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05 Oct 2022
30 Sep 2022
Azerbaijan medical journal (ISSN: 0005-2523) - is a scopus indexed journal since 1961. The publisher of the journal is Izdatel'stvo Elm by WHO Office in Azerbaijan. Azerbaijan medical journal (AMJ) is also UGC approved. The journal publishes general medicine, health science, psychological, pharmaceutical journals and so on.
Aim and Scope
Azerbaijan Medical Journal
Azerbaijan Medical Journal (ISSN: 0005-2523) - is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to.
Azerbaijan Medical Journal
Diabetic nephropathy (DN) is an important cause of end-stage renal disease and is recognized as a public health problem worldwide. However, there have been no nationwide surveys of DN prevalence in China. This study is aimed at estimating the pooled prevalence of DN among patients with type 2 diabetes in China. Published studies on the prevalence of DN among patients with type 2 diabetes published from January 1980 to October 2019 were systematically reviewed using PubMed, Embase, Google Scholar, Chinese Wanfang databases, and Chinese National Knowledge Infrastructure. The pooled prevalence of DN was estimated with the random effects model using R software. Prevalence estimates were also stratified by study design, methodological approach, and study population characteristics. Thirty studies with a total of 79,364 participants were included in our study. The overall pooled prevalence of DN was 21.8% [95% confidence interval (CI): 18.5-25.4%]. Subgroup analysis found that the prevalence of DN varied significantly according to different DM and DN diagnostic criteria (P < 0:05); the pooling estimate was the highest in the west region of 41.3%, followed by that in the east region of China with 22.3%, northeast region with 20.7%, and central region with 15.6% (P < 0:05), and was higher in the maledominated studies 27.7%, compared with the female-dominated studies 17.6% (P < 0:05). The prevalence of DN is high in Chinese patients with type 2 diabetes and shows geographic and gender variation. These data indicate that national strategies aimed at primary and secondary prevention of DN and screening programs for DN are urgently needed to reduce the risk and burden of DN in China
PHYTO- AND PELOID PRODUCTS IN A COMPLEX SPA THERAPY OF PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
Non-alcoholic fatty liver disease has emerged a major challenge because of it prevalence, difficulties in diagnosis, complex pathogenesis, and lack of approved therapies. As the burden of hepatitis C abates over the next decade, non-alcoholic fatty liver disease will become the major form of chronic liver disease in adults and children and could become the leading indication for liver transplantation. This overview briefly summarizes the most recent data on the pathophysiology, diagnosis, and treatment of non-alcoholic fatty liver disease. Ongoing clinical trials are focused on an array of disease mechanisms and reviewed here are how these treatments fit into the current paradigm of substrate overload lipotoxic liver injury. Many of the approaches are directed at downstream events such as inflammation, injury and fibrogenesis. Addressing more proximal processes such as dysfunctional satiety mechanisms and inappropriately parsimonious energy dissipation are potential therapeutic opportunities that if successfully understood and exploited would not only address fatty liver disease but also the other components of the metabolic syndrome such as obesity, diabetes and dyslipidemia.
PARAMETERS OF THE SECOND GENU OF THE FACIAL NERVE IN PEOPLE OF MESO- AND BRACHIOCEPHALIC TYPE OF THE CEREBRAL SKULL
Otitis media, mastoiditis or the pressure effect of tumorous lesions such as cholesteatoma can be the cause of facial canal dehiscence and facial nerve paralysis. The most common segment involved in dehiscence is the tympanic segment and the second most common is the lateral aspect of the facial canal in the oval window area. To determine the prevalence of the facial canal dehiscence and the relationship between the angle at the second genu of the facial nerve and facial canal dehiscence. We evaluated the surgical findings in 113 patients who underwent surgery for cholesteatoma. Facial canal dehiscence was detected in 62 of the 113 patients. Patients were divided into two groups: Group 1, with dehiscence of the facial canal and Group 2, without dehiscence of the facial canal. The mean angles at the second genu of the facial nerve in Groups 1 and 2 were 117.8◦ ± 9.63◦ and 114◦ ± 9.9◦, respectively. There was a statistically significant difference between the mean angles at the second genu for the two groups (p = 0.04).In patients with dehiscence of the facial canal, the angle at the second genu was found to be wider than those without dehiscence
EVALUATION OF FERRITIN LEVELS DURING IRON OVERLOAD IN CHILDREN WITH TRANSFUSION-DEPENDENT -THALASSEMIA
Hodgkin lymphoma is a malignant proliferation of lymphatic system which when advanced can involve the bone marrow. It is usually indolent and responds to chemotherapy. However the prediction of rapidly progressive disease is often dependent on lot of clinicopathological parameters. Serum ferritin may act as a marker for disease activity in these patients. But the prior studies have failed to establish its role or group the patients into prognostic categories. To study the status of serum ferritin at time of admission and after completion of chemotherapy and also iron overload induced organ involvement in the form of hepatic, cardiovascular and thyroid dysfunction in nine patients admitted in our ward with Hodgkin lymphoma and receiving treatment in the form of chemotherapy. A spectrum of clinicopathological variables were tested at baseline and after treatment liver function test, thyroid function test, 2D echocardiography, Ultrasound abdomen, PET scan and serum ferritin level. Serum ferritin at baseline statistically correlated with disease activity however the final ferritin values reduced to significant values in patient that underwent remission, and hence grouping of patients based on serum ferritin values can serve as better outcome predictors. Although transfusion requirement was very rare in the patients the levels of serum ferritin correlated with disease activity. Serum ferritin level may act as a predictor of disease activity and remission.
As you know, cardiovascular diseases are a common cause of death and disability, among them a special place is occupied by stroke. To determine the quantitative parameters of blood flow of the main brain vessels in patients with left hemispheric ischemic stroke (HIS). Transcranial dopplerography (TD) of the middle cerebral artery (MCA) and middle cerebral vein (MCV), the Rosenthal’s vein, the Galena’s vein and Straight sinus (SS) was performed in 89 patients with HIS. The comparative group (CG) was organized from 52 patients without cardiovascular diseases. The maximum systolic velocity (Vs), the end diastolic velocity (Vd), the resistance index (RI) in MCA, and the Vs of the main brain veins were determined. Sistolic blood flow velocity in the mid-cerebral artery in 85.4% of patients was below 70 cm/s and averaged, 54.9 ± 7.1 cm/s. In 9.2% of cases, the size of the affected area in the left hemisphere did not exceed 1 cm according to the results of tomography, and in 90.8% of cases it ranged from 1 cm to 2 cm According to the results of TD, MSA stenosis was detected in 78 (87.6%) cases, which was confirmed by MRI angiography. Among the patient with the Hemispheric ischemic stroke the Rosenthal’s vena was visualized in 81 (91,0%) cases, the Galen’s vena – in 83 (93,3%) cases, the median cerebral vein (MCV) - in 75 (84,3%) and the Straight sinus - in 79 (88,9%) cases, respectively. In a patients of the comparative group, visualization of this veins was successful in 42 (80.8%), 47 (90.4%), 31 (59.6%) and 32 (61.5%) cases, respectively. In a patients with HIS, all the main cerebral veins were visualized significantly (P <0.05 and P <0.001) more often than in the CG (with the exception of the Galen vein). In a patient with HIS Vs in the deep median cerebral vein was 25.3+3.6 cm/s; in the basal vein of the brain -24.9+2.6 cm/s; in the large vein of the brain -26.3+2.1 cm/s; in the direct sinus, 32.1 ± 2.6 cm/s, respectively. Stenosis of the middle cerebral artery, a decrease in systolic blood flow velocity less than 70 cm/s, an increase in resistance index more than 0.70 and in the pulsation index more than 1.35 is a frequent finding in ischemic stroke. The correspondence between the severity of the stroke and the value of the systolic blood flow velocity in the cerebral veins was revealed. Good visualization of the main cerebral veins is due to the increase in blood flow velocity in them
Astrocytes comprise the major non-neuronal cell population in the mammalian neurovascular unit. Traditionally, astrocytes are known to play broad roles in central nervous system (CNS) homeostasis, including the management of extracellular ion balance and pH, regulation of neurotransmission, and control of cerebral blood flow and metabolism. After CNS injury, cell–cell signaling between neuronal, glial, and vascular cells contribute to repair and recovery in the neurovascular unit. In this mini-review, we propose the idea that astrocytes play a central role in organizing these signals. During CNS recovery, reactive astrocytes communicate with almost all CNS cells and peripheral progenitors, resulting in the promotion of neurogenesis and angiogenesis, regulation of inflammatory response, and modulation of stem/progenitor response. Reciprocally, changes in neurons and vascular components of the remodeling brain should also influence astrocyte signaling. Therefore, understanding the complex and interdependent signaling pathways of reactive astrocytes after CNS injury may reveal fundamental mechanisms and targets for re-integrating the neurovascular unit and augmenting brain recovery.
PROCESSING LOCALIZATION and QUESTIONNARE EORTC QLQ-C30 RESULTS in PATIENTS with BREAST CANCER and METASTASIS
Health utilities summarize a patient’s overall health status. This study estimated utilities based on the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (QLQ-C30), a widely used measure of health-related quality-of-life (HRQoL) in oncology, using published mapping algorithms. Data were from the Anaplastic Lymphoma Kinase (ALK) in Lung Cancer Trial of brigatinib (ALTA; NCT02094573), an open-label, international, phase 2 study. ALTA evaluated the efficacy and safety of two randomized dosing regimens of brigatinib in patients with locally advanced or metastatic ALKþ non-small cell lung cancer (NSCLC) that had progressed on prior therapy with crizotinib. QLQ-C30 scores were mapped to European Quality-of-Life-5 Dimensions (EQ-5D) utility scores using two published algorithms (Khan et al. for EQ-5D-5L; Longworth et al. for EQ-5D-3L). The impact of brigatinib treatment on health utilities over time was assessed. The analysis included 208 subjects. Mean baseline utility scores for both algorithms ranged between 0.60 0.71 and increased to 0.78 by cycle 5. Utility improvements were sustained during most of the treatment, before disease progression. Minor variations were observed between utility scores; Khan et al. estimates were approximately 0.01 or 0.02 points lower than Longworth et al. estimates. Algorithms considered were limited to those available in the published literature at the time of the study. This utility analysis was exploratory, and the ALTA trial did not include an internal control group (i.e. standard of care) and was not powered to detect differences in QoL/utility outcomes between treatment arms. Converting QLQ-C30 scores into utilities in trials using established mapping algorithms can improve evaluation of medicines from the patient perspective. Both algorithms suggested that brigatinib improved health utility in crizotinib-refractory ALK þ NSCLC patients, and improvements were maintained during most of the treatment.
MANAGEMENT ASPECTS OF CHILDREN'S HEALTH: DYSPLASTIC-DEPENDENT PATHOLOGY OF THE BRONCHOPULMONARY SYSTEM AND ECOLOGICAL HETEROGENEITY OF THE ENVIRONMENT
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of primarily premature infants that results from an imbalance between lung injury and repair in the developing lung. BPD is the most common respiratory morbidity in preterm infants, which affects nearly 10, 000 neonates each year in the United States. Over the last two decades, the incidence of BPD has largely been unchanged; however, the pathophysiology has changed with the substantial improvement in the respiratory management of extremely low birth weight (ELBW) infants. Here we have attempted to comprehensively review and summarize the current literature on the pathogenesis and pathophysiology of BPD. Our goal is to provide insight to help further progress in preventing and managing severe BPD in the ELBW infants.
The organization of the Enteric Nervous System (ENS) was studied in the human colon. Fragments of the whole colonic wall were either routinely processed or Zinc-Iodide Osmium impregnated. Single-layer preparations were also obtained from some of the Zinc-Iodide Osmium-impregnated specimens. The results showed some differences in the organization of human colonic ENS from that of other mammals. In fact, the human submucous plexus was made up of three interconnected ganglionated networks arranged along three different planes. With respect to the myenteric plexus, its ganglia were large sized and irregularly shaped. Moreover, during the microdissection of the colonic wall, we found the absence of a cleavage plane between the circular and longitudinal muscle layers; on the other hand the cleavage plane between mucosa and submucosa was not immediately below the muscularis mucosae, but slightly deeper, since the innermost part of the submucosa remained adhering to overlying layers.
This article highlights the issues of studying the psychosocial rehabilitation of patients with posttraumatic stress disorder, provides findings of evidence-based medicine point of view on the need and appropriateness of the use of rehabilitation measures and the provision of psychosocial assistance to this category of patients. The study involved 38 patients of the main group with post-traumatic stress disorder (F43.1) in accordance with ICD-10 and 19 patients from the control group with a similar diagnosis, but without participation in psychosocial rehabilitation activities. Based on a detailed study and statistical analysis of patients' complaints, a general "bank" of the identified problems of psychosocial functioning in various spheres of activity was formed, the most important directions in the rehabilitation process were detected. Comparison of the main and control group results testifies in favor of the effectiveness of the developed complex system for the rehabilitation of patients with post-traumatic stress disorder (PTSD), as evidenced by the significant predominance of the recovery rate and the absence of patients with mental deterioration in the main group. The results of the study carried out according to clinical and psych diagnostic indicators show the effectiveness of the developed complex system for the rehabilitation of patients with PTSD. The research work proves that the goal of rehabilitation work in patients with PTSD is achievable only when the activity of the pathological process, the mental state of the patient, his personality, features of the immediate social environment and individual standard of living are sufficiently taken into account.