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Azerbaijan Medical Journal

(ISSN: 0005-2523)

Azerbaijan medical journal (ISSN: 0005-2523) - is a scopus indexed journal since 1961. The publisher of the journal is Izdatel'stvo Elm by WHO Office in Azerbaijan. Azerbaijan medical journal (AMJ) is also UGC approved. The journal publishes general medicine, health science, psychological, pharmaceutical journals and so on.

Aim and Scope

Azerbaijan Medical Journal

Azerbaijan Medical Journal (ISSN: 0005-2523) - is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to.

Anatomy Physiology Biochemistry Pharmacology Pathology Forensic medicine Microbiology Community Medicine Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases Anaesthesia Cancer research Neurosurgery Orthopedics Gastroenterology Neurology Nephrology Medical education Orthopaedics Paediatrics Reproduction Cardiology Diabetes Surgery Nursing Otolaryngology Dental Psychology Anesthesiology Dermatology Endocrinology Hepatology Urology Venereology Psychiatry Biotechnology Pharmacy ENT Pharmaceutical Chemistry Pharmaceutical Analysis Pharmaceutics Pulmonology Pharmacognosy Pharmaceutical Phatmaceutical Technology Biopharmaceutics Pharmacokinetics Pharmacodynamics Industrial Pharmacy Drug Design Quality Assurance Drug Regulatory Affairs Phytochemistry Drug Delivery Systems Pharmaceutical Nanotechnology Pharmaceutical Microbiology Hospital Pharmacy Clinical Pharmacy Pharmacy Practice Drug Discovery Drug Metabolism Toxicology Clinical Research Pharmacogenomics Phrmacoinformatics Pharmacovigilance< Life Sciences like Chemistry Biomedical Sciences Microbiology Immunology Forensic Epidemiology Oncology Biomedicine Dentistry Physiotherapy Gynaecology Dermatoepidemiology Neuroscience Ophthalmology Sexology Osteology Kinesiology Angiology/Vascular Medicine Critical care Medicine Haematology Infectious Diseases and Vaccinology Bariatrics Pharmacy and Nursing Pharmacognosy and Phytochemistry Radiobiology Clinical immunology Clinical and Hospital Pharmacy Cell Biology Genomics and Proteomics Healthcare Services Healthcare Management Bioinformatics and Biotechnology Geriatric Medicine

Latest Journals

Azerbaijan Medical Journal

The Effect of an Animation Video on Pain Response of 3-6 Years Old during Injection Intravenous
Journal ID : AMJ-23-08-2022-10467; Author : Islaeli Islaeli, Faridah Mohd Said, Nisha Nambiar,
Abstract : Animated videos are one of the easiest ways to play when the child receives a medicine injection via an intravenous catheter that might reduce pain response. This study aimed to determine the effect of animation video on pain response for 3-6 years old during injection medicine via intravenous catheters. The study employed a quasi-experimental pre-test - post-test design. The intervention group (n: 107) was provided with an animation video during intravenous therapy, and the control group (n: 106) received standard care. FLACC (r: 0.845) was used to measure behavioural pain response, while heart rate was used to assess physiological pain response. Animation video with content validity index (Aiken’s V: 0.86). There were statistically significant differences in pain response, behavioral pain response, and physiological pain response between the intervention group and the control group. Animation video intervention can be used to reduce procedural pain during injection medicine intravenous therapy.
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Evaluation of the locally applied doxycycline on alveolar osteitis incidence following surgical removal of impacted mandibular third molars
Journal ID : AMJ-23-08-2022-10466; Author : Rasheed Musleh Ibrahem, Assist. Prof. Dr. Ali H. Abbas Al Hussaini,
Abstract : One of the most common oral procedures carried out every day in oral and maxillofacial surgery units is the surgical removal of impacted mandibular third molars. After the impacted mandibular third molar has been removed, postoperative morbidity is unavoidable. Alveolar osteitis, a painful, unhealed socket, is one of the most frequent surgical sequelae. By introducing and applying a new material inside the extraction socket, many researches were attempted to prevent the development of alveolar osteitis. This study aims to make a comparison between the effect of the locally applied Doxycycline and the systemic Doxycycline on the occurrence of alveolar osteitis after surgical removal of impacted mandibular third molars. A randomized prospective clinical study was conducted on 50 patients who had undergone surgical removal of impacted mandibular third molars under local anesthesia. The patients were distributed in 2 groups: Study group; included 25 patients treated by local application of Doxycycline inside the socket immediately after surgical removal of impacted tooth. Control group: consisted of 25 patients who received systemic Doxycycline one hour before surgical removal of impacted tooth. Alveolar osteitis was evaluated on the 2nd and 7th day after surgery. There was a significant reduction of alveolar osteitis in the study group in comparison to the control group (p< 0.05). The local application of Doxycycline significantly reduces the incidence of alveolar osteitis.
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Effectiveness of locally applied clindamycin on the occurrence of alveolar osteitis following surgical removal of impacted mandibular third molars. A comparative study
Journal ID : AMJ-23-08-2022-10465; Author : Dashti Ali Mohammed, Assist. Prof. Dr. Ali H. Abbas Al Hussaini,
Abstract : One of the most frequent procedures in oral surgery units is the removal of a partially or completely impacted mandibular third molar under local anesthesia and it directly affects the patient's quality of life. The aim of this study is to make a comparison between the effect of the locally applied clindamycin and the systemic clindamycin on occurrence of postoperative alveolar osteitis following surgical removal of impacted mandibular third molars. Fifty patients who had undergone the surgical removal of an impacted mandibular third molar under local anesthesia participated in a randomized prospective clinical study. The patients were distributed in 2 groups. Study group included 25 patients treated with local application of clindamycin inserted inside the socket after surgical removal of impacted tooth, while control group comprised of 25 patients treated with systemic clindamycin one hour before surgical removal of the impacted tooth. The occurrence of alveolar osteitis was evaluated on the 2nd and 7th day postoperatively. Alveolar osteitis occurred on the 48 hours postoperatively. The total incidence of alveolar osteitis was 10%. The incidence of alveolar osteitis was more in control group (16%) when compared to study group (4%) and the difference was statistically significant. Local application of saturated gelfoam by clindamycin reduces the incidence of alveolar osteitis to a significant level when compared to systemic clindamycin.
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Association between BsmI (rs1544410) and TaqI (rs731236) VDR Gene Polymorphisms with Vitamin D Status in Type 2 Diabetes Mellitus Patients
Journal ID : AMJ-22-08-2022-10464; Author : Sufitni Sufitni, T. Helvi Mardiani, Yunita Sari Pane, Siti Syarifah, Mutiara Indah Sari,
Abstract : Type 2 Diabetes Mellitus (T2DM) arises due to combination of modifiable and non-modifiable. One of the modifiable risk factors is vitamin D concentration, which is associated with the incidence of T2DM and mediated by the vitamin D receptor (VDR). The aim of this study is to see the association between BsmI (rs1544410) and TaqI (rs731236) VDR gene polymorphisms with vitamin D status in T2DM patients in the city of Medan, Indonesia. 76 T2DM patients were enrolled in this study. The vitamin D levels are analyzed with enzyme-linked immunosorbent assay (ELISA). Genotyping of BsmI (rs1544410) and TaqI (rs731236) VDR gene polymorphisms are done with Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) technique. In this study, 72.4% of T2DM patients have insufficient and deficient vitamin D status (35.50% and 36.9% respectively). Fisher's exact analysis of the association between vitamin D status with BsmI (rs1544410) and TaqI (rs731236) VDR gene polymorphisms is at p > 0.05, respectively. This study shows that genotype Bsm1 and genotype Taq1 are not associated with vitamin D status in T2DM patients.
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Bitter Gourd (Momordica charantia L.) Affects the Pharmacokinetics Profile of Metformin in Rabbits’ Plasma
Journal ID : AMJ-22-08-2022-10463; Author : Asri Dwi Endah Dewi Pramesthi, Agung Endro Nugroho, Endang Lukitaningsih,
Abstract : The drug-herb combination between metformin and bitter gourd needs further study of the benefits and risks. This study aims to explore metformin in plasma samples using the HPLC method and its pharmacokinetic profiles affected by the bitter gourd. This experimental method study with a post-test randomized controlled group design. Healthy albino rabbits were divided into three groups (n=3). They were administered with bitter gourd juice 100% (4 ml/kg BW) and metformin (BM1), bitter gourd juice 50% (4 ml/kg BW), and metformin (BM2), and metformin 26 mg/kg (M). BM1 and BM2 were given bitter gourd juice for 14 days, and then a single dose of metformin was given to all groups on the 15th day before metformin pharmacokinetic parameters were measured. Blood samples were collected from marginal ear vein punctures at 0, 10, 30, 60, 120, 240, 360, and 480 minutes. The plasma was analyzed using HPLC methods, and the concentration vs. time was used for a 1-compartmental open model pharmacokinetics analysis. Bitter gourd juice with 100% (4 ml/kg BW) concentration decreased the V/F and CL/F, also increased Ka, T1/2, Cmax, MRT, and AUC0-inf, also significantly increased AUC0-480, and decreased Tmax (p < 0.05). The pharmacokinetic interaction of metformin and Momordica charantia L. is presumably because of the competitive interaction between phytochemical constituents of bitter gourd and metformin on the OCT and MATE transporter.
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The Effectiveness of Education on Farmer Knowledge and Behaviors towards COVID-19 Prevention: A Study in an Agricultural Area
Journal ID : AMJ-22-08-2022-10462; Author : Yarmaliza, Teungku Nih Farisni, Fitriani, Zakiyuddin, Fitrah Reynaldi, Veni Nella Syahputri, Andi Imam Arundhana,
Abstract : Following the healthcare and sanitation protocol has been widely used to prevent COVID-19 transmission. The research objective was to determine the effectiveness of WASH educational collaboration on farmers as an attempt to COVID-19 prevention. This study was an observational pre-experimental pretest-posttest design study without a control group. This research was carried out in March 2021, located in two districts with high COVID-19 positive cases, Johan Pahlawan and Meureubo Districts, West Aceh, Indonesia. A total of 37 farmers were recruited as the study participants. Data were analysed using logistic regression. The study result shows a significant influence between the collaboration of WASH education on farmers to prevent COVID-19. The statistical test was significant at a p-value <0.05. Collaboration on WASH education for farmers is very influential in preventing COVID-19. It is believed that cross-sectoral involvement and roles can be maintained so that COVID 19 prevention behaviours through WASH can continue to be applied. Educative collaboration of WASH impacts the alteration of the behaviour toward farmers who live in the area confirmed to be infected by COVID 19.
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PERFORMANCE OF MULTIPLEX REAL TIME PCR FOR DIAGNOSIS MALARIA IN FOREST ENDEMIC AREAS IN TANAH BUMBU REGENCY SOUTH KALIMANTAN PROVINCE INDONESIA
Journal ID : AMJ-22-08-2022-10461; Author : Istiana Istiana, Usman Hadi, Heny Arwati,
Abstract : Malaria incidence has declined in Indonesia for years, but it is still found a foci malaria in forest areas. Rapid Diagnostic Test (RDT) has been used as a diagnostic tool in remote forest areas because other tests are difficult to carry out due to poor infrastructure. Microscopic examination requires expert personnel to determine the right interpretation. The disadvantage of both methods of diagnosis is that they cannot detect the low density of parasites, causing the diagnosis to be missed. For this reason, it is necessary to examine the molecular diagnosis to determine the right species. This cross-sectional study was conducted on 105 people aged 15-64 years in forest malaria endemic areas who were randomly selected. The diagnosis of malaria is established through rapid diagnostic test, microscopic, real-time PCR examination for identification of genus, and multiplex real time PCR for species identification. The performance of multiplex real time PCR, microscopic and RDT was compared and evaluated each other. From 105 blood samples, RDT identified 38 malaria cases, consist of 9 as Plasmodium falciparum infection, 9 as Plasmodium vivax and 20 as mixed infection. Light microscopy identified 9 as P. falciparum infection, 5 as P. vivax infection and 5 as mixed infection. Multiplex real time PCR detected 7 as P. falciparum infection, 6 as P. malariae infection, and 4 as mixed P. vivax and P. malariae infection. Using microscopy as a reference test, real time PCR showed an overall sensitivity of 100% and specificity of 91,9%. Multiplex real time PCR for species P. falciparum had 77,8% sensitivity and specificity of 91,83%. RDTs sensitivity of 94,7% and specificity of 76,4%. Using multiplex real time PCR as a reference, microscopy had shown better performance than RDT with sensitivity 73,7% and specificity 100% but RDT had low sensitivity with 14,3% (95% CI 11,45 – 26,87) and specificity of 70,5% (95% CI 65,78-79,67). All three tests performed well to diagnose malaria in this area, but multiplex PCR performed better for detecting Plasmodium species, especially species that produce submicroscopic infections or subpaten infections. Multiplex real-time PCR is the most sensitive malaria diagnostic method that can be used in malaria elimination programs. It has better performance in species identification, species detection with low parasitic density and mixed infection.
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Molecular Co- Localization of Human Papilloma Virus 6 / 11 in Combined Resected Tissues from Non-oncologic Palatine and Pharyngeal Tonsillar Hypertrophies
Journal ID : AMJ-22-08-2022-10460; Author : Saad Hasan Mohammed Ali, Ameen Abdul Hasan Al-Alwany, Khalil Ismail A. Mohammed, Wifaq M. Ali, Suha A. AL-Fakhar, Shakir H. Mohammed Al-Alwany, Jinan M. Mousa,
Abstract : More than 450 distinct types of human papilloma virus recognized via recent molecular techniques. The low and high oncogenic risk-HPV genotypes have an association with a variety of benign and malignant tumors in the oropharyngeal and nasopharyngeal localizations. This study aimed to determine the rate of DNA detection of HPV genotype 6/11 in non-oncologic nasopharyngeal and palatine tonsillar tissues from pediatric patients subjected to adeno-tonsillectomies. A total number of 64 tissue specimens enrolled; 44 non-oncologic nasopharyngeal and palatine hypertrophied tissue specimens from 22 pediatric patients sustained combined adeno-tonsillectomies and compared to 20 nasal trimmed tissues with unremarkable pathological changes (included as apparently healthy control tissues). Recent version of chromogenic in situ hybridization method used for HPV 6/11 DNA detection performed via DNA probes specified for HPV 6/11 low oncogenic - risk genotypes. Among a total 44 tissue specimens obtained from 22 pediatric patients who sustained surgical operations for combined non-oncologic nasopharyngeal and palatine tonsillar hypertrophies, 10 combined nasopharyngeal as well as palatine tonsillar hypertrophied tissues out of 22 combination of such tissues found to contain positive CISH reactions results for HPV 6 / 11 DNA, constituting 45.5% of the total screened tonsillar tissues. No positive– CISH reactions detected in the control tissues. Statistically, a significant difference showed when compared to the control apparently healthy nasal tissues. The significantly detected rates of these low- oncogenic HPV genotypes in both nasopharyngeal and palatine tonsillar hypertrophied tissues are pointing for a one important reservoir tissue site for such infection. In addition, indicating a herald mark for exploring the transmission and pathogenesis dilemma of such an important sexually transmitted infection among, at least, this group of pediatric Iraqi general population.
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Effect ofPhytosterols Fraction of Iraqi CicerarietinumIn Experimentally Induced Hyperlipidemic Mice
Journal ID : AMJ-22-08-2022-10459; Author : Nihal Ramadhan Hwerif, Ahmed Rahmah Abu Raghif,
Abstract : The aim of this study is to evaluate the antihyperlipidemic effect of Phytosterolsfraction of Iraqi Cicerareitinum in high-fat diet (HFD)-fed mice. Animals were divided into (4) groups, for each group (n =8). The total duration of the study was (56) days split into two intervals. During the first 28-days interval, mice were administered with HFD, whereas during the second 28-days interval, they were co-administered HFD plusPhytosterols (500mg/kg: p.o.) or the standard drug Atorvastatin(10mg/kg: p.o.). Phytosterolstreatment to HFD-induced hyperlipidemic mice caused a high significant decrease in the levels of total cholesterol (TC), triglycerides (TG), LDL-C and VLDL-C. Moreover, Phytosterolsresulted in a high significant increase in the levels of HDL-C, whereas it caused remarkable decreases in ALT, AST and ALP enzymatic activities also in total serum bilirubin (TSB) levels among hyperlipidemic mice. Besides that, Phytosterolstreatment showed significant improvement in levels of tissue MDA and GSH in hyperlipidemic mice. Histopathological examination of hyperlipidemic mice group showed marked and diffused cytoplasmic fatty infiltration which was all ameliorated by Phytosterolsadministration. The results revealed that Phytosterols(500mg/kg; p.o) possess potential ameliorating benefits against hyperlipidemia induced by HFD on lipid profile, liver function enzymes, oxidative stress parameters, hepatic and aorta histoarchitecture. Further investigations are recommended to assess the efficacy and to fully dissect the mode of action the observed anti-hyperlipidemic effect of Phytosterols.
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Study the relation between IL-17 rs2275913 gene polymorphism with H. pylori infection in Babylon province
Journal ID : AMJ-20-08-2022-10454; Author : Zahraa Alaa Abd Alhassan Hadi, Nktel Faaz Nassir AL-saad,
Abstract : The current investigation aims to establish a connection between IL17 gene polymorphisms and H. pylori infection. Seventy-eight (78) cases were gathered with H. pylori infection-related clinical symptoms. Urea breath testing and rapid Ab immunoassay, two assays, identified 45 patients with H. pylori infection. As a control group, samples from 45 people were collected who appeared to be in good health. It has been determined that the gold standard method for non-invasive diagnosis is the urea breath test. Additionally, the interleukin 17 gene was found using ELISA, sequencing, and conventional PCR methods. It was discovered that genotype A/A was more closely related to infection, but genotype G/A provided carriers with a lesser susceptibility to infection. This demonstrated the link between H. pylori infection and phenotypes. The risk allele is represented by allele A, with a 95% confidence interval (CI) of 2.30 (1.25–4.21), whereas the protective allele is represented by allele G, with a CI of 0.43 (odd) (0.24–0.80). The mean concentration of interleukin 17 in the H. pylori infection group was 97.85±39.54 pg/ml, which was higher than the 75.58 ±22.74 pg/ml in the control group. The A/A genotype in the IL-17 gene (rs2275913) showed the highest concentration of IL-17 (114.24 pg/ml) in the serum of these studied groups, while the average serum level of the G/A (78.37 pg/ml) and G/G groups (76.13 pg/ml) was obtained from the comparison between the level of IL-17 and the genotypes of the IL-17 gene.
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