Neonatal septicemia is of clinical importance due to its characterized signs of associated infection in the first month of life. This study comparatively examined serum granulocytes, C - reactive protein (CRP) and body weight changes (BWC) in pregnant mothers and their septicemic and non-septicemic neonates at birth. A total of 492 apparently healthy pregnant women and their newborns were ethically recruited and assessed for sepsis at gestational weeks 37, 38 and 39. Umbilical cord serum samples of neonates was obtained during delivery and assayed for CRP levels, polymorphs (basophil, neutrophil and eosinophils) and BWC. Neonates were monitored for 28 days to identify those who will come up septicemic. Mothers of septisemic and non-septicemic neonates, as well as their new-borns formed the experimental and control groups respectively. At 37th week of gestation, study found no significant increase (p = 0.9808) in maternal CRP relative to 38th and 39th weeks. For mothers of non-septicemic neonates, a significant decrease (p = 0.0000) was observed in CRP at weeks 2, 3 and 4 compared to week 1 post birth. ANOVA returned a insignificant increase for assessed granulocytes but eosinophil which increased significantly (p = 0.0450) with increasing pregnancy age. Mothers of septicemic neonates showed no significant change in polymorphs during pregnancy. Sepsis has effect on CRP during pregnancy and should be used with polymorph granulocytes during pregnancy as a routine diagnostic marker in the event of suspicion of septicemia.