Abstract : Mercury chloride can cause nephrotoxicity, increase ROS, MDA, and decrease TGF-β resulting in tubular cell membrane damage. The metallothionein protein found in IR Bagendit rice leaves can bind mercury and coconut water contains lots of antioxidants. The aim of this study was to find out how the infusion of IR Bagendit rice leaves and coconut water improves kidney damage. The experimental study on Rattus nurvegicus rats used in the experiment was divided into five groups: negative, positive control, and treatment 1, 2, and 3. Each group contained six rats. The negative control group was given only a placebo. The positive control group received a daily dose of HgCl2 20 mg/day/kg BW. Treatments 1, 2, and 3 each received 0.2 ml, 0.4 ml, 0.8 ml of water extract of rice leaves of IR Bagendit and coconut water up to 4 ml/100 g BW, all treatment groups were exposed to mercury chloride 20 mg/kg body weight per day. All groups had their blood and kidney organs taken on the 15th day. ROS, MDA, TGF-β levels using Elisa, urea, and creatunu using enzymatic. Renal tubular necrosis and degeneration using HE staining. The results showed that when compared with the positive control group, the average ROS, MDA decreased, the average TGF- increased, and the average cell degeneration and cell necrosis decreased. The average levels of urea and creatinine are still within normal limits. In conclusion, rice leaf water extract can improve the morphology and function of kidney cells in Rattus nurvegicus exposed to HgCl2.