Pain in labor for a certain period time will be traumatizing and can hinder daily activities, have an impact on the decline in maternal welfare, lack of bonding between mother and baby. This study aims to determine the effectiveness of mindfulness interventions on labor pain through a systematic review. The method used in this study is a systematic review by searching articles through Pubmed, ProQuest, Science Direct, Wiley Library, Sage Journal, and Cochrane Library databases with publication years from January 2012 to January 2022. The results obtained 9 articles that matched the inclusion criteria, 3 articles from Amsterdam, 2 articles from Australia, 2 articles from Iran, 1 article from India, and 1 article from the USA. The use of mindfulness interventions for mothers who are afraid of childbirth states that mindfulness interventions are effective in reducing labor pain. From this study, it can be concluded that mindfulness for the future can be used as a non-pharmacological intervention option to reduce labor pain without risky side effects. Researchers suggest that further research is needed on the long-term effects after delivery and delivery outcomes.