Abstract : Neonatal jaundice is a common clinical problem during the neonatal period, especially in the first week of life. Healthy infants can develop idiopathic neonatal jaundice with prevalence of 60% - 80%. The liver is the site of albumin synthesis which binds unconjugated bilirubin from the breakdown of erythrocytes and helps in transport to the liver. Low albumin production will reduce the transport and binding capacity. To determine the relationship between umbilical cord blood albumin levels and the occurrence of neonatal jaundice in term newborns. Prospective cohort of term neonates with normal birth weight of 2500-4000 grams from February 2020 until December 2020 at the RSUP. H. Adam Malik Medan according to the inclusion and exclusion criteria. To assess the correlation between two variables using Pearson correlation test with alternative spearman correlation test followed by simple linear regression. A total of 38 newborns were analyzed and 20 newborns met the inclusion criteria. The correlation of umbilical cord blood albumin levels with total serum bilirubin and indirect bilirubin levels on the third day showed a negative correlation (r value -0.759 and r -0.851) with p value <0.001 indicating a significant correlation. Meanwhile, there was no significant correlation between umbilical cord blood albumin and direct bilirubin with r value is -0,442 and p value is 0.051. The regression equation obtained is indirect bilirubin = 23,007 – 4,108 umbilical cord albumin levels. Indirect bilirubin levels can be estimated based on the value of umbilical cord albumin.