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Azerbaijan Medical Journal

(ISSN: 0005-2523)

Azerbaijan medical journal (ISSN: 0005-2523) - is a scopus indexed journal since 1961. The publisher of the journal is Izdatel'stvo Elm by WHO Office in Azerbaijan. Azerbaijan medical journal (AMJ) is also UGC approved. The journal publishes general medicine, health science, psychological, pharmaceutical journals and so on.

Aim and Scope

Azerbaijan Medical Journal

Azerbaijan Medical Journal (ISSN: 0005-2523) - is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to.

Anatomy Physiology Biochemistry Pharmacology Pathology Forensic medicine Microbiology Community Medicine Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases Anaesthesia Cancer research Neurosurgery Orthopedics Gastroenterology Neurology Nephrology Medical education Orthopaedics Paediatrics Reproduction Cardiology Diabetes Surgery Nursing Otolaryngology Dental Psychology Anesthesiology Dermatology Endocrinology Hepatology Urology Venereology Psychiatry Biotechnology Pharmacy ENT Pharmaceutical Chemistry Pharmaceutical Analysis Pharmaceutics Pulmonology Pharmacognosy Pharmaceutical Phatmaceutical Technology Biopharmaceutics Pharmacokinetics Pharmacodynamics Industrial Pharmacy Drug Design Quality Assurance Drug Regulatory Affairs Phytochemistry Drug Delivery Systems Pharmaceutical Nanotechnology Pharmaceutical Microbiology Hospital Pharmacy Clinical Pharmacy Pharmacy Practice Drug Discovery Drug Metabolism Toxicology Clinical Research Pharmacogenomics Phrmacoinformatics Pharmacovigilance< Life Sciences like Chemistry Biomedical Sciences Microbiology Immunology Forensic Epidemiology Oncology Biomedicine Dentistry Physiotherapy Gynaecology Dermatoepidemiology Neuroscience Ophthalmology Sexology Osteology Kinesiology Angiology/Vascular Medicine Critical care Medicine Haematology Infectious Diseases and Vaccinology Bariatrics Pharmacy and Nursing Pharmacognosy and Phytochemistry Radiobiology Clinical immunology Clinical and Hospital Pharmacy Cell Biology Genomics and Proteomics Healthcare Services Healthcare Management Bioinformatics and Biotechnology Geriatric Medicine

Latest Journals

Azerbaijan Medical Journal

The Effectiveness of Oral and Topical Glutathione on Improving Signs of Skin Aging: A Double-Blind Randomized Controlled Clinical Trial
Journal ID : AMJ-30-07-2022-10327; Author : Siswanto Wahab, Anis Irawan Anwar, Asvina Anis Anwar, Andi Nurhaerani Zainuddin, Ivan Kurniadi, Nuril Ilmi,
Abstract : Glutathione is a well-known potent antioxidant which also possesses skin-lightening and anti-aging properties. Despite its popularity as main ingredients on skin care and supplementation, the anti-aging effect of of oral and topical glutathione combination is unknown. This study aimed to compare the anti-aging effect of oral and topical glutathione combination therapy against monotherapy and placebo. A randomized, double-blind, placebo-controlled clinical trial was conducted on healthy women aged 25-50 years old. The subjects were randomly assigned into one of four intervention groups (I=topical glutathione + oral placebo; II=topical + oral placebo; III=topical + oral glutathione; IV=topical placebo + oral glutathione). The clinical changes on spots, pores, roughness, wrinkles, signs of ultraviolet acnes (UV-A), and ultraviolet spots (UV-S) were assessed biweekly with Janus-II measurement system for a total of 8 weeks. Mann Whitney U test was used to compare the mean difference between each glutathione group (I, III, IV) and placebo group (II). Group IV demonstrated the least increase of spots and significant reduction of pores and roughness compared to placebo (p<0,05). Group I experienced the most reduction in wrinkles and UV spot parameter (p<0,05). Whereas group III shows the biggest improvement on UV acne parameter (p<0,05). The study shows the benefits of topical and/or oral glutathione on defying the skin aging process compared to the placebo. However, the combination of oral and topical glutathione is not as effective as monotherapy, except in UV acne parameter.
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Effectivity of Polidocanol, Ethanol, and Bleomycin as Sclerosing Agent in Vivo
Journal ID : AMJ-29-07-2022-10326; Author : Benny Kurniawan, Muhammad Nuralim Mallapasi, Mulawardi, Jayarasti Kusumanegara, Umar Usman, Firdaus Hamid, M Husni Cangara,
Abstract : This study aims to examine the effectiveness of polidocanol, ethanol and bleomycin as sclerosant agents in the animal model. An experimental study design was performed on 24 Lepus nigricollis rabbits (48 ears) which were divided into three treatment groups: polidocanol (group I, n=16), ethanol (group II, n=16), and bleomycin (group 3, n=16). All animals received treatment by injection into the dorsal vein behind the ear, then damming the vein 10 minutes later. After that, punch tissue samples were taken from blood vessels for 60 minutes, 24 hours, seven days, and 45 days evenly in each group for standard histopathological examination. The severity of histopathology changes was scored by inflammation, proliferation, luminal narrowing and vascular fibrosis. There were no differences in the degree of inflammation, proliferation, luminal narrowing and fibrosis in the three treatment groups with different sclerosing agents and at different times. There was a positive and significant correlation to vascular proliferation, luminal narrowing, and fibrosis over measurement time (all p<0.005). There was a positive and significant correlation to luminal narrowing and fibrosis over measurement time (all p<0.005). There was a positive and significant correlation to inflammation, luminal narrowing, and fibrosis over measurement time (all p<0.005). In conclusion, bleomycin, polidocanol, and ethanol have a similar effectivity as a sclerosing agent in vivo. However, almost histopathology changes significantly correlate with bleomycin, polidocanol, and ethanol over time.
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Quality of Life Factors Associated with Diabetes Mellitus in Patients with Pre-Ulcers: Cross Sectional Study in Takalar Regency
Journal ID : AMJ-29-07-2022-10325; Author : Suardi Suardi, Amran Razak, Ridwan Amiruddind,, Hasanuddin Ishak, Ummu Salmah, Ida Leida Maria, Nursalam Nursalam, Saldy Yusuf,
Abstract : Diabetes mellitus (DM) is a chronic metabolic disease, of which its prevalence remains increased worldwide. So far, the focus of research in several countries is only on DM patients who have experienced diabetic foot ulcers without paying attention or seeing the condition of pre-ulcerss. If pre-ulcers can be controlled from the start, it will improve the condition of DM patients so that the quality of life will also be better. This study aimed to examine factors associated with the quality of life in diabetic patients with pre- ulcers condition. This study was cross-sectional conducted in Takalar regency, Indonesia. Data collection using Questionnaire WHOQOL-BREF is a summary of the World Health Organization Quality Of Life (WHOQOL) which consists of 26 questions. A total of 33 respondents were selected using an accidental sampling method. Data analysis was carried out using the chi-square test with a significant degree of p<0.05. The results showed a relationship between occupational status and the quality of life (ρ=0.049). Similarly, there was a significant association of environment (ρ=0.033) and service quality (ρ=0.017) with the quality of life. There is a relationship between work, environment, and quality of service with quality of life in patients with diabetes mellitus with pre-ulcers in Takalar regency.
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Protective effect of Sweet potato (Ipomoea batatas L.) and Carrot (Daucus carota L.) juices against gastric ulcer induced experimentally
Journal ID : AMJ-29-07-2022-10324; Author : Dina H. Sayed, Amal H. Hamza, Hanan M. F.Abd El-Wahab, Sahar M.Galal, Amina A.S. Abdel Rahman, Fatma H.Abd El-Razik,
Abstract : Gastric ulcer (GU) is a serious gastrointestinal disease, poses a considerable threat to humans, It’s pathophysiology involves an imbalance between mucosal protective and offensive factors. This study highlighted the protective effect of either sweet potato juice (SPJ) carrot juice (CJ) or their combination against gastric ulcer induced by indomethacin. Sixty male adult albino rats Sprague-Dawley strain were equally divided into six groups, group (1) healthy control group, group (2) GU group, group (3) SPJ + GU, group (4) CJ + GU, group (5) mixture of SPJ& CJ (MJ)+ GU, group (6) Omperazole (Omp) + GU. Biochemical investigations include oxidative stress (MDA and NO), antioxidant (SOD, GSH and TAC), inflammatory (IL-6, TNF-α and CRP) and apoptotic biomarker Caspase-3. Also, PGE2, COX-1, pepsin and hydroxyproline. Furthermore, gastric juice was examined for pH, while gastric tissues were examined for ulcer score, ulcer index as well as gene expression level of Hsp70. Histopathology observation of gastric tissues was detected by hematoxylin and eosin (H&E) staining, the expression of Bcl-2 and Bax in gastric tissues were evaluated by immunohistochemistry (IHC). Results obtained from the current study revealed that either SPJ, CJ or the MJ exert a protective effect against GU, shown by a decrease in the gastric ulcer index and score as well as the biochemical parameters in serum. The juices up-regulate the expression of HSP-70 and by up-regulation of Bcl-2 and down-regulation of Bax. SPJ and CJ are therapeutically valuable for enhancing gastric ulcer remediation as they are capable of inhibiting indomethacin-induced damage.
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The Effectiveness of Dequalinium Chloride Compared to Metronidazole as a Therapy for Bacterial Vaginosis
Journal ID : AMJ-29-07-2022-10323; Author : Junita Indarti, Reyhan Aditya, Omo Abdul Madjid,
Abstract : Centers for Disease Control and Prevention (CDC) recommends antibiotics metronidazole and clindamycin as the first-line therapy for bacterial vaginosis. It correlates with the number of antibiotic resistances. Therefore, an alternative to antibiotic, such as antiseptic, is sought to deal with these problems. Dequalinium chloride (DQC) is one of the antiseptics that has been widely studied as a therapy for bacterial vaginosis. The broad spectrum activity of DQC increases its effectiveness against bacterial vaginosis. This double-blind randomized controlled trial was carried out at Dr. Cipto Mangunkusumo General Hospital from November 2020 – October 2021. The effectiveness of Dequalinium chloride was compared with Metronidazole as control (17 subjects for each group). The randomization was performed using block randomization. The outcome that was reported in this study was the cure rate as well as the side effects experienced by the users. The cure rate of subjects in treatment (DQC treatment) group was 94.12%; as compared to 100% in control groups. The difference in cure rate was not statistically significant (p = 0.50). No subjects reported any side effects in both groups. Dequalinium chloride is a safe and effective alternative to Metronidazole in treating bacterial vaginosis.
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Breast Mass Among Young and Adolescent Attending Al-Elwiya Teaching Hospital
Journal ID : AMJ-29-07-2022-10321; Author : KHANSAA HUSSEIN ALI, BASMA MOHAMMED ALI IBRAHIM, NAJIM ABID ISSA,
Abstract : The purpose of this study was to evaluate the incidence and clinical manifestations of benign breast lumps in adolescents admitted to a Al-Elwiya Teaching Hospital. All adolescents who visited the outpatient department (OPD) with breast lump complaints were enrolled in the study. Patients were a one hundred cases with breast lump with age of 25 years or less. All patients had assessment in the form of short history, clinical examination, ultrasound examination and fine needle aspiration cytology (FNA). As fibroadenoma found in 10% of all women according to the Autopsy studies. Regarding body mass index, no statistical difference was found. According to the occupation and educational level, no difference in the diagnosis was found. Marital status had no difference on the diagnosis of breast mass. Nulliparity (together with gravidity, parity and miscarriage) were associated with high rate of fibroadenoma. The side of the breast mass, past surgical history, past medical history, smoking all were not different in regard to the diagnosis of breast mass. Although, both family history and 1st and 2nd degree relatives with benign breast disease were not significant different in regard to the diagnosis of breast mass; all cases of positive family history of fibroadenoma had the similar diagnosis in both 1st and 2nd degree relatives. Most common cause of benign breast mass is fibroadenoma. Fibroadenoma was more common in age group ranged from 15-21 years, cases of nulliparity, positive family history and hormonal treatment.
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Changes in sitting height ratio of Yogyakarta children aged 7-15 years
Journal ID : AMJ-29-07-2022-10320; Author : Margaretha Ivana Bintoro, Neni Trilusiana Rahmawati, Janatin Hastuti, Zaenal Muttaqien,
Abstract : Poor health status, unhealthy behavior, nutritional status, and lifestyle can cause disproportionate growth, and body proportions can be seen from the sitting height ratio. This study aimed to evaluate the changes of sitting height ratio of Yogyakarta boys and girls aged 7-15 years. A cross sectional data was performed on 492 Javanese children consisting of 237 boys and 255 girls, aged 6-12 years. The body height and sitting height of each subject was measured in order to calculate the ratio between sitting height and height. Anthropometric measurements were measured to all subjects based on the International Standard for Anthropometric Assessment procedures. Data were analyzed using ANOVA, Chi-Square tests, and simple linear regression analysis with a significance of p<0.05. There were significant differences between the average sitting height and sitting height ratio between boys and girls. Average height and sitting height of boys was 140.18 cm and 71.93 cm, while girls were 142.58 cm and 74.25 cm, respectively. There was a positive correlation (p<0.05) between sitting height, height, and sitting height ratio with age in both sexes. Among children the older the age, the greater the sitting height ratio. Sitting height ratio can be used to assist in the diagnosis and follow-up of children with growth problems.
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¬Comparison of sperm parameters improvement and complications between retroperitoneal and microsurgical varicocelectomy
Journal ID : AMJ-29-07-2022-10319; Author : Gede Wirya Kusuma Duarsa, Prisca Oriana Sutanto, Kadek Budi Santosa, I Wayan Yudiana, Pande Made Wisnu Tirtayasa, Ida Bagus Putra Pramana, Anak Agung Gde Oka, Tjokorda Gde Bagus Mahadewa, Adinda Putra Pradhana,
Abstract : Varicocele is one of the causes of male infertility that can be corrected surgically. There are several varicocelectomy surgical techniques, including retroperitoneal technique and microsurgical technique. This study aims to compare the sperm parameters improvement and complications between retroperitoneal and microsurgical techniques. This study is a prospective cohort study. Data were taken from the medical records of patients who underwent varicocelectomy surgery from January 2016 to February 2019. A total of 100 patients, with grade 2-3 varicocele, divided evenly into retroperitoneal technique group, and microsurgical technique group. The same surgeon performed the operations. The sperm parameters before and after surgery, postoperative hydrocele, and the degree of postoperative pain were evaluated. There was a significant improvement in postoperative sperm parameters in both techniques. Whereas the results of postoperative sperm parameters between both techniques didn’t show a significant difference. No postoperative hydrocele was found in both techniques. A mild degree of postoperative pain was found in all study subjects in the microsurgical group. Whereas in the retroperitoneal group, mild postoperative pain was found in 11 subjects, and moderate postoperative pain was found in 39 subjects. Varicocelectomy provides a significant improvement in the postoperative sperm parameters. Both techniques provide equal significant improvement in sperm parameters with fewer hydrocele complication events. The microsurgical technique provides a better degree of postoperative pain than retroperitoneal techniques.
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Effect of metformin on gamma radiation -Induced DNA oxidation damage in Human Peripheral Blood Lymphocytes in vitro.
Journal ID : AMJ-28-07-2022-10318; Author : Ali Niama Salman, Farha Abd Ali Shafi, Abdual Sahib Kadhim Al-Zayadi,
Abstract : The aim of the study was to assess the effect of metformin (an anti-hyperglycemic drug in type 2 diabetes (T2D) patient) on DNA oxidative damage in vitro in human peripheral blood lymphocyte from 10 donors; evaluation of the oxidative damage induced by 1 and 2 Gy gamma rays; and assessed the role of metformin in protecting lymphocytes against the oxidative damage induced by gamma rays. The 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit was used to detect the DNA oxidative damage in blood lymphocytes. Metformin (10 and 50µM) in vitro increased the rate of (8-OHdG) significantly (P ≤ 0.001) than control samples value. Irradiated blood lymphocyte with 1 Gy gamma rays elevated the DNA oxidative damage in rate (95%) and significantly (P ≤ 0.001) than control values, and the rise of irradiation into 2 Gy, caused increase the DNA oxidative damage (8-OHdG) 2.3 folds and significantly (P ≤ 0.001) than 1 Gy irradiated. Blood treated with metformin prior irradiation enhance the reduction of (8-OHdG) specially in blood irradiated by 2 Gy gamma ray, the reduction significantly (P ≤ 0.05 and P ≤ 0.001) respectively for (10 and 50 µM) metformin treated compared with irradiated group only.
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Foundational Competencies of PHNs in Dealing with Disaster Recovery Phase: An Integrative Review
Journal ID : AMJ-28-07-2022-10317; Author : Ardia Putra,
Abstract : Disasters have continued worldwide, and these events constitute an essential concern for nurses in pursuing a strategic map to address this issue. As a discipline that plays a fundamental role in delivering disaster care, PHNs will be part of the discipline and are expected to participate actively in disaster management programs. This review paper investigates the foundational competencies of PHNs in dealing with the disaster recovery phase. An integrative review approach is achieved with various sources of information from an intensive search of the related literature by multiple methods. In developing the foundational competencies of PHNs in this study, nurses' knowledge, skills, and competencies in the disaster recovery stage launched by the organization's review papers and research papers will be discussed. Literature was searched by using a keyword combination as follows: "disaster mitigation" or "disaster preparedness" or "disaster-prone population," and "disaster recovery phase" and "the role of nurses" or "community disaster nursing. The main focus on PHNs competencies at this stage is assessing public health impacts and health promotion for the community. To participate actively during this period, they must possess knowledge and expertise in disaster management to work effectively in the event of a disaster. Moreover, intensive and sustained health promotion must be improved to raise awareness of potential risks to their quality of life following a disaster or catastrophe.
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