Abstract : Salacialehmbachii has been used in traditional medicine to treat malaria and anaemia, convulsion, pains, inflammation, respiratory disorders, and other health challenges. This study evaluated the antiplasmodial activity and hematological parameters in Plasmodium berghei-infected mice treated with ethanol root extract of S.lehmbachii. Sixty healthy Swiss mice were used for this study. The 4-day suppressivetest, curative effects against established rodent malaria infection in mice models and haematological indices. The animals were treated with 20 mL/kg of distilled water, chloroquine 10 mg/kg, 50 mg/kg, 100 mg/kg and 200 mg/g of the ethanol root extract, respectively. The extract at varying doses, significantly (p<0.05 and p<0.01) exhibited a dose-dependent decrease in parasitemia in suppressive and curative studies. Chloroquineat 10 mg/kg significantly (p<0.01) decreased parasitemia levels in the two models of malaria infections. The effect elicited by the extract against plasmodium is equivalent to standard drug in terms comparison. There was a significant increase (p<0.01) in hematological indices. However, there was also a decrease (P <0.05) in WBC and its differentials. The secondary metabolites revealed potential phytoconstituents. The extract was found to be non-toxic in mice at 5000 mg/kg. The findings show that S. Lehmbachiiethanol root extract demonstrated high antiplasmodial activity in a dose-dependent fashion and improved hematological indicesin plasmodia infected mice.