Abstract : Pro-protein convertase subtilisin kexin-9 (PCSK9) is a protein that regulates the expression of low-density lipoprotein receptors (LDLR) and has critical role in the initiation and progression of the atherosclerotic process. This study aimed to quantify the concentration of PCSK9 protein, total lipid profile and fasting blood glucose (FBG) levels in the serum sample of Iraqi patient with atherosclerotic coronary artery disease (ASCAD) and compared to healthy control groups. The present study include 150 participant (100 patient with ASCAD and 50 control), their ages ranged from 30 to 65 years, the PCSK9 levels estimated by ELISA technique, while lipid profile and FBG determined through routine laboratory methods. The results showed that was a high PCSK9 levels in a patient group comparison to healthy controls group (P= 0.00), while lipid profile serum levels (TC, TG, LDL-C, VLDL and HDL-C) and fasting blood sugar displayed a highly significant difference were compared between patients with ASCAD and control group. According to the findings of serum PCSK9 levels may be consider a better predictors for coronary artery disease.