Glomerulonephritis is a disease of inflammation on kidney’s glomerulus that is marked by the damage of glomerular capillary wall, increase of membrane permeability, and decrease of glomerular filtration rate. Glomerulonephritis needs to be detected and treated early to minimize kidney damage. Chronic glomerulonephritis can slowly be progressive and periodically cause the loss of kidney function. Oxidative stress and inflammation is known to have a role in the pathogenesis of Acute Glomerulonephritis. Andaliman fruit (Zanthoxylum acanthopodium DC) is known to have plenty of benefits, namely as antioxidant and anti-inflammation. To determine the effect of andaliman fruit ethanol extract towards measurement of creatine, urea, and kidney histologic structure on mice models with acute glomerulonephritis. Research design is an experimental study using the pretest posttest with control group design method on Streptokinase induced acute glomerulonephritis Rattus norvegicus rat model. This study compares the effect of andaliman fruit ethanol extract on control group and treatment group receiving each the dose of 100 mg/kg/day, 200 mg/kg/day and 300 mg/kg/day. There was a significant difference (p<0.05) creatinine and urea level between groups after given the andaliman fruit ethanol extract on acute glomerulonephritis rat model after 14 days. The most effective change on kidney histologic structure could be seen in a group receiving the dose of 100 mg/kg/day. This study showed the anti-inflammatory activity of andaliman fruit (Zanthoxylum acanthopodium DC) that could be seen from the improvement of kidney function and histologic structure.