To determinate the purity and antibiotic composition on farm-raised honey in Quang Ngai province. Acacia honey is harvested in Minh Long district, Quang Ngai province during the rainy and dry seasons. The chemical composition and antibiotic content in final products are accurately low in the limit of detection (LOD) and limit of quantitation (LOQ). They are validated to be technically suitable for consumer according to the guidelines provided by the Association of Official Analytical Chemists (AOAC) and the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH). The result of analysis of chemical components of the studied honey shows that the C4 sugar content ranges from 3.1 to 5.2%, which is within the range of pure honey. The Fluoroquinolones Antibiotic Group, including Ciprofloxacin, Danofloxacin, Difloxacin, Enoxacin, Enrofloxacin, Flumequin, Gatifloxacin, Levofloxacin, Lomefloxacin, Marbofloxacin, Nalidixic Acid, Norfloxacin, Orbifloxacin, Oxolinic Acid, Pefloxacin, Sarafloxacin, as well as some other antibiotics such as Sparfloxacin, Chloramphenicol, and Streptomycin, are almost undetectable. Research results indicate that farm-raised honey is safe for consumer.