Childhood-onset SLE is characterized by periods of flares and remissions. The SLEDAI score is one of the systems used to assess SLE activity. Long-term use of high-dose corticosteroids is associated with an increased risk of infection, metabolic and musculoskeletal diseases. This condition can cause non-adherence to taking medication in SLE patients. Medication adherence was assessed using the MMAS-8 Questionnaire. The study is to determine the association between medication adherence of oral corticosteroids based on MMAS-8 score with SLEDAI scores in SLE children at H. Adam Malik Hospital Medan. A retrospective observational study on 21 SLE children at Haji Adam Malik Hospital Medan who had received corticosteroid treatment for at least 3 months from May to July 2022. SLEDAI scores and adherence to corticosteroid medication were assessed using the MMAS-8 questionnaire. 21 samples were assessed for SLEDAI scores and adherence to taking corticosteroid medications using the MMAS-8 questionnaire. Most of the subjects showed a high level of compliance amounting to 9 people (42.9%). Kruskal Wallis test showed that there was a significant relationship between the level of treatment adherence and SLE disease activity at control time (p = 0.002). The Wilcoxon test showed that there was no difference in the mean score of SLEDAI between before and after treatment (p = 0.057). There is a relationship between medication adherence of oral corticosteroids based on MMAS-8 score with SLEDAI scores in SLE children at H. Adam Malik Hospital Medan.