Abstract : Congenital hypothyroidism (CH) is one of the most common preventable causes of intellectual disability worldwide. The present study aims to study subjects with congenital hyperthyroidism with their clinical, etiological and demographical profile. Correlations between age at first treatment, length of treatment, initial levothyroxine (LT4) dose, and serum free thyroxine (fT4) and thyroid stimulating hormone (TSH) levels and pediatric quality of life in patients with CH. 51 children diagnosed with Congenital hypothyroidism attending MS Ramaiah Endocrinology OPD. The aetiology of Hypothyroidism was Dysgenesis, Complete Agenesis, Dyshormonogenesis, Ectopic thyroid and unknown etiology in 17(33.3%), 7(13.7%), 2(3.9%), 8(15.6%) and 9(17.6%) children respectively. Our group had a mean Qol score more than 70 in all domains assessed. The mean physical, social, emotional, school and psychosocial domain functioning scores were 78.5, 74.51,77.1, 83.69 and 235.1 respectively. There was statistically significant co-relation between Age of initial treatment with physical, social and psychosocial domains. The length of treatment co-related with physical and psychosocial domains. Mean initial TSH ft4 levels and initial dose of Levothyroxine did not show significant co-relation with any of the domains.