Premature babies are at risk of shortness of breath because their lungs are immature. Asphyxiation due to shortness of breath carries a risk of disruption of cerebral blood flow that can be measured by transcranial Doppler ultrasound. This study used a cross-sectional design of preterm infants with respiratory distress and preterm infants without respiratoy distress treated according to inclusion and exclusion criteria at RSUP H. Adam Malik Medan. All specimens underwent transcranial Doppler ultrasound at the hospital. Statistical analysis using the Mann-Whitney test and t-test for p<0.05 were considered significantly different. This study used a cross-sectional design of preterm infants with and without dyspnea treated in the neonatal intensive care unit and perinatal unit of H. Adam Malik General Hospital, Medan. Baseline data and results for transcranial doppler ultrasound parameters were obtained from medical records from January 2019 to January 2022. Parameter assessment included peak systolic velocity (PSV), end-diastolic velocity (EDV), mean velocity (MV), resistance index (RI), and pulsatility index (PI) are included. Results showed mean ultrasound parameters in preterm infants with respiratory distress and without respiratory distress in ACA were PSV 33.73 vs 35.28 (p = 0.627), EDV 8.4 vs 8.12 (p = 0.718), MV 16.18 vs 16.84. (p = 0.492), PI 1.61 vs 1.64 (p = 0.390), RI 0.74 vs 0.76 (p = 0.787). On the other hand, the mean ultrasound parameter results for MCA were PSV 38.72 vs 40.47 (p = 0.173), EDV 9.93 vs 10.43 (p = 0.574), MV 17.38 vs 18.04 (p = 0.573), PI 1.66 vs 1.66. (p = 0.515) and RI 0.74 vs 0.736 (p = 0.600). Based on statistical tests, t-test and Mann-Whitney showed insignificant results of transcranial ultrasound parameters for both variables (P > 0.05).