Simple febrile seizures account for 80% of all febrile seizures. Simple febrile seizures are characterized by a generalized seizure that lasts less than 15 minutes and does not recur within 24 hours. The study aims to know the complete blood count (CBC) profile in pediatric patients under five who suffer from simple febrile seizures. The study is a descriptive observational method by collecting medical records of children under five who suffer from simple febrile seizures at Idaman Hospital Banjarbaru from October 2020 to September 2022. The study found 51 children, 31 (60.80%) boys and 20 (39.20%) girls. The results showed neutrophilia at 68.20%, eosinopenia at 56.80%, lymphopenia at 50.00%, and anemia at 25.50%. Conclusion: The CBC profile of patients under five who suffer from simple febrile seizures showed neutrophilia, eosinopenia, lymphopenia, and anemia, respectively.