Abstract : Wounds were a challenging clinical problem that often caused morbidity and mortality. Apium graveolens (Linn.) was an herbal plant that had anti-oxidant and anti-inflammatory effects which were considered to accelerate the wound healing process. The number of neutrophils and angiogenesis was an element that played an important role in the wound healing process. Thus, the administration of Apium graveolens (Linn.) extract was expected to help in the process of wound healing which could be viewed from the number of neutrophils and angiogenesis. To determine the effect of giving Apium graveolens (Linn.) extract on the number of neutrophils and angiogenesis in incisional wounds of Sprague Dawley rat. This study was an experimental study with "Randomized post test with control group" design in rats given incisional wounds on their backs, and randomly divided into 4 groups (@5 rat). The number of neutrophils and angiogenesis were seen microscopically and assessed by 2 certified pathologists. The data were analyzed using the One Way Anova - Post Hoc hypothesis test. The number of neutrophils and angiogenesis in the Apium graveolens (Linn.) extract group was significantly lower than the group given the cream without extract (p <0.05) and no difference compared to the group given gentamicin 0.1% cream (p >0.05). The group with Apium graveolens (Linn.) extract 70% had the lowest number of neutrophils and angiogenesis compared to other groups (p <0.05). The application of the topical Apium graveolens (Linn.) extract is effective in the incisional wound healing process by decreasing the number of neutrophils and angiogenesis. The application of the topical Apium graveolens (Linn.) extract 70% is more effective than the extract 50%.