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Azerbaijan Medical Journal

(ISSN: 0005-2523)

Azerbaijan medical journal (ISSN: 0005-2523) - is a scopus indexed journal since 1961. The publisher of the journal is Izdatel'stvo Elm by WHO Office in Azerbaijan. Azerbaijan medical journal (AMJ) is also UGC approved. The journal publishes general medicine, health science, psychological, pharmaceutical journals and so on.

Aim and Scope

Azerbaijan Medical Journal

Azerbaijan Medical Journal (ISSN: 0005-2523) - is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to.

Anatomy Physiology Biochemistry Pharmacology Pathology Forensic medicine Microbiology Community Medicine Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases Anaesthesia Cancer research Neurosurgery Orthopedics Gastroenterology Neurology Nephrology Medical education Orthopaedics Paediatrics Reproduction Cardiology Diabetes Surgery Nursing Otolaryngology Dental Psychology Anesthesiology Dermatology Endocrinology Hepatology Urology Venereology Psychiatry Biotechnology Pharmacy ENT Pharmaceutical Chemistry Pharmaceutical Analysis Pharmaceutics Pulmonology Pharmacognosy Pharmaceutical Phatmaceutical Technology Biopharmaceutics Pharmacokinetics Pharmacodynamics Industrial Pharmacy Drug Design Quality Assurance Drug Regulatory Affairs Phytochemistry Drug Delivery Systems Pharmaceutical Nanotechnology Pharmaceutical Microbiology Hospital Pharmacy Clinical Pharmacy Pharmacy Practice Drug Discovery Drug Metabolism Toxicology Clinical Research Pharmacogenomics Phrmacoinformatics Pharmacovigilance< Life Sciences like Chemistry Biomedical Sciences Microbiology Immunology Forensic Epidemiology Oncology Biomedicine Dentistry Physiotherapy Gynaecology Dermatoepidemiology Neuroscience Ophthalmology Sexology Osteology Kinesiology Angiology/Vascular Medicine Critical care Medicine Haematology Infectious Diseases and Vaccinology Bariatrics Pharmacy and Nursing Pharmacognosy and Phytochemistry Radiobiology Clinical immunology Clinical and Hospital Pharmacy Cell Biology Genomics and Proteomics Healthcare Services Healthcare Management Bioinformatics and Biotechnology Geriatric Medicine

Latest Journals

Azerbaijan Medical Journal

Association of the leptin gene (rs7799039) polymorphism with infertility in Iraqi women
Journal ID : AMJ-01-08-2022-10339; Author : Shahad A Bakhet, Mohammed T. Al-Tameemi,
Abstract : Obesity and Type-2 diabetes mellitus regarded chronic metabolic disease and main causes of infertility in women. obesity lead to increase of Leptin hormone level which synthesis by adipose cells and enterocytes and cause systemic hormonal imbalance. Ninety Iraqi women were enrolled as a samples in this study collected from Women's Hospital in Karbala City and teaching hospital and the women and children hospital of Al-Diwaniyah province from October 2020 to January 2021. Sixty infertility women were suffered from obesity and T2DM and 30 were apparently healthy considered as a control. Allele Specific molecular technique was used to detect the LEP rs7799039 genotypes and allele frequency. Study data to analyze by Chi square and odds Ratio and p-value test used to detect significance of the means. genotype result rs7799039 related with GG homozygous associated with obesity compared with diabetes (0 versus 40%; X2 =15, p-value = 0.01) and obesity compare with control (0 versus 26.66%; X2 =9.23, p-value = 0.03). result of rs7799039 related with GA heterozygous associated with obesity compared with diabetes (86.66 versus 40%; X2 =14.06, p-value = 0.0005), and obesity compare with control (73.33 versus 86.66%; X2 =1.66, p-value = 0.20). result of rs7799039 related with AA homozygous associated with obesity compared with control (13.33 versus 0 %; X2 =4.28, p-value = 0.03), and diabetes compare with control (20 versus 0%; X2 =6.66, p-value = 0.01). the result of this study concluded that rs7799039 revealed that GA heterozygous, GG and AA homozygous are associated of incidence infertility that suffered from diabetes and obesity in Iraqi patient women.
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CLOSURE OF BASAL CELL CARCINOMA DEFECTS IN THE NASALIS REGION AND THE DEXTRA INFRA ORBITALIS REGION WITH A COMBINATION OF FOREHEAD FLAP, ROTATION FLAP, AND SKIN GRAFT PARAMEDIAN TECHNIQUES: A CASE REPORT
Journal ID : AMJ-31-07-2022-10337; Author : Anita Indah Sari, Khairuddin Djawad, Airin R, Nurdin Mappewali, Idrianti Idrus,
Abstract : Basal cell carcinoma (BCC) is the most common type of skin cancer and frequently appears in the centre of the face, particularly the nose. Long-term exposure to ultraviolet radiation is a risk factor for BCC. Biopsy findings routinely confirm the clinical diagnosis. Complete surgical resection is most commonly used in the treatment of facial skin cancer, and the methods used for defect closure are primary closure, local flaps and skin grafts. This article reports a 73-year-old man who complained of a blackish spot on the side of the nose and infra-orbitalis dextra that occurred about two years ago. The complaint was accompanied by itching and bleeding when scratched. The patient was diagnosed with basal cell carcinoma from the history, physical examination, dermoscopy examination, and histopathology. The surgery is carried out in two stages: first, Modified MOHS surgery and secondly, defect closure is performed using the Paramedian Forehead Flap, Rotation Flap and Skin Graft. On the 28th day of follow-up, the surgical wound had dried up completely. The combination surgical technique of paramedian forehead flap, rotation flap, and skin graft can be a treatment option in large facial basal cell carcinoma to achieve an excellent cosmetic and functional outcome.
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Serum PCSK9, lipid profile and fasting blood glucose levels in a samples of Iraqi patient and role in developing of atherosclerotic coronary artery disease.
Journal ID : AMJ-31-07-2022-10336; Author : Marwa M. Al-attar, Salwa J. Al-Awadi, Shaimaa Y. Abdulfattah,
Abstract : Pro-protein convertase subtilisin kexin-9 (PCSK9) is a protein that regulates the expression of low-density lipoprotein receptors (LDLR) and has critical role in the initiation and progression of the atherosclerotic process. This study aimed to quantify the concentration of PCSK9 protein, total lipid profile and fasting blood glucose (FBG) levels in the serum sample of Iraqi patient with atherosclerotic coronary artery disease (ASCAD) and compared to healthy control groups. The present study include 150 participant (100 patient with ASCAD and 50 control), their ages ranged from 30 to 65 years, the PCSK9 levels estimated by ELISA technique, while lipid profile and FBG determined through routine laboratory methods. The results showed that was a high PCSK9 levels in a patient group comparison to healthy controls group (P= 0.00), while lipid profile serum levels (TC, TG, LDL-C, VLDL and HDL-C) and fasting blood sugar displayed a highly significant difference were compared between patients with ASCAD and control group. According to the findings of serum PCSK9 levels may be consider a better predictors for coronary artery disease.
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Detection of Gastrointestinal Lesions Causing Iron Deficiency Anemia by Upper With or Without Lower GI Endoscopy in the Egyptian Society
Journal ID : AMJ-31-07-2022-10335; Author : mohamed sayed, mohamed mahmoud Ali, Taha Mohammed Masri, Mahmoud Wahba, Mohamed Badr Hassan,
Abstract : Most gastrointestinal lesions cause iron-deficiency anemia. Endoscopy of the upper and lower digestive tracts is indicated for IDA patients because most sources of gastrointestinal hemorrhage can be found. Clinical history can predict positive GI endoscopic findings, but its sensitivity in detecting specific lesions, including GI neoplasia, is limited. This study included 1064 IDA patients who had upper and lower GI endoscopies to determine the efficacy of upper and lower endoscopy in diagnosing gastrointestinal causes of iron deficiency anemia in Egyptian individuals. According to our findings, the most common cause of Fe deficiency anemia in upper gastrointestinal lesions (39.8 %) was peptic ulcer, whether gastric or duodenal, followed by angiodysplasia (11.85 %). Colorectal cancer (31.4 percent) was the most common cause of Fe deficiency anemia in lower gastrointestinal lesions discovered by colonoscopy, followed by lower gastrointestinal angiodysplasia (2.7 %). There was a high prevalence of neoplasm in IDA patients. 303 of 700 patients with iron deficiency anemia developed gastrointestinal neoplasm, with 82 instances pathologically proving to be upper gastrointestinal adenocarcinoma and 221 cases being colorectal cancer. In 18 IDA patients, combined lesions were seen. Upper and lower GI endoscopies are beneficial in diagnosing Iron deficiency anemia, says this study. In elderly patients with iron deficiency anemia, gastrointestinal cancers are prevalent. Peptic ulcers are the most prevalent upper GI lesion in Egyptians.
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Histopathological Correlation of ABO Blood Type Antigen Expression in Rectum Tissue in Rectal Adenocarcinoma Patients
Journal ID : AMJ-31-07-2022-10334; Author : Albertus Aryo Pradito, Ihwan Kusuma, M. Husni Cangara, Joko Hendarto, Muh Rusdan Jalil,
Abstract : Early detection is essential to reduce cancer mortality worldwide, including rectal cancer. One factor positively correlated with the incidence of rectal adenocarcinoma is the ABO blood group antigen. However, the use of the ABO antigen as a biomarker in colon cancer screening has not been widely studied. This study aimed to analyze the relationship between the expression of ABO blood group antigens in patients with rectal adenocarcinoma based on the immunohistochemical method. The research was conducted using a cross-sectional study method. The expression of ABO blood group antigens in rectal tissue of the patients with rectal adenocarcinoma was analyzed using the immunohistochemical method (streptavidin-biotin-peroxidase method). Rectal tissue was used as a control without tumor (normal rectal tissue). Statistical data analysis used gamma & Somers correlation and Wilcoxon comparison test. There was a significant difference in the expression of ABO blood group antigens in the rectal tissue between the tumor patient group and the control group (p-value = 0.004). There was no significant correlation between gender, age, stage of adenocarcinoma, histopathological degree of adenocarcinoma, and ABO blood group with the degree of antigen expression of tissue ABO blood group. These results were seen in both the control and tumor group (all p values > 0.05). In conclusion, the expression of the ABO blood group antigen in rectal tissue does not correlate with the tumor stage. However, this antigen can potentially be used as a marker of a malignant process.
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The Role of ATM gene in Iraqi Breast Cancer Patients Undergoing Radiotherapy
Journal ID : AMJ-31-07-2022-10332; Author : Baneen Mahmood Habeeb, Anfal Ali Shakir, Alyaa Saad Abed,
Abstract : A 350-kDa protein is encoded by the ataxia telangiectasia mutated gene (ATM), a potential breast cancer risk gene. and is one of the fundamental components of the DNA-damage response system. The current study aimed to determine the function of inhibitory and regulatory gene ATM in the etiology of breast cancer in Iraqi women by identifying radiotherapy's detrimental impact on molecular factors about 10-20 Gy locally gamma cells, which may have an impact on cancer patients' genetic material (DNA). At the Al-Amel National Hospital for Cancer Management in Baghdad, this study was conducted on 18 breast cancer patients from Iraq. over three months eighteen healthy ladies, aged 35 to 45 years, are non-smokers and non-alcoholics. The results of gene expression show a significant difference in the ATM treatment comparison between the initial and final administration of RT. P value= 0.0047. Specialized primer genes were chosen for the mRNA genes ATM, as well as the primers for the internal control (actin) gene. which has a relationship with Ionizing radiation, using RT-PCR to analyze gene expression. According to the findings, radiation activates the ATM gene, which is involved in the cell cycle, DNA repair, and apoptosis regulation.
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EFFICACY OF ABSORBENT DRESSING AND COMBINATION OF PLATELET-RICH PLASMA WITH POYHEXAMETHYLENE BIGUINIDE BETAINE IN WOUND HEALING OF NECROTIZING CELLULITIS: A CASE REPORT
Journal ID : AMJ-31-07-2022-10331; Author : Anita Berliana, Asnawi Madjid, Khaeruddin Djawad, Safruddin Amin,
Abstract : Necrotizing cellulitis is a necrotizing infection with or without gas formation localized to the skin and subcutaneous tissue but does not involve the underlying fascia and muscles. Management should prioritize timely diagnosis and intervention with appropriate management and antibiotics. It is reported that a 67-year-old male patient with necrotizing cellulitis on the left leg with culture results of staphylococcus aureus was given broad-spectrum systemic antibiotic therapy according to the sensitivity results and treated using absorbent dressing in the form of foam and a combination of platelet-rich plasma (PRP) and polyhexamethylene. Biguanide (PHMB) makes granulation tissue appear rapidly and re-epithelializes complete in 8 weeks. Necrotizing cellulitis is an infection with a lot of exudates and necrotic tissue. Excessive wound infection and exudation were treated with systemic antibiotics and absorbent dressings, and the combination of PRP and PHMB can increase the efficacy of therapy by increasing the granulation tissue formation and epithelialization of wound healing. The success of absorbent dressing therapy and the combination of PRP with PHMB can provide satisfactory therapeutic results and can help the process of new tissue formation and complete epithelialization of necrotizing cellulitis ulcers in 8 weeks.
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Purification and Study the Kinetics Properties of Glucose-6-Phosphate Dehydrogenase from Pediatric Patients with Favism Disease
Journal ID : AMJ-31-07-2022-10330; Author : Zahraa Kadhim Mohammed,
Abstract : In Iraq, The glucose-6-phosphate dehydrogenase gene is an x-linked disease, and its deficiency is common throughout the world. This study was conducted to purify Glucose 6-phosphate dehydrogenase from favism patients and determination [Km, Vmax], and study the effect of optimum temperature, substrate, PH for G6pd in patient and control, the ongoing review presumed that the ideal pH of the enzymatic concentrate was in the reach [8-8.4]. the chemical has the most elevated compelling enzymatic at 8.5 pH for patients. The temperature of protein was steady to 37 ºC for patients and apparently exhibited the most elevated at 40 ºC. The constants were; for Michaelis-Menten of substrate [G6P] and the Vmax were [0.42mM] [27.17UI/ml] for patients and [0.142mM] and [79.36UI\ml] for control respectively.
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Differences between vitamin D levels in premature neonates with respiratory Distress and without respiratory distress
Journal ID : AMJ-30-07-2022-10329; Author : Riyan Agus Faisal Hasibuan, Beby Syofiani Hasibuan, Rizky Adriansyah, Juliandi Harahap, Rosmayanti Siregar, Karina Sugih Arto,
Abstract : Respiratory distress is associated with lung maturation and vitamin D which is explained by the mechanism of production and secretion of phospholipids (surfactants) on the surface of type II alveolar cells (ATII). To determine the differences between in vitamin D levels in premature neonates with respiratory distress in premature neonates and without respiratory distress. Analytical analyses with a case-control study in premature neonates who experienced respiratory distress at the H. Adam Malik Medan General Hospital from September 2021 to March 2022. To assess the difference among variables with t-independent test, Mann-Whitney test, and Kruskal Wallis test. A total of 25 patients with respiratory distress samples and 25 controls were analyzed. Differences between the classification of vitamin D levels in children with respiratory distress and without respiratory distress had a significant (p=0.014) with vitamin D level with respiratory distress of 14.72. The difference between Downe Score and APGAR Score in children with respiratory distress and without respiratory distress also had significance (p=0.001) with a mean of Downe Score of 4.68 and APGAR Score of 5.96 for the first 7.16 for the fifth, and 7.6 for the tenth minutes. The differences between Downe Score and vitamin D levels in the group of infants with respiratory distress did not have a significant (p=0.742). There are significant differences among the classification of vitamin D levels, Downe Score and APGAR Score in neonates with respiratory distress and without respiratory distress. However, there was no significant differences between Downe Score and vitamin D levels.
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The Effectiveness of Physical Exercise on Changes in Vo2max, Muscle Endurance, and Blood hemoglobin levels in athletes
Journal ID : AMJ-30-07-2022-10328; Author : Hasnia Ahmad, Aco Tang1, Djohan Aras, Hendrik Hendrik,
Abstract : Athletes' physical fitness, especially VO2max and muscle endurance, must be increased or maintained because it determines the ability of an athlete to carry out their activities. Physical fitness needs special attention because it is an important element in almost all sports. To determine the effect of physical exercise on changes in VO2max, muscle endurance, and hemoglobin in athletes. This research is a quasi-experimental research with a pre and post-test one-group design with two measurements, before exercise, and after exercise. A total of 40 samples were recruited to participate in this study with predetermined inclusion and exclusion criteria. Physical exercise was given 3 times a week for 2 months. VO2max with bleep test, muscle endurance with half squat jump, and Hemoglobin with routine blood test Results. Physical exercise is very effective on athlete's muscle endurance but is not effective for increasing VO2max and hemoglobin of athletes at the Makassar Student Sports Education and Training Center (PPLP).
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