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Abstract : There is widespread agreement that Helicobacter pylori causes gastritis and sometimes cancer of stomach lining. The purpose of this investigation is to examine relationship between H. pylori positivity and colon cancer, or ulcerative colitis, as well as involvement of interleukin-17 and interleukin-21, and cytotoxin-associated-gene A (CagA). A sample of 84 patients were split into three groups: ulcerative colitis (UC) patients, colon cancer (CC) patients and control group of who seemed to be in good health. H. pylori was identified according to microbiological methods. Then, interleukin 17, interleukin 21 and CagA were measured by ELISA technique. Expression of H. pylori containing CagA showed highly significant differences in patients with CC (72.1 5.2) and UC (68.9 ± 1.6) compared to healthy patients (0.5 ± 0.2). Serum interleukin17 and interleukin21 levels were highly significantly increased in patients with positive H.pylori status (30.9 ± 1.9 and 25.3 ± 1.7) compared to negative status (7.1 ± 0.5 and 6.7 ± 0.7). The interleukin17 and interleukin21 level in H.pylori CagA status (63.1 ± 5.5 and 39.9 ± 1.1) were significantly increased compared to negative CagA (32.5 ± 1.0 and 27.6 ± 0.8). The level of interleukin17 in colon cancer and ulcerative colitis (25.5 ± 2.3 and 20.6 ± 1.0 respectively) was significantly increased as compared with control patients (6.2 ± 2.0). However, the level of interleukin 21 showed a significant difference between colon cancer (22.1 ± 2.2) and control group (12.6 ± 0.9). interleukins 17 and 21 have shown to be significantly positively correlated in H.pylori patients with colon cancer and ulcerative colitis. Furthermore, there was a correlation between ulcerative colitis and colon cancer in patients without H. pylori infection. Interleukin 17 together with Interleukin 21 play a vital role in inflammation. Thus, correlate with ulcerative colitis and colon cancer either directly or indirectly.