Abstract : The purpose of this paper is to provide a detailed overview of the pharmacology, phytochemistry, and botanical description of Hamelia patens. Hamelia patens Jacq. [Syn. H. erecta Jacq. (Rubiaceae)] is a big evergreen shrub. It was brought to India and planted in gardens as an ornamental plant. It is a perennial bush that may flourish both in the sun and the shade. The extract was made from Hamelia Patens (aerial parts) and through some chemical processing before being put through a physiochemical evaluation, including measuring for foreign organic matter, ash values, extractive values, moisture content, swelling, and foaming index. Similar results indicated that the foaming index was below 100. Comparing total ash to acid insoluble and water-soluble ash, the greatest amount was found to be 3.133. The phytochemical experiment used n-Hexane, chloroform, ethyl acetate, ethanol, and water as more polar solvents for Soxhlet extraction. Flavanoids, alkaloids, carbohydrate tannins, steroids, and starch were found during the preliminary qualitative phytochemical screening. Pharmacological research on Hamelia Patens' in vivo nephroprotective efficacy was included (Aerial parts). The result revealed that the drug has potent phytoconstituents such as flavonoids viz: ruitn, quercetin, and other phytochemicals. Future studies should evaluate the safety and efficacy of the medicine through clinical studies, data-driven pharmacological analysis, and the isolation of the active phytoconstituents responsible for its diverse therapeutic action.