Necrotizing cellulitis is a necrotizing infection with or without gas formation localized to the skin and subcutaneous tissue but does not involve the underlying fascia and muscles. Management should prioritize timely diagnosis and intervention with appropriate management and antibiotics. It is reported that a 67-year-old male patient with necrotizing cellulitis on the left leg with culture results of staphylococcus aureus was given broad-spectrum systemic antibiotic therapy according to the sensitivity results and treated using absorbent dressing in the form of foam and a combination of platelet-rich plasma (PRP) and polyhexamethylene. Biguanide (PHMB) makes granulation tissue appear rapidly and re-epithelializes complete in 8 weeks. Necrotizing cellulitis is an infection with a lot of exudates and necrotic tissue. Excessive wound infection and exudation were treated with systemic antibiotics and absorbent dressings, and the combination of PRP and PHMB can increase the efficacy of therapy by increasing the granulation tissue formation and epithelialization of wound healing. The success of absorbent dressing therapy and the combination of PRP with PHMB can provide satisfactory therapeutic results and can help the process of new tissue formation and complete epithelialization of necrotizing cellulitis ulcers in 8 weeks.