This study aimed to compare the frictional force generated between different combinations of epoxy-coated and stainless steel archwires in ceramic and stainless steel brackets. Stainless steel brackets (SSB) and ceramic brackets (CB) of slot size 0.022x0.030″ Roth prescription was used. The brackets were connected with two types of arch wires stainless steel archwire (SSA) with a gauge of 0.019x0.025″ and tooth tone epoxy-coated stainless steel archwires (ECSSA), ligated with conventional elastomeric ligatures. Four combinations of brackets and archwires were produced. The frictional test was performed using a universal testing machine for a distance of 5 mm at a speed of 5 mm/minute in the presence of artificial saliva. CB with ECSSA shows the highest mean frictional resistance (3.6 N), followed by CB with SSA (2.2 N). The SSB with ECSSA showed a mean frictional force of (1.8 N), and the SSB and SSA showed the lowest friction (1.5 N). One-way ANOVA showed a significant difference between the tested groups (P=value: 0.01). Tukey's Post HOC test demonstrated significant differences between SSB and ECSSA with CB and ECSSA, CB and ECSSA with SSB and SSA bracket. This study's results confirm that the least frictional resistance was associated with stainless steel wires and brackets. The highest frictional focus was on ceramic brackets and epoxy-coated stainless steel wires.