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Volume - 63 , Issue 06
30 Jun 2023

Azerbaijan Medical Journal

(ISSN: 0005-2523)

Azerbaijan medical journal (ISSN: 0005-2523) - is a scopus indexed journal since 1961. The publisher of the journal is Izdatel'stvo Elm by WHO Office in Azerbaijan. Azerbaijan medical journal (AMJ) is also UGC approved. The journal publishes general medicine, health science, psychological, pharmaceutical journals and so on. Gongcheng Kexue Yu Jishu/Advanced Engineering Science Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery Tobacco Science and Technology Zhenkong Kexue yu Jishu Xuebao/Journal of Vacuum Science and Technology Kongzhi yu Juece/Control and Decision Changjiang Liuyu Ziyuan Yu Huanjing/Resources and Environment in the Yangtze Valley

Aim and Scope

Azerbaijan Medical Journal

Azerbaijan Medical Journal (ISSN: 0005-2523) - is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to. Zhongguo Shiyou Daxue Xuebao (Ziran Kexue Ban)/Journal of China University of Petroleum (Edition of Natural Science) Teikyo Medical Journal Wuhan Ligong Daxue Xuebao (Jiaotong Kexue Yu Gongcheng Ban)/Journal of Wuhan University of Technology (Transportation Science and Engineering) Zhonghua yi shi za zhi (Beijing, China : 1980) Agricultural Mechanization in Asia, Africa and Latin America International Medical Journal Technology Reports of Kansai University Asia Life Sciences Open Access Journals Tagliche Praxis

Anatomy Physiology Biochemistry Pharmacology Pathology Forensic medicine Microbiology Community Medicine Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases Anaesthesia Cancer research Neurosurgery Orthopedics Gastroenterology Neurology Nephrology Medical education Orthopaedics Paediatrics Reproduction Cardiology Diabetes Surgery Nursing Otolaryngology Dental Psychology Anesthesiology Dermatology Endocrinology Hepatology Urology Venereology Psychiatry Biotechnology Pharmacy ENT Pharmaceutical Chemistry Pharmaceutical Analysis Pharmaceutics Pulmonology Pharmacognosy Pharmaceutical Phatmaceutical Technology Biopharmaceutics Pharmacokinetics Pharmacodynamics Industrial Pharmacy Drug Design Quality Assurance Drug Regulatory Affairs Phytochemistry Drug Delivery Systems Pharmaceutical Nanotechnology Pharmaceutical Microbiology Hospital Pharmacy Clinical Pharmacy Pharmacy Practice Drug Discovery Drug Metabolism Toxicology Clinical Research Pharmacogenomics Phrmacoinformatics Pharmacovigilance< Life Sciences like Chemistry Biomedical Sciences Microbiology Immunology Forensic Epidemiology Oncology Biomedicine Dentistry Physiotherapy Gynaecology Dermatoepidemiology Neuroscience Ophthalmology Sexology Osteology Kinesiology Angiology/Vascular Medicine Critical care Medicine Haematology Infectious Diseases and Vaccinology Bariatrics Pharmacy and Nursing Pharmacognosy and Phytochemistry Radiobiology Clinical immunology Clinical and Hospital Pharmacy Cell Biology Genomics and Proteomics Healthcare Services Healthcare Management Bioinformatics and Biotechnology Geriatric Medicine Bulletin of National Institute of Health Sciences Journal of the Austrian Society of Agricultural Economics Gongcheng Kexue Yu Jishu/Advanced Engineering Science Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery Tobacco Science and Technology Zhenkong Kexue yu Jishu Xuebao/Journal of Vacuum Science and Technology Wuhan Ligong Daxue Xuebao (Jiaotong Kexue Yu Gongcheng Ban)/Journal of Wuhan University of Technology (Transportation Science and Engineering) Zhonghua yi shi za zhi (Beijing, China : 1980) Zhongguo Shiyou Daxue Xuebao (Ziran Kexue Ban)/Journal of China University of Petroleum (Edition of Natural Science) Teikyo Medical Journal Kongzhi yu Juece/Control and Decision Changjiang Liuyu Ziyuan Yu Huanjing/Resources and Environment in the Yangtze Valley

Latest Journals

Azerbaijan Medical Journal

Agricultural Mechanization in Asia, Africa and Latin America International Medical Journal Technology Reports of Kansai University Asia Life Sciences Open Access Journals Tagliche Praxis Bulletin of National Institute of Health Sciences Journal of the Austrian Society of Agricultural Economics
A Simple demonstration to comprehend the application of Laplace law in human physiology
Journal ID : AMJ-13-11-2022-10780; Author : Kamalakannan Vadivel, Prashanth Talikoti, Lord Krishna Govindaraju, Nilesh N Kate,
Abstract : The Laplace law relates the wall tension with the radius of curvature and the pressure in hallow structures. It is expressed as tension T is directly proportional to the product of the radius of the curvature r, and the pressure p, in the hallow structure. The expression is quite straight forward and easy to understand. The difficulty arises when the law is applied to understand the physiological process, as many a times students tend to understand that tension and pressure changes unidirectionally, and therefore tend to believe that the estimate which they directly feel by palpating the hallow structure is pressure rather than tension. To make them understand the difference, a simple demonstration was done using a balloon and a needle to make the concept clear. The model presented here is less expensive and is of use in resource limited settings. The demonstration of the Laplace’s law using this techniques was found to be helpful in intuitive understanding of this basic biophysical principle in comprehending physiological principles based on Laplace’s law.
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Significant reduction of serum coenzyme Q10 in pediatric nephrotic patient with steroid resistance in comparison with steroid sensitive and control groups
Journal ID : AMJ-13-11-2022-10779; Author : Rasha K.J. Ali, Omar F. Abdul-Rasheed, Mohammed Abed Darweesh,
Abstract : Steroid-resistant nephrotic syndrome is a causative agent of end-stage kidney disease in children and young people. A genetic factor is responsible for around 30% of children with steroid resistance. In the first decades of the new century, research has revealed a role for CoQ in the regulation of gene expression, mitochondrial activity, and cell signaling. Primary CoQ10 insufficiency may be susceptible to treatment with CoQ10 supplements by omitting the biosynthetic deficiencies. The objective of present research: Analyze the association between steroid response coenzyme Q10 serum levels. HPLC evaluate serum coenzyme Q10 in total 80 patients with NS (40 SRNS and 40 SSNS) and 80 health control of Iraqi origin. Highly significant difference in COQ serum level between control and nephrotic groups (p˂0.001). This is the first research project of its kind in Iraqi origin to look the relation between serum COQ10 level and pediatric steroid resistance nephrotic syndrome .serum Q10 as diagnostic biomarker in patient with ADCK4 associated SRNS.
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Analysis Of Sleep Disorder In Acute Lymphoblastic Leukemia
Journal ID : AMJ-13-11-2022-10777; Author : Minda Hadiyanti Lubis, Olga Rasiyanti Siregar, Rizky Adriansyah,
Abstract : Acute lymphoblastic leukemia (ALL) is the most common cancer in children and adolescents. Chemotherapy for leukemia has many side effects, toxicity, and length of stay that will affect the patient's quality of life. One of the factors that contribute to children's quality of life, including in the case of leukemia, is sleep disorder. The aim of this study is to analyze the risk factors that cause sleep disorder in ALL. This study is an analytic study with a cross-sectional design conducted in children with a diagnosis of acute lymphoblastic leukemia at Haji Adam Malik General Hospital Medan who met the inclusion and exclusion criteria from October 2021 to April 2022. Subject's parents were interviewed based on the questions on the CSHQ questionnaire. Out of 50 children with acute lymphoblastic leukemia, 33.3% of male and 45% of female in this study had sleep disorders. Based on nutritional status, 63.2% of children with normal nutritional status and 22.6% of malnourished children experienced sleep disorders. Based on the type of medication, 50% of children given prednisone therapy experienced sleep disorders. Prednisone is the most chemotherapy treatment agent and it has sleep disorder effect in ALL patients, there is a significant partial association between nutritional status and sleep disorders in children with ALL, there is a significant association between the type of medication and sleep disorders in children with ALL.
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Fennel Seeds (Foeniculum Vulgare M.) and Khellah Seeds (Ammi Visnaga L.) Downregulate KIM-1 and NFAT-5 Genes Expression in LPS-Induced Nephrosis
Journal ID : AMJ-12-11-2022-10775; Author : Amira Abd El-Rhman, Huda E. Megahd,
Abstract : Acute kidney injury (AKI) is a significant biomedical issue stimulated by many signaling pathways by lipopolysaccharide (LPS). This study looked at how fennel and khellah seed extracts (FSE&KSE) ameliorate the nephrosis that LPS-induced in experimental rats. Forty healthy adult male Westar albino rats weighing 200±20g, were used. Ten rats were left as control group G1, while other 30 rats were received a single intraperitoneal injection by LPS (12mg/kg b. wt.) and then divided into 3 groups 10 rats for each. G2 represented the positive control, however the remaining two groups treated orally by FSE and KSE for 4 weeks. The injection of LPS increased KIM-1 and NFAT-5 genes expression, inflammatory biomarkers, nephrotic proteinuria moreover histological and structural changes in kidney tissue, while administration of FSE and KSE resulted in a significant (P˂0.05) improvement in biochemical parameters and ameliorate structural changes in kidney tissue and down regulate of KIM-1and NFAT-5 genes expression related to protect kidney from LPS injury.
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Gerontology training in Bulgaria - from current postgraduate activities to conceptual pregraduate education
Journal ID : AMJ-12-11-2022-10774; Author : Tanya Bozhkova, Georgi Tomov, Nina Musurlieva,
Abstract : The paper addresses current demographic situation in Bulgaria with the focus on the increased need for specialized dental care of the elderly patients. The educational activities of the Problem group on gerodontology (PGG) is briefly presented together with the analysis of the needs for pregraduate education in this field. Based on this analysis, the PGG has developed a program for dental students in gerodontology, as part of their specialized training. The program is adapted both to the recommendations of the European College of Gerodontology in the Undergraduate curriculum guidelines in Gerodontology and to the national requirements and policies.
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Pandalungan Culture Study on Dietary Patterns and Physical Activity related to the risk of Diabetes and or Obesity
Journal ID : AMJ-11-11-2022-10773; Author : Ancah Caesarina Novi Marchianti, Dwita Aryadina Rachmawati, Elly Nurus Sakinah,
Abstract : Diabetes and or obesity have a genetic predisposition, but it is unlikely that genes can change drastically over a short time, thus, the incidence of increased incidence is more related to lifestyle factors than genetic factors. A combination of diet restriction and exercise is effective in preventing the onset and severity of diabetes and or obesity. Pandalungan community is unique because of acculturation from a traditional to a modern lifestyle, therefore, we were interested to investigate dietary patterns and physical activity (PA) as one of the lifestyle factors that may cause obesity and diabetes in this community. We analysed 1200 research subjects of healthy, obese, and or diabetic adults in the Pandalungan area, East Java, Indonesia. The research results are able to show or aid to filter which acculturation is good and which one should be rejected related to the risk of diabetes and or obesity in the Pandalungan community. Pandalungan culture had shown similar results on the variety of PA in adults with the most active domain being the household domain. Statistical analysis showed that there was no significant relationship between PA and blood glucose level (p>0.05) but when comparing dietary patterns, it showed that type of food and eating schedule related significantly. The household domain became a major PA probably because the Pandalungan culture comes with very solid family ties. Pandalungan people need to pay attention to their preference for food and their schedule of eating.
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Uric acid to High density lipoprotein cholesterol ratio as an early screening biomarker for coronary artery disease
Journal ID : AMJ-11-11-2022-10772; Author : Balasubramanian Arumugam, Meera V, Prashanth Talikoti, Sundhar Nedunchezhian, Udayakumari G,
Abstract : Coronary artery disease (CAD) is more prevalent among the Indian population with significant morbidity and mortality. Various inflammatory and lipid markers are available for the diagnosis of CAD but with huge cost. Recently uric acid has been found to play a significant role in the progression of CAD. So the present study was done to find the diagnostic ability uric acid to high density lipoprotein cholesterol ratio in the prediction of CAD. This was a case control study done on forty patients and they were designated as cases (n=20), patients diagnosed with CAD and controls (n=20) who were healthy volunteers. Various biochemical markers such as lipid, liver and kidney profiles, uric acid and UHR levels were analyzed. Unpaired student t test was used to compare between the groups. Receivers operating curve was performed to find the diagnostic accuracy. In this study, the lipid profiles were significantly elevated in cases as compared to controls. The UHR levels were elevated in cases as compared and it was significant (0.19 ±0.008 vs 0.08 ± 0.001 p=0.00001. Based on the ROC curve the sensitivity and specificity for UHR for cut off value of 11 was found to be 90% and 90%. UHR is a cheap and effective diagnostic marker in the prediction of CAD and it can be used in all healthcare facilities.
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Central Cornea Thickness and Keratocyte Cell Density After Transglutaminase-Induced Corneal Collagen Crosslinking
Journal ID : AMJ-11-11-2022-10771; Author : Yulia Primitasari, Puspita Hapsari Sitorasmi, Yuniar Sarah Ningtiyas, Indri Wahyuni,
Abstract : Corneal collagen crosslinking is a procedure for making bonds that connect polymer chains. Corneal collagen crosslinking aims to slow or stop the progression of keratoconus by using photooxidative therapy to increase stromal rigidity. This research is aimed to evaluate the effect of transglutaminase-induced corneal collagen crosslinking (CXL) on central corneal thickness and keratocyte cell density in vivo. Twenty-eight white New Zealand rabbits were divided into four groups: the transglutaminase-induced CXL group, the epithelial-off CXL group, the transepithelial CXL group, and the control group. The ocular surface was treated with a 1 U/mL microbial transglutaminase solution, and both the epithelial-off and transepithelial groups were exposed to clinical ultraviolet A-riboflavin (UVA/RF). The efficacy of each group was evaluated on the 14th day after the procedures. Central corneal thickness and keratocyte cell density were evaluated with histopathology examination. Transglutaminase-induced CXL group exhibited the highest mean central corneal thickness (341.10 ± 58.50) in comparison to the UVA/RF epithelial-off group (289.42 ± 38.19), the UVA/RF transepithelial group (319.15 ± 16.81) and control group (318.40 ± 63.97). Still, there was no significant difference, with a p-value of 0.279. Transglutaminase-induced CXL group had the highest mean of keratocyte cell density (43.26 ± 10.65) compared to UVA/RF epithelial-off (29.99 ± 4.79), UVA/RF transepithelial group (42.03 ± 6.55), and control group (34.36 ± 6.76). There was a significant difference between the group, with a p-value of 0.008. It implied that the effect of transglutaminase-induced CXL could be comparable to UVA/RF CXL in altering central cornea thickness and keratocyte cell density.
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Bacterial Profiling And Antibiotic Susceptibility Isolated From Infection Cases In Dr. Soebandi Regional Hospital, Indonesia
Journal ID : AMJ-11-11-2022-10770; Author : Diana Chusna Mufida, I Nyoman Semita,
Abstract : Hospital-Acquired Infection (HAI) is one of the highest causes of morbidity and mortality in patients treated in hospitals from bacteria in hospital environments, such as air, water, surfaces, or even medical equipment. The provision of broad-spectrum antibiotics and their combination can cause the bacteria to resist antibiotics. Microbial and antibiotic sensitivity profiling can reduce the resistance rate of bacteria. This research is expected to improve the health status of Indonesian citizens, especially in the area of dr. Soebandi Regional Hospital of Jember. This research used a descriptive research method with a prospective approach using primary data taken from patient's laboratory examinations on aspiration/pus/blood/urine/ sputum/vaginal secretions/CSF/infectious wound/ulcer patients of dr. Soebandi Regional Hospital from January 1st until December 31st, 2019. The patient’s specimen results culture showed positive results in 219 patients. The most common type of infection was sputum infection (43%) and pus infection (42%). The majority type of bacteria is gram-negative (78.5%) and dominated by K. pneumoniae, Escherichia coli, and Pseudomonas aeruginosa. Gram-positive bacteria are found in 47 patients (21.4%), with the most common species are Kocuria varians, Streptococcus sp., and Staphylococcus aureus. The antibiotics with the highest sensitivity were doxycycline for gram-positive and antibiotic for gram-negative are amikacin and piperacillin-tazobactam.
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Evaluation of some immune biomarkers in doxorubicin-induced cardiactoxicity in rats model after Omega3
Journal ID : AMJ-10-11-2022-10767; Author : -Haneen kadhim al-hassani , department of Pharmacology and Taxology / collage of pharmacy / Mustansiriyah university / Iraq, Prof. Dr. Suhad Faisal Hatem , department of clinical laboratories sciences/ collage of pharmacy / Mustansiriyah university / Iraq, Ass.Prof. Dr. Yassir Al-Mulla Hummadi, , department of Pharmacology and Taxology / collage of pharmacy / Mustansiriyah university / Iraq,
Abstract : The leading causes of death in both developed and developing countries are cardiovascular diseases (CVD) and cancer. The importance of doxorubicin, as a potent antitumor antibiotic and induce cardiocytotoxicity was studied. It is commonly used against ovarian, breast, lung, uterine and cervical cancers, soft tissue and primary bone sarcomas. Omega-3 fatty acids are regarded as immune-nutrients and are commonly utilized in the nutritional therapy of cancer patients. According to our knowledge there is no study linked the effects of Omega-3 on the immune markers level among DOX-induce cardiotoxicity, Therefore, goals of this study was to assess the potential protective effects of Omega-3 fatty acids on cardiotoxicity caused by DOX by measuring T(cTn- T) and some immune biomarkers include CCL23,CCL27,MIF in rats model using Eliza technique. The rats were divided into five equal groups. Group 1 got no treatment, group 2 received doxorubicin single toxic dose 20mg/kg IP, and groups 3,4,5 received doxorubicin toxic dose 20mg/kg IP following pretreatment with Omg-3 at different doses (100m, 200, 400 g/kg /day p.o) for 4 weeks, respectively. At the end of the experiment, blood samples were collected from the heart for measurement of plasma levels of cardiac troponin T (cTn- T) and serum levels of immune-biomarker (CCL23,CCL27,MIF) using the ELIZA technique, and the apical side of the heart was fixed in 10% formalin for histological examination. In comparison to the control group, pretreated Omg-3 groups with doses showed a highly significant reduction in the mean of the concentration of markers include cTn-T,CCL23,CCL27, MIF with p <0.001, while they showed significantly elevated mean in DOX alone group (P≤0.01). The histopathology results showed that groups pretreated with Omg-3 reduced the myocytes necrosis and granulation tissues with mild signs of sarcoplasmic vacuolization and inflammation regarding to the doses dependent effect. The results of the present study revealed that Omg-3 have been shown to decrease doxorubicin-induced cardiotoxicity and showed a valuable cardioprotection effect through suppression of some immune-biomarkers and change the histopathological features of cardiomyocytes.
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