The COVID-19 pandemic had a dramatic effect on health, economic growth, employment, and way of life worldwide. To measure the effect of the coronavirus oandemic on STIs in public healthcare, multiple studies have been carried out concerning key elements, such as: challenges and management. To review literature focused on studies in global and national aspects concerning initiatives in public healthcare to curb the coronavirus pandemic and at the same time have an effect on the levels of sexually transmissive infections. A review of studies has been carried out for the period January 2020 - November 2022 in databases PubMed, and Google Scholar, as well as data from international and national platforms with the following keywords: “COVID-19”, “STI”, “Challenges”,” Management”. The review outlines the conceptual framework of the issue on a global level. The majority of authors take into consideration major points such as management and challenges to them concerning the coronavirus pandemic and STI. Major challenges to the management of the most common STI in relation to the COVID-19 pandemic and the measures for curbing it have been presented and discussed. The global COVID-19 pandemic and STIs have their intersection point consisting of significant effects on the prevention, therapy, and monitoring of these diseases. At the same time, there are no sufficient studies on the topic about lower-income countries, аnd high-risk social groups.