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Abstract : Musculoskeletal diseases, which affect men and women equally, are regarded as a common underlying cause of physical impairment in society. The knee, being one of the most complex synovial joints, is vulnerable to a great deal of stress from everyday activities. When radiographs are negative or inconclusive and a patient has acute non-traumatic knee pain. MR imaging is the preferred option for further testing. The most common diseases that impact the subchondral knee joint, together with their likely etiologies and MR imaging findings, are discussed here as it is critical to distinguish them early on in order to avoid unnecessary and excessive treatment.