and treatment services that are connected to an instrument between health workers and patients to achieve the desired health goals. The inhibiting factors, supporting factors and keys to the success of telemedicine services in CKD patients are centered on patients, health workers and technologists who will be bound to each other by an equal need in CKD patients.
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Comparison study of Circulating Adiponectin level in rheumatoid arthritis patients between Etanercept and Rituximab and their correlation with disease activity
Journal ID : AMJ-13-11-2022-10781; Author : Shatha Sabah Shyaa,
Abstract : Adiponectin considered the most abundant adipokine in the body, is a prime example. The development of RA causes the irreversible joint deformity, disability, and a decrease in quality of life. The study aimed to investigate the role of Adiponectin in rheumatoid arthritis patients under biological treatment (ETN, and RTX) and their correlation with Disease activity. During December 2021 and May 2022, case-control research was conducted. The current study included 100 RA patients from Iraq who had registered consultations with rheumatologists. The American-European Consensus Group classification criteria for RA diagnosis and patients were chosen to receive ETN and RTX by the most recent recommendations, and 50 healthy control group. ELISA was used to assess anti-CCP abs and serum adiponectin in RA patients and control groups. In the comparison, the level of Adiponectin in the serum of RA patients under DMARDs was significantly higher (p<0.001) than in the control group. The correlation between auto-antibody (anti-ccp) and adiponectin was a highly significant (r = 〖.533〗^(**)). There is a highly significant correlation between moderate and high CDAI, p-value <0.001. In addition to There are an association of adiponectin with biological treatment (OR = 1.003, p-value = .001, 95% CI = 1.002- 1.005). The sensitivity and specificity of adiponectin were (1.0, 0.80) respectively by ROC curve with cut of point (400,603) pg/gm. The current study concluded high levels of circulating Adiponectin in RA patients have been linked to increased disease activity and disability. Despite continuing to receive Etanercept and Rituximab treatment, there was a positive correlation between the serum levels of adiponectin and the specific diagnostic autoantibody Anti-CCP abs level in patients with rheumatoid arthritis. As a result, it has been hypothesized that this adipokine may have pro-inflammatory effects in rheumatoid arthritis.
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A Simple demonstration to comprehend the application of Laplace law in human physiology
Journal ID : AMJ-13-11-2022-10780; Author : Kamalakannan Vadivel, Prashanth Talikoti, Lord Krishna Govindaraju, Nilesh N Kate,
Abstract : The Laplace law relates the wall tension with the radius of curvature and the pressure in hallow structures. It is expressed as tension T is directly proportional to the product of the radius of the curvature r, and the pressure p, in the hallow structure. The expression is quite straight forward and easy to understand. The difficulty arises when the law is applied to understand the physiological process, as many a times students tend to understand that tension and pressure changes unidirectionally, and therefore tend to believe that the estimate which they directly feel by palpating the hallow structure is pressure rather than tension. To make them understand the difference, a simple demonstration was done using a balloon and a needle to make the concept clear. The model presented here is less expensive and is of use in resource limited settings. The demonstration of the Laplace’s law using this techniques was found to be helpful in intuitive understanding of this basic biophysical principle in comprehending physiological principles based on Laplace’s law.
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Significant reduction of serum coenzyme Q10 in pediatric nephrotic patient with steroid resistance in comparison with steroid sensitive and control groups
Journal ID : AMJ-13-11-2022-10779; Author : Rasha K.J. Ali, Omar F. Abdul-Rasheed, Mohammed Abed Darweesh,
Abstract : Steroid-resistant nephrotic syndrome is a causative agent of end-stage kidney disease in children and young people. A genetic factor is responsible for around 30% of children with steroid resistance. In the first decades of the new century, research has revealed a role for CoQ in the regulation of gene expression, mitochondrial activity, and cell signaling. Primary CoQ10 insufficiency may be susceptible to treatment with CoQ10 supplements by omitting the biosynthetic deficiencies. The objective of present research: Analyze the association between steroid response coenzyme Q10 serum levels. HPLC evaluate serum coenzyme Q10 in total 80 patients with NS (40 SRNS and 40 SSNS) and 80 health control of Iraqi origin. Highly significant difference in COQ serum level between control and nephrotic groups (p˂0.001). This is the first research project of its kind in Iraqi origin to look the relation between serum COQ10 level and pediatric steroid resistance nephrotic syndrome .serum Q10 as diagnostic biomarker in patient with ADCK4 associated SRNS.
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Analysis Of Sleep Disorder In Acute Lymphoblastic Leukemia
Journal ID : AMJ-13-11-2022-10777; Author : Minda Hadiyanti Lubis, Olga Rasiyanti Siregar, Rizky Adriansyah,
Abstract : Acute lymphoblastic leukemia (ALL) is the most common cancer in children and adolescents. Chemotherapy for leukemia has many side effects, toxicity, and length of stay that will affect the patient's quality of life. One of the factors that contribute to children's quality of life, including in the case of leukemia, is sleep disorder. The aim of this study is to analyze the risk factors that cause sleep disorder in ALL. This study is an analytic study with a cross-sectional design conducted in children with a diagnosis of acute lymphoblastic leukemia at Haji Adam Malik General Hospital Medan who met the inclusion and exclusion criteria from October 2021 to April 2022. Subject's parents were interviewed based on the questions on the CSHQ questionnaire. Out of 50 children with acute lymphoblastic leukemia, 33.3% of male and 45% of female in this study had sleep disorders. Based on nutritional status, 63.2% of children with normal nutritional status and 22.6% of malnourished children experienced sleep disorders. Based on the type of medication, 50% of children given prednisone therapy experienced sleep disorders. Prednisone is the most chemotherapy treatment agent and it has sleep disorder effect in ALL patients, there is a significant partial association between nutritional status and sleep disorders in children with ALL, there is a significant association between the type of medication and sleep disorders in children with ALL.
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Fennel Seeds (Foeniculum Vulgare M.) and Khellah Seeds (Ammi Visnaga L.) Downregulate KIM-1 and NFAT-5 Genes Expression in LPS-Induced Nephrosis
Journal ID : AMJ-12-11-2022-10775; Author : Amira Abd El-Rhman, Huda E. Megahd,
Abstract : Acute kidney injury (AKI) is a significant biomedical issue stimulated by many signaling pathways by lipopolysaccharide (LPS). This study looked at how fennel and khellah seed extracts (FSE&KSE) ameliorate the nephrosis that LPS-induced in experimental rats. Forty healthy adult male Westar albino rats weighing 200±20g, were used. Ten rats were left as control group G1, while other 30 rats were received a single intraperitoneal injection by LPS (12mg/kg b. wt.) and then divided into 3 groups 10 rats for each. G2 represented the positive control, however the remaining two groups treated orally by FSE and KSE for 4 weeks. The injection of LPS increased KIM-1 and NFAT-5 genes expression, inflammatory biomarkers, nephrotic proteinuria moreover histological and structural changes in kidney tissue, while administration of FSE and KSE resulted in a significant (P˂0.05) improvement in biochemical parameters and ameliorate structural changes in kidney tissue and down regulate of KIM-1and NFAT-5 genes expression related to protect kidney from LPS injury.
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