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Abstract : Psoriasis is an autoimmune disease characterized by the proliferation of keratinocytes throughout time. On average, it affects 2-5 % of the world's population. Psoriasis treatment remains difficult due to a variety of factors influencing treatment, including patient compliance and therapy adherence, profiles of delicate patients, psychological factors, and topical delivery skin work as a barrier. Topical therapy is the most common treatment choice, and it has few side effects. Biological therapy has improved the efficacy of traditional psoriasis treatment and enhanced patient acceptance due to fewer side effects. Nano formulations have an advantage over traditional therapy since they have a better anti-psoriatic effect and fewer adverse effects. Psoriasis symptoms can be reduced with phytopharmaceuticals as a supplemental and alternative therapy. In the present review, we are summarizing the most important types of psoriasis therapy.