Abstract : Eclampsia and Pre-eclampsia account for about half of these cases Worldwide and have been recognized and described for year despite the general lack of understanding of the disease. Hypertension is the most common medical problem encountered during pregnancy. Pre-eclampsia (PE) is a metabolic disorder that adversely affects the lives of mother and their infants. Even though, several studies have been conducted on PE, no effective diagnostic and therapeutic agents were developed so far. Eclampsia, which is considered a complication of sever pre-eclampsia. It is commonly defined as new onset of Grand mal seizure activity or/and unexplained coma during pregnancy or postpartum in a female with signs or symptoms of pre-eclampsia Hence, this study was designed to evaluate serum uric acid, blood urea and creatinine levels in the prediction of Pre-eclampsia (PE) and Eclampsia. A hospital-based case-control study was conducted among pregnant women’s. A simple random sampling technique was applied to select study participants. The clinical data were collected. Serum samples were used to determine the maternal uric acid, urea and creatinine levels via an automated chemistry analyzer. Independent sample t-test, Pearson correlation test analysis were performed to check the association and diagnostic accuracy of variables Eclampsia to pre- eclampsia. The mean ages (in years) of the case and control groups were 17 to 20 age group with 11, 12 & 06 patients, 21 to25 age group with 33,11 & 17 patients, and 26 to31 age group with 6, 02 & 03 patients of controls, pre- eclampsia and eclampsia respectively. The above geographical distribution of patients. In pre-eclampsia 21 is rural & 04 is urban and in eclampsia 25 is rural & 01 is urban and no one is found in tribal. The age wise comparison of uric acid, urea and creatinine of cases in pre-eclampsia. The most deviation is shown by age group 26 to 31. The comparison of all parameters in controls and cases of pre-eclampsia. The Uric acid 9.676±3.376, urea 44.544±9.152 and creatinine1.2560±0.3841 are highly significant in cases as compared to control group of Uric Acid 3.3145±0.910 Urea 30.168±8.287 and Creatinine 0.7366±0.1686 comparison of all parameters in control and cases of eclampsia. Uric acid, urea and creatinine are highly significant in cases as compared to control groups respectively. In this study, Uric acid is found to be highly significant in 2nd and 3rd age group (P<0.001) and not significant in 1st and 2nd & 3rd and 1st age group. Urea is found to be highly significant in all compared age group (P<0.001). Creatinine is found to be not significant in any compared age group in Pre -eclampsia patients and Uric acid is found to be not significant in any compared age group. Urea is found to be highly significant in 2nd and 3rd age group (P<0.001) and not significant in 1st and 2nd & 3rd and 1st age group. Creatinine is found to be not significant in any age group of eclampsia Patients. But their inclusion in routine diagnostic test to eclampsia & Pre-eclampsia requires large-scale multi-center prospective studies that corroborate our findings.