A global pandemic, diabetes mellitus DM is growing in prevalence and importance. Many pathogenic pathways contribute to the onset of this disease, and these processes may be impacted by genetic, epigenetic, and environmental factors. Protein glycation processes that are non-enzymatic have been closely linked to the development of chronic complications due to diabetes. Fructosamine 3-kinase has been identified (FN3K), A new method of protein repair called protein deglycation involves an enzyme that is of tremendous interest. Fructosamines become unstable and separate from proteins when FN3K phosphorylates them on the third carbon of their sugar moiety. Here we argue about enzyme activity and its comparison in control group and patients with type 2 diabetes and enzyme activity in control group according to sex, age and BMI and about the existence of an inverse relationship between activity of enzyme and glycated hemoglobin also Comparison of clinical parameters Include Insulin, insulin resistance, HbA1c and Fructosamine between control and DM type 2.