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Abstract : Helicobacter pylori has been detected in the laryngeal areas in clinical investigations. As a result, the goal of this study was to isolate and identify H. pylori infection in laryngeal biopsy from patients with benign laryngeal polyps (BLP) and laryngeal squamous cell cancer (LSCC) as compared with healthy people (control). A study was conducted on 50 patients suffering from squamous cells carcinoma of the larynx and 36 patients suffering from benign laryngeal polyps (BLP) compared with 12 healthy people or control. Highly significant (P<0.01) variations in H. pylori infection among LSCC, BLP and control that recorded 42%, 30.5% and 16.6%, respectively. mRNA IHC expression showed a highly significant elevation of LSCC patients and record 71.2 ± 4.2 as compared with 20.6 ± 1.1 recorded to BLP patients. IL-17 expression by IHC technique with and without H. pylori showed highly significant elevation (P<0.01) in the LSCC group compared with BLP and control. Correlation of IL-17 protein expression among the studied group with and without H. pylori showed significant (P<0.05) elevation in LSCC and BLP IL-17 level as compared with control. H. pylori can inhabit the larynx of the patients having laryngeal squamous cell carcinoma and benign laryngeal polyps, according to the findings. More investigation is required, however, to determine the role of H. pylori as a risk factor for disorders of the larynx.