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Azerbaijan Medical Journal

(ISSN: 0005-2523)

Azerbaijan medical journal (ISSN: 0005-2523) - is a scopus indexed journal since 1961. The publisher of the journal is Izdatel'stvo Elm by WHO Office in Azerbaijan. Azerbaijan medical journal (AMJ) is also UGC approved. The journal publishes general medicine, health science, psychological, pharmaceutical journals and so on.

Aim and Scope

Azerbaijan Medical Journal

Azerbaijan Medical Journal (ISSN: 0005-2523) - is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to.

Anatomy Physiology Biochemistry Pharmacology Pathology Forensic medicine Microbiology Community Medicine Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases Anaesthesia Cancer research Neurosurgery Orthopedics Gastroenterology Neurology Nephrology Medical education Orthopaedics Paediatrics Reproduction Cardiology Diabetes Surgery Nursing Otolaryngology Dental Psychology Anesthesiology Dermatology Endocrinology Hepatology Urology Venereology Psychiatry Biotechnology Pharmacy ENT Pharmaceutical Chemistry Pharmaceutical Analysis Pharmaceutics Pulmonology Pharmacognosy Pharmaceutical Phatmaceutical Technology Biopharmaceutics Pharmacokinetics Pharmacodynamics Industrial Pharmacy Drug Design Quality Assurance Drug Regulatory Affairs Phytochemistry Drug Delivery Systems Pharmaceutical Nanotechnology Pharmaceutical Microbiology Hospital Pharmacy Clinical Pharmacy Pharmacy Practice Drug Discovery Drug Metabolism Toxicology Clinical Research Pharmacogenomics Phrmacoinformatics Pharmacovigilance< Life Sciences like Chemistry Biomedical Sciences Microbiology Immunology Forensic Epidemiology Oncology Biomedicine Dentistry Physiotherapy Gynaecology Dermatoepidemiology Neuroscience Ophthalmology Sexology Osteology Kinesiology Angiology/Vascular Medicine Critical care Medicine Haematology Infectious Diseases and Vaccinology Bariatrics Pharmacy and Nursing Pharmacognosy and Phytochemistry Radiobiology Clinical immunology Clinical and Hospital Pharmacy Cell Biology Genomics and Proteomics Healthcare Services Healthcare Management Bioinformatics and Biotechnology Geriatric Medicine

Latest Journals

Azerbaijan Medical Journal

The Pharmacologic Role of Antioxidant Property of Beta carotene in Reducing Amikacin-Induced Nephrotoxicity
Journal ID : AMJ-16-06-2022-10250; Author : Muthanna T. Khalaf, Zeina A. Althanoon,
Abstract : Nephrotoxicity is a great healthcare challenge in clinical care settings. Kidneys are subject to meteors from different chemicals, drugs, and xenobiotics; which make them susceptible to injury, among these are aminoglycoside antibiotics. A wide variety of therapeutic remedies has been used to protect kidneys against the toxicity of various drugs and chemicals including, vitamins, minerals, and herbal products. Beta carotene can decrease oxidative stress, so it can protect the kidney from the toxicity and damage induced by oxidative stress. In this study, we tried to investigate the possible ameliorative effect of beta carotene against amikacin-induced nephrotoxicity when given before and during the treatment of amikacin. Twenty-eight male albino rats were divided into five groups (seven in each group): 1-Control group (A): was intended for distilled water during the study period. 2-Amikacin group (B): were injected intraperitoneally with amikacin (150mg/kg/day) for two weeks. 3-Beta carotene group (C): were gavaged with beta carotene orally (100mg/kg/day) for 9 days. 4-Beta -carotene and amikacin group (D): were gavaged with beta carotene orally (100mg/kg/day) for 9 days alone, then injected intraperitoneally with amikacin (150mg/kg/day) and gavaged with beta carotene orally (100mg/kg/day) for two weeks. At the end of the study, animals were fasted and sacrificed, and serum was used for biochemical analysis and kidneys for histopathology. The results showed an elevation in serum MDA significantly (P < 0.005) and a reduction in T-AOC and GSH significantly (P < 0.005) in the amikacin group compared to the control group, whereas groups administered beta carotene with AMK showed significant improvement in the oxidative parameters compared to the AMK-treated group. In conclusion, beta carotene can act as a good antioxidant, preventing the expected nephrotoxicity induced by AMK.
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Device associated nosocomial infection in NICU: a prospective observational study.
Journal ID : AMJ-16-06-2022-10249; Author : Subhashree Karˡ,(1) Department of Pediatrics, SVPPGIP and SCBMCH, Cuttack., Swarupa Panda1,(1) Department of Pediatrics, SVPPGIP and SCBMCH, Cuttack., Prasant Kumar Bal2,(2) Department of Plastic surgery,SCBMCH,Cuttack., Mrigendra Nath Tudu3,(3). Department of Pediatrics, Fortis hospital, Bengaluru., Bharati Sahoo1.,(1) Department of Pediatrics, SVPPGIP and SCBMCH, Cuttack.,
Abstract : Nosocomial infections(NIs) are the most important current challenge faced by neonatal intensive care units (NICUs). Although systematic surveillance is an integral part of all approaches to decreasing NIs, the current methods for recording healthcare-associated infections in our country are grossly inadequate. To determine the prevalence and risk factors for device-associated infections in a tertiary care center in eastern India. This prospective observational study was undertaken in the NICU, Department of Pediatrics, SCB Medical College, Cuttack, and SVPPGIP, Cuttack. Neonates who stayed in the NICU for more than 48 hours and needed one or more devices (e.g. ventilator or CVL) are included in this study. They were observed for nosocomial infections. In this study, we included 630 neonates. A total of 94 neonates were found to have a nosocomial infection. The patient, days were 2516 days. During the period of study, central line days were found to be 173 days and ventilator days, 710. The prevalence of nosocomial infection was found to be 14.9%. Male babies were more likely to have nosocomial sepsis. Staphylococcus aureus was found to be the major organism. Nosocomial infection in NICU graduates who are put on several devices is an important preventable problem. The present study reveals that sepsis (LOS) and pneumonia are major device-associated infections. Staphylococcus aureus is most commonly associated with E. coli and Klebsiella. Their prevention can be achieved by applying strict protocols for sepsis.
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Impact of vitamin D3 supplement on some biochemical markers in patients with dental implant
Journal ID : AMJ-15-06-2022-10247; Author : Omer W. Salih, Faehaa A. Al-Mashhadane, Rayan S. Hamed,
Abstract : To investigate the effects of systemic supplementation with vitamin D3 on serum Vitamin D3, alkaline phosphatase, serum CRP and serum calcium in patients treated with dental implants. Twelve patients were classified into two groups: control group: receiving dental implants in posterior maxillary extraction sites whom did not receive any medication, and treatment group: receiving dental implants in posterior maxillary extraction sites with 1000 I/U per day oral tablet of vitamin D3 supplement for 3 months. Blood samples were collected on the 1st day of study (after the insertion of dental implant), 1 week after, and once again three months later for biochemical analysis of serum alkaline phosphatase, C-reactive protein(CPR), calcium and vitamin D3. Differences were observed between control and treatment groups throughout the 3 months of the study yet was not significant. Vitamin D supplementation has a non-significant effect on serum alkaline phosphatase, serum CRP and serum calcium in patients treated with dental implants.
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Investigation of Topical Nifedipine on Total Antioxidant Capacity and Mitochondrial Function During Facial Skin Wound Healing in Rabbits
Journal ID : AMJ-14-06-2022-10246; Author : Wasan J. Al-Dabbagh, Faehaa A. Al-Mashhadane, Ayad A. Al-Sarraj,
Abstract : The objective of this study was to evaluate the impacts of 1% and 2% topical nifedipine ointments on total antioxidant capacity and mitochondrial function during the facial skin wound healing in rabbits. Nifedipine ointments 1% and 2% were prepared. Fifty healthy male rabbits were involved and distributed into two equal group 25 of each according to study period: group A (7 days) and group B (14 days). Each group was subdivided into five groups (5 rabbits/group): group I (Normal): rabbits were not subjected to any surgical procedure or treatments; group II (negative control): rabbits had surgical wound without treatment; group III (positive control): rabbits had surgical wound, treated with white petroleum; group IV(nifedipine 1%): rabbits had surgical wound, treated with nifedipine 1% ointment; and group V(nifedipine 2%): rabbits had surgical wound, treated with nifedipine 2% ointment. Blood samples were collected from all animals after euthanasia for analysis of biochemical parameters. The results revealed a significant increase of total antioxidant capacity levels in the nifedipine 1% group on the 7th and 14th days of study in comparison to the other groups. There is no substantial variance in lactate and pyruvate levels between the normal and nifedipine 1% groups, but there is a substantial variance when compared to the other groups. Topical nifedipine 1% ointment had a beneficial effect on the wound healing process. It had superior effect on total antioxidant capacity and promoted mitochondrial function during the healing process, whereas nifedipine 2% ointment had no such effect.
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Evaluation of functional outcomes of turn down Achilles tendoplasty with bone anchoring polypropylene suture using 18G hypodermic/spinal needle for the repair of Achilles tendon injuries.
Journal ID : AMJ-14-06-2022-10245; Author : Syama Sundar Behera,Department of Burns, Plastic and Reconstructive Surgery, SCB Medical College & Hospital, Cuttack., Subrat Kumar Samantara,Department of Surgical Oncology,A.H Postgrauate Institute of Cancer, Cuttack., Subhashree Kar,Department of Pediatrics, SVPPGIP and SCBMCH, Cuttack., Prasanta Kumar Bal,Department of Burns, Plastic and Reconstructive Surgery, SCB Medical College & Hospital, Cuttack., Bibhuti Bhusan Nayak,Department of Burns, Plastic and Reconstructive Surgery, SCB Medical College & Hospital, Cuttack., Pruthwiraj Singh,Department of Burns, Plastic and Reconstructive Surgery, SCB Medical College & Hospital, Cuttack.,
Abstract : Achilles tendon rupture (ATR) presents a unique challenge to the surgeon because the gap in the Achilles tendon must be bridged by a procedure other than primary repair. Although there are numerous approaches to addressing this issue, the gastro-soleus fascial turndown flap with bone-anchoring suture or osseointegration stands out. Despite its popularity, there are few studies that have objectively evaluated the procedure's efficacy. To evaluate the efficacy of turndown flap repair with bone anchoring polypropylene suture through an 18G hypodermic/spinal needle with special reference to its various functional outcomes. This prospective observational study was conducted in the Department of Burns, Plastic, and Reconstructive Surgery, SCB Medical College & Hospital, Cuttack, for a period of two years from November 2018 to December 2020. Tendo Achilles injury patients admitted to the department due to various etiologies were considered as study samples. The difference between pre-operative and post-operative (Achilles Tendon Total Rupture Score) ATRSs was calculated. The difference between post-operative and pre-operative calf circumferences was calculated. A total of 35 patients underwent surgery for ATR. Male patients predominated. The most common cause was accidental injury in an Indian closet. The majority of patients (13, or 37.14%) presented with a gap of 4 to 5 cm between the proximal and distal segments with the ankle in a neutral position. Out of the study population, 11 patients (31%) had an ATR score difference ranging from 31–40. Thirtten patients (37.14%) had a difference ranging from 1.1 to 2 cm. Sixty percent of the cases had a good outcome. Two patients had an unsatisfactory outcome, which constituted around 5.72% of the study population. The turndown flap with bone-anchoring polypropylene suture using an 18G hypodermic/spinal needle is an effective, relatively simple, and non-time-consuming procedure with a very short learning curve and very minimal morbidity for the repair of Achilles tendon injuries with a gap (where primary repair is not possible).
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Clinical and anti-inflammatory effects of fresh and Commercial Aloe Vera Gel on IL-6 levels in Oral Mucosal Burns induced in Rabbits
Journal ID : AMJ-13-06-2022-10244; Author : Hajer Y. Mohammed, Ghada A. Taqa, Karam H. Al-Mallah,
Abstract : Aloe Vera is a vitamin and mineral-rich plant with numerous health and skin-care applications. The study's goal is to determine how Aloe Vera affects IL-6 levels in an adult male New Zealand rabbit. In this experiment, 48 male New Zealand rabbits were used. In each rabbit, ketamine and xylazine were administered intramuscularly into the thigh muscle. In less than 5 minutes, an appropriate level of anesthesia was established. In the operating room, animals were placed on the operating table. For unipolar cauterization, electrosurgical generator cautery was used throughout the procedure. We burned 0.5 cm of the rabbits' buccal oral mucosa with a unipolar electrocautery pen with a (2.5) inch standard blade electrode at 95.5 C°. After that, the rabbits were placed into four groups, each with 12 rabbits: Group 1 (normal oral mucosa without burning), Group 2 (burning oral mucosa without medicine), Group 3 (Aloe Vera plant/fresh gel), and Group 4 (Aloe Vera /commercial gel). Each group's animals were euthanized on days three (3), seven (7), and fourteen (14) of the trial, resulting in a total of 12 rabbits slaughtered during each medication period. The level of IL6 in serum was determined using blood and buccal tissue samples. The untreated burn site had the greatest amount of IL-6 throughout the experiment, while the burn site treated with Aloe Vera gel had the lowest level of IL-6. Fresh Aloe Vera gel and commercial Aloe Vera gel are thought to have a significant anti-inflammatory impact by lowering the amount of inflammatory mediator (IL-6) and so promoting wound healing.
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Effects of diethylene glycol with or without vitamin C on liver and kidney functions in rabbits
Journal ID : AMJ-12-06-2022-10242; Author : Nenuphar Naktal Ibrahimm ALtaaye, Faehaa Azher Al-Mashhadane, Saba k Aldeen Ibrahim ALtaaye,
Abstract : The aim of the present interventional study was to determines the effects of diethyleneglycol (DEG) with or without vitamin C on liver and kidney in rabbits and to study the defending properties of vitamin C against DEG induced changes. Liver and kidney function tests were carried out for 18 rabbits who had divided into 3 groups as follow: T-Group: rabbits were given (DEG) (40 mg/kg body weight/day) for 14 days and were sacrificed on the 14th day. TC-Group: rabbits were given DEG (40 mg/kg body weight/day) with vitamin C (10mg/kg/day) for 14 days and sacrificed on the 14th day. C-Group: rabbits were maintained on standard diet and water only. Venous blood samples (5ml) were withdrawn from experimental rabbits via jugular vein during animal sacrificing and left until set to clot, centrifuged, and serum collected and kept at -20 ˚C until analysis of the Liver and kidney functions including Alkaline Phosphatase, GOT, GPT, Creatinine, Urea, using special kits. Significant increase in serum levels of alkaline phosphatase (ALP), aminotransferase GOT, GPT, and urea and creatinine in the treatment groups compared to the other groups. DEG (40 mg/kg/day) for 14 days can result marked changes in serum biochemical markers of liver and kidney in rabbits.
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DETERMINATION OF NEURODEGENERATIVE MARKERS IN THE BLOOD SERUM OF PATIENTS WITH AUTOIMMUNE THYROIDITIS
Journal ID : AMJ-12-06-2022-10241; Author : Rahimova, R.R,
Abstract :

Vitamin D is a steroid hormone regulating calcium-phosphorus homeostasis, immune response and brain function. In the past thirty years, an increasing number of cohort studies, metaanalyses and randomized controlled trials (RTCs) evaluated the serum levels of 25-hydroxyvitamin D [25(OH)D], which is considered the Vitamin D status biomarker, in patients affected by neurological, psychiatric and autoimmune diseases. Although an association between low 25(OH)D serum levels and the prevalence of these diseases has been found, it is still unclear whether the serum 25(OH)D measurement can be clinically useful as a biomarker for diagnosis, prognosis and predicting treatment response in neurodegeneration, mental illness and immune-mediated disorders. The lack of standardized data, as well as discrepancies among the studies (in the analytical methods, cut-offs, endpoints and study sets), weakened the findings achieved, hindered pooling data, and, consequently, hampered drawing conclusions. This narrative review summarizes the main findings from the studies performed on serum 25(OH)D in neurological, psychiatric and autoimmune diseases, and clarifies whether or not serum 25(OH)D can be used as a reliable biomarker in these diseases.

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PELVIOMETRIC PARAMETERS OF FEMALE PELVIS DEPENDING ON AGE
Journal ID : AMJ-12-06-2022-10240; Author : Khidirov, E.A., Ganbayeva, Sh.F., Isayev, N.N.,
Abstract :

Pelviometric studies of 36 female pelves of a narrow configuration (18 pelves with a uniformly constricted shape and 18 - with a transversely narrowed) were conducted. The change in the dimensional characteristics of these pelves was studied depending on age (age range 16-60 years). It was found that both groups of constricted pelvic forms were not characterized by high variability in the age aspect and their sizes were relatively stable throughout life. At the same time, it was found that the parameters of the transversely shaped forms of the pelves were more susceptible to changes than the dimensions of the uniformly constricted configurations

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PHYTO- AND PELOID PRODUCTS IN A COMPLEX SPA THERAPY OF PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
Journal ID : AMJ-12-06-2022-10238; Author : Efimenko, N.V., Kоlomeytsev, V.V., Simonova, T.M., Shvedunova, L.N., Botvineva, L.А,
Abstract :

Non-alcoholic fatty liver disease has emerged a major challenge because of it prevalence, difficulties in diagnosis, complex pathogenesis, and lack of approved therapies. As the burden of hepatitis C abates over the next decade, non-alcoholic fatty liver disease will become the major form of chronic liver disease in adults and children and could become the leading indication for liver transplantation. This overview briefly summarizes the most recent data on the pathophysiology, diagnosis, and treatment of non-alcoholic fatty liver disease. Ongoing clinical trials are focused on an array of disease mechanisms and reviewed here are how these treatments fit into the current paradigm of substrate overload lipotoxic liver injury. Many of the approaches are directed at downstream events such as inflammation, injury and fibrogenesis. Addressing more proximal processes such as dysfunctional satiety mechanisms and inappropriately parsimonious energy dissipation are potential therapeutic opportunities that if successfully understood and exploited would not only address fatty liver disease but also the other components of the metabolic syndrome such as obesity, diabetes and dyslipidemia.

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