Lower respiratory tract infections (LRTIs) caused by the influenza virus are associated with significant mortality and morbidity. We sought to generate estimates of the burden and cost of influenza-associated LRTIs in Indonesia in 2017. Data from Indonesian influenza sentinel sites and hospitals not designated as sentinel sites, and published demographic data for Indonesia were used to estimate the incidence of LRTIs attributable to influenza by applying the Global Burden of Disease (GBD) methods. The cost of influenza LRTI associated illness, disability, and premature death was used to estimate the macroeconomic burden. Direct health care expenditures for ambulatory services and hospitalization were also calculated. We estimated that in 2017 1,285 episodes of LRTIs were attributable to influenza per 100,000 LRTI episodes (a total of 3,358,418 episodes). Of these, 121,305 (3.6%) were detected from ambulatory healthcare visits and 40,435 (1.2%) were hospitalizations. The case fatality rate was 0.122 per 100 cases, a total of 4,097 deaths. Total medical expenditure (out-patients and hospitalized patients) was estimated as 19,235,240 USD, and the DALYs lost were 223,506 years or 859.79 million USD. The total economic cost due to influenza in Indonesia in 2017 was estimated as 878.99 million USD. This study estimates a considerable burden of disease related to LRTIs due to influenza, associated with a substantial productivity loss and healthcare costs in Indonesia. Our results highlight the significant impact that influenza prevention strategy, such as immunization, could have on current health and economic loss in Indonesia.