Abstract : Decisions on COVID- 19 vaccines can be influenced by uncertainty, the spread of rumors, and false information. Therefore, this study aims to assess the knowledge, attitude, and vaccination status of the COVID-19 vaccines among adults in Karbala province. A cross-sectional descriptive study with analytic elements was conducted in Karbala province, among 400 participants aged 18 years and above. Samples were taken from two categories of working groups, paramedical and non-paramedical staff. The survey was conducted from March 2022 to May 2022 using a structured questionnaire. The statistical analysis was performed using the Statistical Package for Social Sciences software. A p-value of less than 0.05 is regarded as significant. The findings indicate that (66.25%) of the study participants had good knowledge about people eligible for COVID- 19 vaccines, a higher percentage (90.75 %) believed that adults over 18 years are eligible for the vaccine, and a lower percentage believed that pregnant (18%) and lactating women (16.75%) are eligible for the vaccine. (73%) of the participants received the COVID-19 vaccine and the Pfizer vaccine was the most popular choice. Besides, (70.75%) of participants identified social media as their primary source of knowledge about the COVID -19 vaccines. About two-thirds of the study's participants had good knowledge, and about (59.2%) of them had a good attitude regarding COVID-19 vaccines, with a vaccination acceptance rate of 80%.