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30 Jun 2023

Azerbaijan Medical Journal

(ISSN: 0005-2523)

Azerbaijan medical journal (ISSN: 0005-2523) - is a scopus indexed journal since 1961. The publisher of the journal is Izdatel'stvo Elm by WHO Office in Azerbaijan. Azerbaijan medical journal (AMJ) is also UGC approved. The journal publishes general medicine, health science, psychological, pharmaceutical journals and so on. Gongcheng Kexue Yu Jishu/Advanced Engineering Science Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery Tobacco Science and Technology Zhenkong Kexue yu Jishu Xuebao/Journal of Vacuum Science and Technology Kongzhi yu Juece/Control and Decision Changjiang Liuyu Ziyuan Yu Huanjing/Resources and Environment in the Yangtze Valley

Aim and Scope

Azerbaijan Medical Journal

Azerbaijan Medical Journal (ISSN: 0005-2523) - is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to. Zhongguo Shiyou Daxue Xuebao (Ziran Kexue Ban)/Journal of China University of Petroleum (Edition of Natural Science) Teikyo Medical Journal Wuhan Ligong Daxue Xuebao (Jiaotong Kexue Yu Gongcheng Ban)/Journal of Wuhan University of Technology (Transportation Science and Engineering) Zhonghua yi shi za zhi (Beijing, China : 1980) Agricultural Mechanization in Asia, Africa and Latin America International Medical Journal Technology Reports of Kansai University Asia Life Sciences Open Access Journals Tagliche Praxis

Anatomy Physiology Biochemistry Pharmacology Pathology Forensic medicine Microbiology Community Medicine Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases Anaesthesia Cancer research Neurosurgery Orthopedics Gastroenterology Neurology Nephrology Medical education Orthopaedics Paediatrics Reproduction Cardiology Diabetes Surgery Nursing Otolaryngology Dental Psychology Anesthesiology Dermatology Endocrinology Hepatology Urology Venereology Psychiatry Biotechnology Pharmacy ENT Pharmaceutical Chemistry Pharmaceutical Analysis Pharmaceutics Pulmonology Pharmacognosy Pharmaceutical Phatmaceutical Technology Biopharmaceutics Pharmacokinetics Pharmacodynamics Industrial Pharmacy Drug Design Quality Assurance Drug Regulatory Affairs Phytochemistry Drug Delivery Systems Pharmaceutical Nanotechnology Pharmaceutical Microbiology Hospital Pharmacy Clinical Pharmacy Pharmacy Practice Drug Discovery Drug Metabolism Toxicology Clinical Research Pharmacogenomics Phrmacoinformatics Pharmacovigilance< Life Sciences like Chemistry Biomedical Sciences Microbiology Immunology Forensic Epidemiology Oncology Biomedicine Dentistry Physiotherapy Gynaecology Dermatoepidemiology Neuroscience Ophthalmology Sexology Osteology Kinesiology Angiology/Vascular Medicine Critical care Medicine Haematology Infectious Diseases and Vaccinology Bariatrics Pharmacy and Nursing Pharmacognosy and Phytochemistry Radiobiology Clinical immunology Clinical and Hospital Pharmacy Cell Biology Genomics and Proteomics Healthcare Services Healthcare Management Bioinformatics and Biotechnology Geriatric Medicine Bulletin of National Institute of Health Sciences Journal of the Austrian Society of Agricultural Economics Gongcheng Kexue Yu Jishu/Advanced Engineering Science Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery Tobacco Science and Technology Zhenkong Kexue yu Jishu Xuebao/Journal of Vacuum Science and Technology Wuhan Ligong Daxue Xuebao (Jiaotong Kexue Yu Gongcheng Ban)/Journal of Wuhan University of Technology (Transportation Science and Engineering) Zhonghua yi shi za zhi (Beijing, China : 1980) Zhongguo Shiyou Daxue Xuebao (Ziran Kexue Ban)/Journal of China University of Petroleum (Edition of Natural Science) Teikyo Medical Journal Kongzhi yu Juece/Control and Decision Changjiang Liuyu Ziyuan Yu Huanjing/Resources and Environment in the Yangtze Valley

Latest Journals

Azerbaijan Medical Journal

Agricultural Mechanization in Asia, Africa and Latin America International Medical Journal Technology Reports of Kansai University Asia Life Sciences Open Access Journals Tagliche Praxis Bulletin of National Institute of Health Sciences Journal of the Austrian Society of Agricultural Economics
The Potent of Radical Scavenging, Toxicity, and Apoptosis of Various Fractions of Marine Sponge Axinella aruensis from Kangean Islands
Journal ID : AMJ-16-11-2022-10797; Author : Mohammad Farid Rahman, Aulanni’am, Masruri, Akhmad Sabarudin, Siti Mariyah Ulfa, Edwin Setiawan,
Abstract : A sponge of the family Axinellidae is a marine invertebrate with plenty of medical potential applications. The present study aimed to investigate the antioxidative, toxicity, and apoptotic effects of Axinella aruensis extracts and fractions, particularly from the Indonesian Kangean Islands. The sponge was extracted with methanol, then partitioned with hexane, ethyl acetate, butanol, and water. Each fraction was observed for its free radical scavenging properties to DPPH, toxicity, and apoptosis to HeLa and MCF-7 cell lines. Experimental results show that the ethyl acetate fraction provides the highest activity than the methanolic extract and other fractions. The ethyl acetate fraction gives a strong DPPH radical scavenging with an IC50 value of 27.724 ± 0.029 g/mL and is toxic to Artemia salina with an LC50 value of 24.711 ± 0.478 g/mL. Cytotoxic activity of ethyl acetate fraction against HeLa and MCF-7 cells provide IC50 values of 89.990 ± 2.133 g/mL and 94.143 ± 0.720 g/mL, and induced apoptosis in both cells with IC50 values of 96.659 ± 0.023 g/mL and 93.474 ± 0.013 g/mL. The butanol fraction also showed intense activity, which was relatively comparable to the methanolic extract, although both activities were lower than that of the ethyl acetate fraction. Based on the metabolites fingerprinting analysis results, the ethyl acetate fraction consists of brominated compounds suspected of strongly influencing its anti-cancer properties. The sponge A. aruensis is undergoing further analysis to isolate and characterize the active constituents in each fraction, and thus can be developed for potential anticancer treatment.
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Mesenchymal Stem Cell (MSC) Metabolite as a Potential Cell Therapy for Pseudomonas aeruginosa Keratitis
Journal ID : AMJ-16-11-2022-10796; Author : Dimas Budiharto, Ismi Zuhria, Nurwasis,
Abstract : Pseudomonas aeruginosa keratitis is the most common eye infection, that develops very rapidly and can lead to endophthalmitis and corneal perforation. Corneal wound healing process is determined by the balance of pro-inflammatory and anti-inflammatory cytokines. Interleukin-1 alpha (IL-1α) and Transforming Growth Factor-β (TGF-β) as “master regulator” cytokines. Mesenchymal stem cells can maintain the equilibrium of these two inflammatory cytokines. The study was to analyze the effect of MSC metabolite to the expression of IL-1α and TGF-β. This study was an animal experimental study. The mice were randomly divided into 3 groups (no treatment, antibiotic and antibiotic-MSC metabolite group). Each group consisted of 6 mice. Keratitis was induced by 5 µl Pseudomonas aeruginosa suspension containing 104 CFU/ml. Isolation of limbus mesenchymal stem cells and cell culture were conducted. The Immunoreactive Score (IRS) and immunohistochemical staining were used to assess IL-1α and TGF- β expression. The mean expression of IL-1α in the antibiotic group with Immunoreactive Score (IRS) was 5.03 ± 3.03, while in the antibiotic + MSC metabolite group it was 4.5 ± 2.51. TGF-β expression in the antibiotic group obtained a mean score of 4.26 ± 2.31, while in the combination group of antibiotics and MSC metabolites the mean score was 2.8 ± 1.30. There was a decrease of the IL-1α and TGF- β expression in the group that was added to the MSC metabolite. The Independent T-Test showed that there was no significant difference between the antibiotic group and the antibiotic + MSC metabolite group p>0.05 (p=0.673 in IL-1α and p = 0.143 in TGF-β expression). Mesenchymal stem cell (MSC) metabolite is a potential cell therapy for corneal wound healing of Pseudomonas aeruginosa keratitis, but further studies are still needed with more sample.
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THYROID GLAND INCIDENTALOMAS FINDINGS IN A SAMPLE OF IRAQI NECROPSIES
Journal ID : AMJ-15-11-2022-10792; Author : Mohammad Abdulmohsin Jebur,
Abstract : Glandula thyreoidea (Thyroid gland), incidentalomas in the community are common, mostly in females and old peoples. In most instances the finding of nodularity is accidental and insignificant because only part of them is of abnormal outgrowth. In spite of negligible chance of abnormality, it is important to isolate and discriminate this probability. The purpose of this study is to discover the presence of nodularity in a randomized sample of causalities referred to the Medico-Legal Directorate at Baghdad, associated with many features in the community such as age, gender, race. etc, and the samples were examined by gross and microscopic analyses respectively. Specimens were gathered from 50 necropsies in the Medico-Legal Directorate at Baghdad. The specimens were underwent routine histopathological approach. The study declared that 50% of the samples with nodularity findings were dormant in the patients' lives without diagnosis, with predominance in the women 14 (66.66%) with average age 65 years compared with men 11 (37.93%) and average age 60 years. Three (12%) of the samples showed carcinomatous features.
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ANTIOXIDANT POTENTIAL AND TOTAL PHENOLIC OF ETHANOL EXTRACT BELIGO (Benincasa hispida (Thunb.) Cogn.) SEEDS
Journal ID : AMJ-15-11-2022-10791; Author : Haerani Rasyid, Agussalim Bukhari, Nur Alim, Natsir Djide, Sartini, Rusman Hasanuddin,
Abstract : The use of plants as a source of natural antioxidants has been widely studied. One of the plants that have the potential as natural antioxidants is beligo (Benincasa hispida (Thunb.) Cogn.). The part of the beligo fruit that is commonly used is the seeds. Empirically beligo has been widely used by Indonesian people as a medicinal plant. Indonesian people use beligo as a fever reducer, pain and typhoid treatment, presumably based on its phenolic content. Phenolics have a role in antioxidant activity. Ethanol 70% is a solvent that has been proven to be widely used to extract total plant phenolic compounds. This study aims to determine the phytochemical content, phenolic content and antioxidant potential of ethanol 70% extract of beligo (Benincasa hispida (Thunb.) Cogn.) seeds. Samples were extracted by maceration using ethanol 70%. Qualitative analysis of phytochemical compounds using specific reagents, analysis of total phenolic content using the Folin–Ciocalteu method at a wavelength of 764 and an antioxidant activity test using the DPPH method at a wavelength of 515 nm. Ethanol extract of Beligo (Benincasa hispida (Thunb.) Cogn. seeds positive contains alkaloids, flavonoids, phenolics and saponins. The results of the analysis of total phenolic content and antioxidant activity test showed that ethanol 70% extract had a total phenolic content of 56.8 mg GAE/g extract with an IC50 value of 46,037 ppm. Ethanol 70% extract has a very strong category of antioxidant activity so it has the potential to be used in the treatment of antibacterial, cardiovascular and anti-inflammatory diseases.
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Macrophage Phagocytic Activity and Capacity in Male White Rats Demonstrates the Immunomodulatory Activity of 70% Ethanol Extract of Arabic Jujube Leaves (Ziziphus Spina-Christi L.)
Journal ID : AMJ-15-11-2022-10790; Author : Novi Yantih, Sarah Zaidan, Elvira Andini, Desi Nadya Aulena, Kartiningsih,
Abstract : Arabic jujube leaves (Ziziphus spina-christi L.) contain various bioactive compounds and dichloromethane extract from the roots exhibits immunomodulatory activity. This study aims to determine the activity of a 70% ethanol extract of Arabic jujube leaves as an immunomodulator in male white rats based on macrophage phagocytic activity and capacity. Arabic jujube leaves were macerated for 24 hours. Rats were divided into 6 treatment groups. Each group consisted of 4 rats. Group I was administered water as a normal control, Group II was given Na-CMC as a negative control, and Group III was administered 2.7 mg/0.54 mL Phyllanthus niruri L. (P. niruri) product as a positive control, and Groups IV-VI were given 70% ethanol extract of Arabic jujube leaves at doses of 100, 200, and 400 mg/kg BW. On the 8th day, Groups II - VI were infected with Staphylococcus aureus. The average values of macrophage phagocytic activity in mice treated with the 70% ethanol extract of Arabic jujube leaves at doses of 100, 200, and 400 mg/kg BW were 65.25%, 73.50%, and 79.75%, respectively, whereas the macrophage phagocytic capacities were 448.5, 479.0, and 537.3, respectively. The higher the dose of extract, the higher the macrophage phagocytic activity and capacity, which indicates greater immunomodulatory activity. ANOVA showed that the macrophage phagocytic activity and capacity significantly differed among Groups I-VI. Data analysis using Duncan’s test showed that the phagocytic activity in Group III (positive control) was not significantly different from Group IV (treated with 400 mg/kg BW 70% ethanol extract of Arabic jujube leaves), whereas the phagocytic capacity of macrophages in the peritoneum of rats in the test groups significantly differed from the positive control group. Based on these results, it can be concluded that the 70% ethanol extract of Arabic jujube leaves has immunomodulatory activity in rats. The phagocytic activity of the 70% ethanol extract of Arabic jujube leaves at a dose of 400 mg/kg BW was not significantly different from that of the P. niruri product at a dose of 2.7 mg/0.54 mL, but its phagocytic capacity was slightly reduced.
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FACTOR CONTRIBUTING TO INCIDENCE OF PLANTAR FASCIOPATHY BY ASSESSING PLANTAR FASCIA THICKNESS ULTRASOUND MEASUREMENT
Journal ID : AMJ-15-11-2022-10789; Author : Yusak Mangara Tua Siahaan, Vinson hartoyo, Veli Sunggono,
Abstract : Plantar fasciopathy has become one of the most common underdiagnosed and undertreated heel pain. Many studies have been done to investigate predisposing factors for this disorder, but some of them contradicting. This may be attributed to the employment of physical examination as the sole diagnostic method, which is prone to bias. To investigate predisposing factor of plantar fasciopathy using ultrasound measurement. Cross-sectional study was conducted on patients with complaints of heel pain. They were assessed through physical examination and thickness of fascia plantar confirmed via ultrasound. Fascial thickness, demographic and risk factors data were all documented. A total of 106 patients with a mean age of 52.91±9.08 were employed. Bivariate analysis showed that age is the only significant risk factor (p=0.0017). ROC analysis indicated an AUROC value of 0.7097 (95% CI; 0.596-0.823). LR+ calculation 50 years old age cutoff showed a 62.5% higher risk value. Older age is associated with an increased risk of plantar fasciopathy and should be considered in patients with heel pain complaints. Ultrasound-measured fascia plantar is an objective, easy-to-do, more readily available, and cost-effective method to help diagnose plantar fasciopathy.
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Characteristic of Self-Harm Behaviour among Psychiatric Patients Visiting Outpatients Prof. HB Saanin Mental Hospital in Padang, Indonesia
Journal ID : AMJ-15-11-2022-10788; Author : Mutiara Anissa, Anita Darmayanti, Dessy Abdulla,
Abstract : Self-harm is a person's behavior who intentionally injures his body in various ways without any suicidal intent. Self-harm behavior can include slicing the skin with a razor or other sharp object, burning the body, hitting oneself, picking at scars, pulling hair, and consuming toxic substances. People with self-harm behavior are at high risk of committing suicide. Self-harm behavior is an attempt to escape from emotional pain. The purpose of the study was to determine characteristic of self-harm behaviour among psychiatric patients visiting outpatients Prof. HB Saanin Mental Hospital in Padang, Indonesia. The research used a descriptive study with a cross-sectional approach. The research instrument is Self-Harm Inventory (SHI), using a sample of 104 respondents with a consecutive sampling technique. The results showed that most respondents were in the age range of 36-45 years (35.6%), male (55.8%), single (49%) and homemakers (28.8%). More than half of patients had senior high school education (54.8%) and diagnosed with schizophrenia (67.3%). Most respondents are in the category of mild self-harm (78.8%), and the most self-harm behavior method is thoughts of attacking oneself. The study concludes that patients in the clinical population (with mental disorders) have self-harm behavior.
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Enzybiotics Activity of Phage Endolysin for Treatment of Multi-Drugs Resistant Escherichia coli UTI: in vitro and in vivo study
Journal ID : AMJ-14-11-2022-10785; Author : Haider N. Saqi,
Abstract : Resistant infection with multidrug-resistant Escherichia coli (E. coli) is one of the most common causative agents of bacterial infections and emergence as a multidrug resistant bacterium is a major public health threat worldwide and representing a real problem for health care providers. The use of Bacteriophage lytic enzymes (lysins) are highly evolved molecules that have been specifically developed by phages to quickly and efficiently allow their progeny to be released from the host bacterium while destructing that bacterium. This study aimed for isolation of endolysin from E. coli bacteriophages, and administering them systemic in vivo lab animal and measure the therapeutic efficacy, as well as evaluation of their biosafety for treatment of multi-drugs resistant Escherichia coli in urinary tract infection. This study was performed from September 2019 to February 2020, up to 30 bacteriological samples of uropathogenic Escherichia coli were collected, and examined with their anti-biogram, then bacteriophage cocktails were prepared for three resistant strains of them. Endolysins were extracted from their corresponding bacteriophages, they were characterized; the enzymatic and antibacterial activities of extracted endolysins were tested by in vitro assays; in addition, in vivo experiment was carried out on rabbit animals regarding the therapeutic effect of these extracted endolysins on UTI-causing E. coli. This study showed that the extracted endolysin from highly lytic coliphages were successful in reducing bacterial count in urine of treated rabbit animals which received specific endolysin via venous catheter. Endolysin can be extracted directly from their bacteriophages and being purified and used. The injection of rabbits with UTI with the proper dose of the extracted endolysin was effective in eradicating UTI in all of the treated animals.
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Literature Review: Telemedicine in Chronic Kidney Disease Patients
Journal ID : AMJ-14-11-2022-10783; Author : Nurhidayati, Merita Arini,
Abstract : Telemedicine is a necessity in health services for CKD patients amid technological advances so that health services can reach a wider community and remote places. There are several forms of telemedicine services in CKD patients with inhibiting factors, supporting factors and keys to success in their implementation. The purpose of this study is to determine the form of telemedicine services in CKD patients, find out the factors that are obstacles, supporters and keys to the success of a telemedicine service. Method with literature review discussing telemedicine services in CKD patients through SAGE Journal, Pubmed, BMJ Journal, Plos, JMIR with the keyword’s telemedicine, telehealth, e health on CKD patient. The results obtained by 36 journals selected based on exclusion criteria were finally taken 18 articles for review. Telemedicine services in CKD patients can be preventive, promotive, self-management, diagnostic and treatment services that are connected to an instrument between health workers and patients to achieve the desired health goals. The inhibiting factors, supporting factors and keys to the success of telemedicine services in CKD patients are centered on patients, health workers and technologists who will be bound to each other by an equal need in CKD patients.
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Comparison study of Circulating Adiponectin level in rheumatoid arthritis patients between Etanercept and Rituximab and their correlation with disease activity
Journal ID : AMJ-13-11-2022-10781; Author : Shatha Sabah Shyaa,
Abstract : Adiponectin considered the most abundant adipokine in the body, is a prime example. The development of RA causes the irreversible joint deformity, disability, and a decrease in quality of life. The study aimed to investigate the role of Adiponectin in rheumatoid arthritis patients under biological treatment (ETN, and RTX) and their correlation with Disease activity. During December 2021 and May 2022, case-control research was conducted. The current study included 100 RA patients from Iraq who had registered consultations with rheumatologists. The American-European Consensus Group classification criteria for RA diagnosis and patients were chosen to receive ETN and RTX by the most recent recommendations, and 50 healthy control group. ELISA was used to assess anti-CCP abs and serum adiponectin in RA patients and control groups. In the comparison, the level of Adiponectin in the serum of RA patients under DMARDs was significantly higher (p<0.001) than in the control group. The correlation between auto-antibody (anti-ccp) and adiponectin was a highly significant (r = 〖.533〗^(**)). There is a highly significant correlation between moderate and high CDAI, p-value <0.001. In addition to There are an association of adiponectin with biological treatment (OR = 1.003, p-value = .001, 95% CI = 1.002- 1.005). The sensitivity and specificity of adiponectin were (1.0, 0.80) respectively by ROC curve with cut of point (400,603) pg/gm. The current study concluded high levels of circulating Adiponectin in RA patients have been linked to increased disease activity and disability. Despite continuing to receive Etanercept and Rituximab treatment, there was a positive correlation between the serum levels of adiponectin and the specific diagnostic autoantibody Anti-CCP abs level in patients with rheumatoid arthritis. As a result, it has been hypothesized that this adipokine may have pro-inflammatory effects in rheumatoid arthritis.
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