Abstract : The use of synthetic chemical pesticides to maximize agricultural yields is very susceptible to negative effects on health. Exposure to DDT, BHC, HCB, organochlorine and mirex compounds from pesticides has been reported to trigger diabetes mellitus. However, mixed results make estimates of pesticide effects not always consistent. The purpose of this study is to find out more reliable analysis and estimation. Based on this background, researchers are interested in conducting a meta-analysis. The research was searched from several indexes including: PubMed, Science Direct, Web of Science, Springer Link and Cochrane Database. By using the search keywords “organochlorine pesticide AND Diabetes mellitus”, “organophosphate pesticide AND Diabetes mellitus”, “organochlorine pesticide AND Diabetes mellitus AND adjusted odds ratio”, and “organochlorine pesticide AND Diabetes mellitus AND adjusted odds ratio”. Population: Everyone over 20 years old. Intervention: Exposure to pesticides. Outcome: Type 2 Diabetes Mellitus. 8 articles that met the quantitative requirements indicated that pesticides were a risk factor for diabetes mellitus (DM). Individuals exposed to pesticides had a 1.57 times risk of developing DM compared to people not exposed to pesticides (aOR= 1.57; 95% CI= 1.11 to 2.22; p= 0.010). The funnel plot shows that there is publication bias which indicates a tendency to overestimate the effect. Individuals who were exposed to pesticides had a 1.57 times risk of developing DM compared to people who were not exposed to pesticides and it was statistically significant.