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Azerbaijan Medical Journal

(ISSN: 0005-2523)

Azerbaijan medical journal (ISSN: 0005-2523) - is a scopus indexed journal since 1961. The publisher of the journal is Izdatel'stvo Elm by WHO Office in Azerbaijan. Azerbaijan medical journal (AMJ) is also UGC approved. The journal publishes general medicine, health science, psychological, pharmaceutical journals and so on.

Aim and Scope

Azerbaijan Medical Journal

Azerbaijan Medical Journal (ISSN: 0005-2523) - is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to.

Anatomy Physiology Biochemistry Pharmacology Pathology Forensic medicine Microbiology Community Medicine Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases Anaesthesia Cancer research Neurosurgery Orthopedics Gastroenterology Neurology Nephrology Medical education Orthopaedics Paediatrics Reproduction Cardiology Diabetes Surgery Nursing Otolaryngology Dental Psychology Anesthesiology Dermatology Endocrinology Hepatology Urology Venereology Psychiatry Biotechnology Pharmacy ENT Pharmaceutical Chemistry Pharmaceutical Analysis Pharmaceutics Pulmonology Pharmacognosy Pharmaceutical Phatmaceutical Technology Biopharmaceutics Pharmacokinetics Pharmacodynamics Industrial Pharmacy Drug Design Quality Assurance Drug Regulatory Affairs Phytochemistry Drug Delivery Systems Pharmaceutical Nanotechnology Pharmaceutical Microbiology Hospital Pharmacy Clinical Pharmacy Pharmacy Practice Drug Discovery Drug Metabolism Toxicology Clinical Research Pharmacogenomics Phrmacoinformatics Pharmacovigilance< Life Sciences like Chemistry Biomedical Sciences Microbiology Immunology Forensic Epidemiology Oncology Biomedicine Dentistry Physiotherapy Gynaecology Dermatoepidemiology Neuroscience Ophthalmology Sexology Osteology Kinesiology Angiology/Vascular Medicine Critical care Medicine Haematology Infectious Diseases and Vaccinology Bariatrics Pharmacy and Nursing Pharmacognosy and Phytochemistry Radiobiology Clinical immunology Clinical and Hospital Pharmacy Cell Biology Genomics and Proteomics Healthcare Services Healthcare Management Bioinformatics and Biotechnology Geriatric Medicine

Latest Journals

Azerbaijan Medical Journal

Histopathological Correlation of ABO Blood Type Antigen Expression in Rectum Tissue in Rectal Adenocarcinoma Patients
Journal ID : AMJ-31-07-2022-10334; Author : Albertus Aryo Pradito, Ihwan Kusuma, M. Husni Cangara, Joko Hendarto, Muh Rusdan Jalil,
Abstract : Early detection is essential to reduce cancer mortality worldwide, including rectal cancer. One factor positively correlated with the incidence of rectal adenocarcinoma is the ABO blood group antigen. However, the use of the ABO antigen as a biomarker in colon cancer screening has not been widely studied. This study aimed to analyze the relationship between the expression of ABO blood group antigens in patients with rectal adenocarcinoma based on the immunohistochemical method. The research was conducted using a cross-sectional study method. The expression of ABO blood group antigens in rectal tissue of the patients with rectal adenocarcinoma was analyzed using the immunohistochemical method (streptavidin-biotin-peroxidase method). Rectal tissue was used as a control without tumor (normal rectal tissue). Statistical data analysis used gamma & Somers correlation and Wilcoxon comparison test. There was a significant difference in the expression of ABO blood group antigens in the rectal tissue between the tumor patient group and the control group (p-value = 0.004). There was no significant correlation between gender, age, stage of adenocarcinoma, histopathological degree of adenocarcinoma, and ABO blood group with the degree of antigen expression of tissue ABO blood group. These results were seen in both the control and tumor group (all p values > 0.05). In conclusion, the expression of the ABO blood group antigen in rectal tissue does not correlate with the tumor stage. However, this antigen can potentially be used as a marker of a malignant process.
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The Role of ATM gene in Iraqi Breast Cancer Patients Undergoing Radiotherapy
Journal ID : AMJ-31-07-2022-10332; Author : Baneen Mahmood Habeeb, Anfal Ali Shakir, Alyaa Saad Abed,
Abstract : A 350-kDa protein is encoded by the ataxia telangiectasia mutated gene (ATM), a potential breast cancer risk gene. and is one of the fundamental components of the DNA-damage response system. The current study aimed to determine the function of inhibitory and regulatory gene ATM in the etiology of breast cancer in Iraqi women by identifying radiotherapy's detrimental impact on molecular factors about 10-20 Gy locally gamma cells, which may have an impact on cancer patients' genetic material (DNA). At the Al-Amel National Hospital for Cancer Management in Baghdad, this study was conducted on 18 breast cancer patients from Iraq. over three months eighteen healthy ladies, aged 35 to 45 years, are non-smokers and non-alcoholics. The results of gene expression show a significant difference in the ATM treatment comparison between the initial and final administration of RT. P value= 0.0047. Specialized primer genes were chosen for the mRNA genes ATM, as well as the primers for the internal control (actin) gene. which has a relationship with Ionizing radiation, using RT-PCR to analyze gene expression. According to the findings, radiation activates the ATM gene, which is involved in the cell cycle, DNA repair, and apoptosis regulation.
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EFFICACY OF ABSORBENT DRESSING AND COMBINATION OF PLATELET-RICH PLASMA WITH POYHEXAMETHYLENE BIGUINIDE BETAINE IN WOUND HEALING OF NECROTIZING CELLULITIS: A CASE REPORT
Journal ID : AMJ-31-07-2022-10331; Author : Anita Berliana, Asnawi Madjid, Khaeruddin Djawad, Safruddin Amin,
Abstract : Necrotizing cellulitis is a necrotizing infection with or without gas formation localized to the skin and subcutaneous tissue but does not involve the underlying fascia and muscles. Management should prioritize timely diagnosis and intervention with appropriate management and antibiotics. It is reported that a 67-year-old male patient with necrotizing cellulitis on the left leg with culture results of staphylococcus aureus was given broad-spectrum systemic antibiotic therapy according to the sensitivity results and treated using absorbent dressing in the form of foam and a combination of platelet-rich plasma (PRP) and polyhexamethylene. Biguanide (PHMB) makes granulation tissue appear rapidly and re-epithelializes complete in 8 weeks. Necrotizing cellulitis is an infection with a lot of exudates and necrotic tissue. Excessive wound infection and exudation were treated with systemic antibiotics and absorbent dressings, and the combination of PRP and PHMB can increase the efficacy of therapy by increasing the granulation tissue formation and epithelialization of wound healing. The success of absorbent dressing therapy and the combination of PRP with PHMB can provide satisfactory therapeutic results and can help the process of new tissue formation and complete epithelialization of necrotizing cellulitis ulcers in 8 weeks.
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Purification and Study the Kinetics Properties of Glucose-6-Phosphate Dehydrogenase from Pediatric Patients with Favism Disease
Journal ID : AMJ-31-07-2022-10330; Author : Zahraa Kadhim Mohammed,
Abstract : In Iraq, The glucose-6-phosphate dehydrogenase gene is an x-linked disease, and its deficiency is common throughout the world. This study was conducted to purify Glucose 6-phosphate dehydrogenase from favism patients and determination [Km, Vmax], and study the effect of optimum temperature, substrate, PH for G6pd in patient and control, the ongoing review presumed that the ideal pH of the enzymatic concentrate was in the reach [8-8.4]. the chemical has the most elevated compelling enzymatic at 8.5 pH for patients. The temperature of protein was steady to 37 ºC for patients and apparently exhibited the most elevated at 40 ºC. The constants were; for Michaelis-Menten of substrate [G6P] and the Vmax were [0.42mM] [27.17UI/ml] for patients and [0.142mM] and [79.36UI\ml] for control respectively.
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Differences between vitamin D levels in premature neonates with respiratory Distress and without respiratory distress
Journal ID : AMJ-30-07-2022-10329; Author : Riyan Agus Faisal Hasibuan, Beby Syofiani Hasibuan, Rizky Adriansyah, Juliandi Harahap, Rosmayanti Siregar, Karina Sugih Arto,
Abstract : Respiratory distress is associated with lung maturation and vitamin D which is explained by the mechanism of production and secretion of phospholipids (surfactants) on the surface of type II alveolar cells (ATII). To determine the differences between in vitamin D levels in premature neonates with respiratory distress in premature neonates and without respiratory distress. Analytical analyses with a case-control study in premature neonates who experienced respiratory distress at the H. Adam Malik Medan General Hospital from September 2021 to March 2022. To assess the difference among variables with t-independent test, Mann-Whitney test, and Kruskal Wallis test. A total of 25 patients with respiratory distress samples and 25 controls were analyzed. Differences between the classification of vitamin D levels in children with respiratory distress and without respiratory distress had a significant (p=0.014) with vitamin D level with respiratory distress of 14.72. The difference between Downe Score and APGAR Score in children with respiratory distress and without respiratory distress also had significance (p=0.001) with a mean of Downe Score of 4.68 and APGAR Score of 5.96 for the first 7.16 for the fifth, and 7.6 for the tenth minutes. The differences between Downe Score and vitamin D levels in the group of infants with respiratory distress did not have a significant (p=0.742). There are significant differences among the classification of vitamin D levels, Downe Score and APGAR Score in neonates with respiratory distress and without respiratory distress. However, there was no significant differences between Downe Score and vitamin D levels.
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The Effectiveness of Physical Exercise on Changes in Vo2max, Muscle Endurance, and Blood hemoglobin levels in athletes
Journal ID : AMJ-30-07-2022-10328; Author : Hasnia Ahmad, Aco Tang1, Djohan Aras, Hendrik Hendrik,
Abstract : Athletes' physical fitness, especially VO2max and muscle endurance, must be increased or maintained because it determines the ability of an athlete to carry out their activities. Physical fitness needs special attention because it is an important element in almost all sports. To determine the effect of physical exercise on changes in VO2max, muscle endurance, and hemoglobin in athletes. This research is a quasi-experimental research with a pre and post-test one-group design with two measurements, before exercise, and after exercise. A total of 40 samples were recruited to participate in this study with predetermined inclusion and exclusion criteria. Physical exercise was given 3 times a week for 2 months. VO2max with bleep test, muscle endurance with half squat jump, and Hemoglobin with routine blood test Results. Physical exercise is very effective on athlete's muscle endurance but is not effective for increasing VO2max and hemoglobin of athletes at the Makassar Student Sports Education and Training Center (PPLP).
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The Effectiveness of Oral and Topical Glutathione on Improving Signs of Skin Aging: A Double-Blind Randomized Controlled Clinical Trial
Journal ID : AMJ-30-07-2022-10327; Author : Siswanto Wahab, Anis Irawan Anwar, Asvina Anis Anwar, Andi Nurhaerani Zainuddin, Ivan Kurniadi, Nuril Ilmi,
Abstract : Glutathione is a well-known potent antioxidant which also possesses skin-lightening and anti-aging properties. Despite its popularity as main ingredients on skin care and supplementation, the anti-aging effect of of oral and topical glutathione combination is unknown. This study aimed to compare the anti-aging effect of oral and topical glutathione combination therapy against monotherapy and placebo. A randomized, double-blind, placebo-controlled clinical trial was conducted on healthy women aged 25-50 years old. The subjects were randomly assigned into one of four intervention groups (I=topical glutathione + oral placebo; II=topical + oral placebo; III=topical + oral glutathione; IV=topical placebo + oral glutathione). The clinical changes on spots, pores, roughness, wrinkles, signs of ultraviolet acnes (UV-A), and ultraviolet spots (UV-S) were assessed biweekly with Janus-II measurement system for a total of 8 weeks. Mann Whitney U test was used to compare the mean difference between each glutathione group (I, III, IV) and placebo group (II). Group IV demonstrated the least increase of spots and significant reduction of pores and roughness compared to placebo (p<0,05). Group I experienced the most reduction in wrinkles and UV spot parameter (p<0,05). Whereas group III shows the biggest improvement on UV acne parameter (p<0,05). The study shows the benefits of topical and/or oral glutathione on defying the skin aging process compared to the placebo. However, the combination of oral and topical glutathione is not as effective as monotherapy, except in UV acne parameter.
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Effectivity of Polidocanol, Ethanol, and Bleomycin as Sclerosing Agent in Vivo
Journal ID : AMJ-29-07-2022-10326; Author : Benny Kurniawan, Muhammad Nuralim Mallapasi, Mulawardi, Jayarasti Kusumanegara, Umar Usman, Firdaus Hamid, M Husni Cangara,
Abstract : This study aims to examine the effectiveness of polidocanol, ethanol and bleomycin as sclerosant agents in the animal model. An experimental study design was performed on 24 Lepus nigricollis rabbits (48 ears) which were divided into three treatment groups: polidocanol (group I, n=16), ethanol (group II, n=16), and bleomycin (group 3, n=16). All animals received treatment by injection into the dorsal vein behind the ear, then damming the vein 10 minutes later. After that, punch tissue samples were taken from blood vessels for 60 minutes, 24 hours, seven days, and 45 days evenly in each group for standard histopathological examination. The severity of histopathology changes was scored by inflammation, proliferation, luminal narrowing and vascular fibrosis. There were no differences in the degree of inflammation, proliferation, luminal narrowing and fibrosis in the three treatment groups with different sclerosing agents and at different times. There was a positive and significant correlation to vascular proliferation, luminal narrowing, and fibrosis over measurement time (all p<0.005). There was a positive and significant correlation to luminal narrowing and fibrosis over measurement time (all p<0.005). There was a positive and significant correlation to inflammation, luminal narrowing, and fibrosis over measurement time (all p<0.005). In conclusion, bleomycin, polidocanol, and ethanol have a similar effectivity as a sclerosing agent in vivo. However, almost histopathology changes significantly correlate with bleomycin, polidocanol, and ethanol over time.
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Quality of Life Factors Associated with Diabetes Mellitus in Patients with Pre-Ulcers: Cross Sectional Study in Takalar Regency
Journal ID : AMJ-29-07-2022-10325; Author : Suardi Suardi, Amran Razak, Ridwan Amiruddind,, Hasanuddin Ishak, Ummu Salmah, Ida Leida Maria, Nursalam Nursalam, Saldy Yusuf,
Abstract : Diabetes mellitus (DM) is a chronic metabolic disease, of which its prevalence remains increased worldwide. So far, the focus of research in several countries is only on DM patients who have experienced diabetic foot ulcers without paying attention or seeing the condition of pre-ulcerss. If pre-ulcers can be controlled from the start, it will improve the condition of DM patients so that the quality of life will also be better. This study aimed to examine factors associated with the quality of life in diabetic patients with pre- ulcers condition. This study was cross-sectional conducted in Takalar regency, Indonesia. Data collection using Questionnaire WHOQOL-BREF is a summary of the World Health Organization Quality Of Life (WHOQOL) which consists of 26 questions. A total of 33 respondents were selected using an accidental sampling method. Data analysis was carried out using the chi-square test with a significant degree of p<0.05. The results showed a relationship between occupational status and the quality of life (ρ=0.049). Similarly, there was a significant association of environment (ρ=0.033) and service quality (ρ=0.017) with the quality of life. There is a relationship between work, environment, and quality of service with quality of life in patients with diabetes mellitus with pre-ulcers in Takalar regency.
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Protective effect of Sweet potato (Ipomoea batatas L.) and Carrot (Daucus carota L.) juices against gastric ulcer induced experimentally
Journal ID : AMJ-29-07-2022-10324; Author : Dina H. Sayed, Amal H. Hamza, Hanan M. F.Abd El-Wahab, Sahar M.Galal, Amina A.S. Abdel Rahman, Fatma H.Abd El-Razik,
Abstract : Gastric ulcer (GU) is a serious gastrointestinal disease, poses a considerable threat to humans, It’s pathophysiology involves an imbalance between mucosal protective and offensive factors. This study highlighted the protective effect of either sweet potato juice (SPJ) carrot juice (CJ) or their combination against gastric ulcer induced by indomethacin. Sixty male adult albino rats Sprague-Dawley strain were equally divided into six groups, group (1) healthy control group, group (2) GU group, group (3) SPJ + GU, group (4) CJ + GU, group (5) mixture of SPJ& CJ (MJ)+ GU, group (6) Omperazole (Omp) + GU. Biochemical investigations include oxidative stress (MDA and NO), antioxidant (SOD, GSH and TAC), inflammatory (IL-6, TNF-α and CRP) and apoptotic biomarker Caspase-3. Also, PGE2, COX-1, pepsin and hydroxyproline. Furthermore, gastric juice was examined for pH, while gastric tissues were examined for ulcer score, ulcer index as well as gene expression level of Hsp70. Histopathology observation of gastric tissues was detected by hematoxylin and eosin (H&E) staining, the expression of Bcl-2 and Bax in gastric tissues were evaluated by immunohistochemistry (IHC). Results obtained from the current study revealed that either SPJ, CJ or the MJ exert a protective effect against GU, shown by a decrease in the gastric ulcer index and score as well as the biochemical parameters in serum. The juices up-regulate the expression of HSP-70 and by up-regulation of Bcl-2 and down-regulation of Bax. SPJ and CJ are therapeutically valuable for enhancing gastric ulcer remediation as they are capable of inhibiting indomethacin-induced damage.
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