Abstract : Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that primarily manifests in the joints but can also spread to other organs and tissues throughout the body. A possible connection between RA and depression has been suggested by recent research. Depression is more common in people with RA than the general population, and it's been linked to worsened symptoms like pain and fatigue as well as decreased satisfaction with life overall, more physical limitations, and higher medical bills. The purpose of this study is to determine the prevalence of depression among patients with a confirmed diagnosis of rheumatoid arthritis, as well as to examine the correlation between depression and disease activity. In this case-control study, 50 patients with a confirmed diagnosis of RA according to the ACR/EULAR criteria for Rheumatoid Arthritis were matched with 50 healthy individuals. Questionnaires and in-person interviews were used to compile the data. The PHQ-9 is a validated measure of depression according to the DSM-IV criteria. The Clinical Disease Activity Index was used to quantify disease burden (CDAI). The average ages of the patients and controls were 47.3 (12.8) and 38.1, respectively. There were 39 depressed patients out of 50 total, but only 22 depressed controls. Patients with RA had an increased risk of clinical depression and its symptoms were related to disease activity. Patients with rheumatoid arthritis were found to have a disproportionately high rate of depression, and this was linked to worsened disease outcomes.