Abstract : Existing reports are speculative on the gastro-protective actions of quercetin (QCT) flavonoid and its potency in ulcer healing as employed in modern ethno-medicine. Forty five (45) matured female wistar rats (150-200g) were acclimatized for 2 weeks, fed standard rat chow ad libitum, and assigned into 9 groups of 5 rats each. With group 1 being control, groups 3 – 9 (experimental) were fed varying doses of QCT after inducing gastrotoxicity (ulcer) with indomethacin. Whilst group 2 animals formed negative control group (untreated). Groups 3 – 9 respectively received 40 mg/kg of QCT, 60 mg/kg QCT, 80 mg/kg QCT, vitamin C, vitamin C + 40 mg/kg QCT, vitamin C + 60 mg/kg QCT, and vitamin C + 80 mg/kg of QCT treatments for 3 weeks after ulcer confirmation. After treatment periods, animals were euthanized, stomach harvested, salt-washed and subjected through, gastric volume, motility and pH tests while observing the degrees of ulceration across treatment groups with a 10× magnifying lens, notably at different levels of mucosa lesions (ulcer scoring). The ulcer severity and mucosa lesion were also observed to full erosive ranges at different extremes, while calculating QCT and/or vitamin C treatments from the curative ratio. Statistical mean differences was conducted for each group, using the one-way analysis of variance (ANOVA). All calculations were assessed at 0.05 confidence, with p-value < 0.05 adjudged as statistically significant. From the result, ANOVA returned a statistically insignificant decrease in gastric volume of gastrotoxic untreated animals (negative control) relative control. This increased significantly (p < 0.05) with QCT + vitamin C co-administrations as compared with untreated animals. Also, a statistically significant increase (p < 0.05) was noted in gastric pH for untreated animals relative control. This decreased significantly (p < 0.05) with QCT + vitamin C co-administrations except in 60mg QCT + vitamin C treats compared with untreated animals. Gastric emptying decreased insignificantly in ulceric, untreated animals as compared with control group. Thus, QCT + Vit. C co-administrations proved potent and efficacious in ulcer healing, relative to single QCT treatment option. Similar studies on the Gut-Brain axis for QCT-vitamin C treatments at varying doses is recommended.