Abstract : The Coronavirus disease 2019 (Covid-19) pandemic caused by severe acute respiratory syndrome SARS-CoV-2 has challenged the health systems of countries affected by it. Covid-19 poses an important occupational health risk for health workers. Health workers are the front line in handling the Covid-19 outbreak putting them at risk of infection. This study aims to determine and analyze the risk of treatment for the incidence of Covid-19 in health workers. This research method used a Case Control Study design and was carried out at the Manembo-Nembo Hospital in Bitung, North Sulawesi Province. A sample of 96 people consisting of 48 cases and 48 controls. Sampling was purposive sampling, data collection techniques using questionnaires were applied using kobotoolbox software. Data analysis using the STATA 14 program. The results of the study a significant risk factor for the incidence of Covid-19 was a history of direct patient contact (OR=14.33 95%CI:4.4-53.2; p=0.000), face-to-face (OR=11,66 95%CI: 3.8-39.2; p=0.000), Direct contact with the environment where the patient is treated (OR= 4.42 95% CI: 1.73-11.4; p=0.000). Vaccination status (OR=2.04 95% CI: 0.10-123.06; p=0.557), Comorbid (OR=0.37 95% CI: 0.34-2.4; p=0.238), time of work (OR=0.89, 95% CI: 0.31- 1.53; p=0.811) not a risk factor. The most dominant factor at risk for the occurrence of Covid-19 is a history of direct contact with patients who have been confirmed to have had Covid-19. The high prevalence of health workers who have confirmed Covid-19 has a history of contact with patients with confirmed Covid-19.