Pathological evaluation of colorectal cancer resection samples play a vital role in management and prognosis of postoperative cancer patients. Difficulties exist in the assessment and outcomes of these specimens for therapy protocol. PNI is a perineural invasion associated with increased mortality in many malignancies including colon cancer. In colorectal cancer (CRC) and nearby tissue, PNI evaluation as a potential prognostic indicator with the use of CD 166 stem cell marker remains to be clearly defined for providing a convenient information for future management and prognosis. The incidence and significance of histological neural invasion in nearby tissue was conducted in 52 patients with colorectal carcinoma operated on for the period from June 2017 to June 2020 retrospectively. Tumors were subjected to histopathological and immunohistochemical study (IHC)with CD166 stem cell marker for PNI in tissue adjacent to CRC. Data collected and analyzed, histopathological pictures was obtained and studied. Outcomes showed that neural invasion was expressed by Cd166 stem cell marker as strong and severe in patients with stage B and C in tissues nearby tumor which reveals bad prognostic features. Neurogenesis appeared to have a critical role in colorectal cancer progression. furthermore, current results indicated that neurogenesis functions as an independent predictor of outcomes for therapy protocol.