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Abstract : The aim of this study is to evaluate the antihyperlipidemic effect of Phytosterolsfraction of Iraqi Cicerareitinum in high-fat diet (HFD)-fed mice. Animals were divided into (4) groups, for each group (n =8). The total duration of the study was (56) days split into two intervals. During the first 28-days interval, mice were administered with HFD, whereas during the second 28-days interval, they were co-administered HFD plusPhytosterols (500mg/kg: p.o.) or the standard drug Atorvastatin(10mg/kg: p.o.). Phytosterolstreatment to HFD-induced hyperlipidemic mice caused a high significant decrease in the levels of total cholesterol (TC), triglycerides (TG), LDL-C and VLDL-C. Moreover, Phytosterolsresulted in a high significant increase in the levels of HDL-C, whereas it caused remarkable decreases in ALT, AST and ALP enzymatic activities also in total serum bilirubin (TSB) levels among hyperlipidemic mice. Besides that, Phytosterolstreatment showed significant improvement in levels of tissue MDA and GSH in hyperlipidemic mice. Histopathological examination of hyperlipidemic mice group showed marked and diffused cytoplasmic fatty infiltration which was all ameliorated by Phytosterolsadministration. The results revealed that Phytosterols(500mg/kg; p.o) possess potential ameliorating benefits against hyperlipidemia induced by HFD on lipid profile, liver function enzymes, oxidative stress parameters, hepatic and aorta histoarchitecture. Further investigations are recommended to assess the efficacy and to fully dissect the mode of action the observed anti-hyperlipidemic effect of Phytosterols.