The study was performed to evaluate the Epidemiological status of cutaneous leishmaniasis in the Al-Kifil district /Babylon province during the period 1/9/2017 to 1/3/2018, 106 cases visited the Al-kifil general hospital and some private clinics in this district were studied. The infestation was diagnosed by dermatologist physician, The study was performed to evaluate the Epidemiological status of cutaneous leishmaniasis and evaluation some hematological parameter changes of infected persons with cutaneous leishmaniasis in the Al-Kifil city /Babylon governorate during the period 1/9/2017 to 1/3/2018 500 cases visited the Al-kifil general hospital and some private clinics in this city were studied. The infection was diagnosed by dermatologist physician, all similar cases to cutaneous leishmaniasis were excluded. 106 positive case with cutaneous leishmaniasis were examined from patient with the disease referring to Al-kifil general hospital and private clinics. The study revealed that the percentage of infection with cutaneous leishmaniasis was 21%. The percentage of infection with the CL was 40% with the age 1-14 year and 10% with age 15-40. Male were more infected with the disease (65%) than female (35%). Rural area were more epidemic with this disease (55%) in comparing with area near Al-kifel city (25%) and inside Al-kifil city (20%) respectively. Arms and legs were more exposed to infection (60%) with ulcer than head (40%). Multiple ulcer represent more prevalence in the body (60%) comparing with the single (40%). Wet ulcer were more prevalent in incidence of infection (83%) in the Al-kifil community in comparing with dry ulcer (17%). Venous blood was drawn patient with cutaneous leishmaniasis for determination of some blood parameter (hemoglobin, pact cell volume, platelet, white blood cells, eosinophil cells, lymphocytes, neutrophil cells, and neutrophil/ lymphocyte ratio) and IgM, IgG, and IgA. The mean level of Hb and PCV was significantly decrease in patient with cutaneous leishmaniasis (Hb=12.05), (PCV=23.68) in comparison with the control group, while there was an increase in (platelet=269000, WBC=6500, eosinophil=0.26 k/l, lymphocyte=0.35 k/l, neutrophil=5.71 k/l, and neutrophil/lymphocyte ratio=2.23). The result also revealed a significant decrease in (IgG,=0.3 g/l, IgM=0.25 g/l) respectively but no change in IgA value was notice.