Detection of the phytochemicals in medicinal plants and determining their antibacterial property can lead to drug discovery and development. This study performed ethanolic leaf extract of the ten medicinal plants to identify bioactive compounds and the sample's antibacterial activities. The selected medicinal plants were Pandanus amaryllifolius, Asplenium nidus, Corchurus olitoroius, Schefflera odorata, Adonidia merrillii, Artocarpus altilis, Bixa orellana, Mentha arvensis, Polyscias scutellaria, and Camptostemon philippinensis. Phytochemical screenings of the plant extracts employed standard methods. The potency of the ten sample extracts was obtained through the disc diffusion method against the gram-positive bacteria Staphylococcus epidermidis and Bacillus cereus, and gram-negative bacteria Escherichia coli and Serratia marcescens. Results showed that all plant extracts contained saponins, tannins, coumarins, and glycosides. However, bioactive compound steroids are present in the extracts of P. amaryllifolius, A. nidus, A. merrillii, A. altilis, and B. orellana. Antimicrobial activities of the plant extracts revealed that A. nidus has the highest potency against S. marcescens at 10mg/ml and its minimum inhibitory concentration (MIC) at 5mg/ml with 18.67.33mm 16.33mm zone of inhibition, respectively. Escherichia coli showed considerable susceptibility to S. odorata extracts at the 5mg/ml MIC with 9.83mm inhibition. Thus, these are implications that the plant extracts containing specific phytochemicals beneficial to human health to develop into potential medicine against the susceptible bacteria.