Abstract : Post-operative pericardial adhesion remains a serious cardiac surgery complication leading to higher morbidity and mortality. Fibrous adhesions can destroy tissue planes and disturb the adjacent vasculature structure, prolonged of surgical time, and increased medical costs. While animal-based models are essential for studying the prevention of post-operative pericardial adhesions, several yet limited animal model and clinical human intervention to evaluate the role of bovine pericardium (BP), especially decellularized patch, has been established. In order to address these unstructured evidences, a literature review in regard to post-operative pericardial adhesions was conducted. Three main databases of PubMed, Google Scholar, and ScienceDirect with advance search method using Boolean Logic “AND” of selected keywords were employed. Out of 7 articles that met our review criteria, all of them present that BP showed potential significant role to prevent adhesion. Furthermore its elasticity, handling characteristics, and the lower risk of endocarditis. Thus, BP can reduce the fibrosis and focal inflammation during post-surgical healing process of the pericardium with the average optimum outcome within 2 weeks, with the shortest time being 10 days and the longest being 12 months. Decellularized bovine pericardium has the ability to speed up tissue regeneration and angiogenesis within implanted pericardial substitute. This quality may accelerate the bovine pericardium inner surface remesothelialization and eventually prevent pericardial adhesions to the adjacent epicardium.