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30 Jun 2023

Azerbaijan Medical Journal

(ISSN: 0005-2523)

Azerbaijan medical journal (ISSN: 0005-2523) - is a scopus indexed journal since 1961. The publisher of the journal is Izdatel'stvo Elm by WHO Office in Azerbaijan. Azerbaijan medical journal (AMJ) is also UGC approved. The journal publishes general medicine, health science, psychological, pharmaceutical journals and so on. Gongcheng Kexue Yu Jishu/Advanced Engineering Science Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery Tobacco Science and Technology Zhenkong Kexue yu Jishu Xuebao/Journal of Vacuum Science and Technology Kongzhi yu Juece/Control and Decision Changjiang Liuyu Ziyuan Yu Huanjing/Resources and Environment in the Yangtze Valley

Aim and Scope

Azerbaijan Medical Journal

Azerbaijan Medical Journal (ISSN: 0005-2523) - is a peer-reviewed journal. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to. Zhongguo Shiyou Daxue Xuebao (Ziran Kexue Ban)/Journal of China University of Petroleum (Edition of Natural Science) Teikyo Medical Journal Wuhan Ligong Daxue Xuebao (Jiaotong Kexue Yu Gongcheng Ban)/Journal of Wuhan University of Technology (Transportation Science and Engineering) Zhonghua yi shi za zhi (Beijing, China : 1980) Agricultural Mechanization in Asia, Africa and Latin America International Medical Journal Technology Reports of Kansai University Asia Life Sciences Open Access Journals Tagliche Praxis

Anatomy Physiology Biochemistry Pharmacology Pathology Forensic medicine Microbiology Community Medicine Otorhinolaryngology Internal Medicine General Surgery Obstetrics and Gynecology Radiology Pulmonary Medicine Dermatology and Venereal diseases Infectious Diseases Anaesthesia Cancer research Neurosurgery Orthopedics Gastroenterology Neurology Nephrology Medical education Orthopaedics Paediatrics Reproduction Cardiology Diabetes Surgery Nursing Otolaryngology Dental Psychology Anesthesiology Dermatology Endocrinology Hepatology Urology Venereology Psychiatry Biotechnology Pharmacy ENT Pharmaceutical Chemistry Pharmaceutical Analysis Pharmaceutics Pulmonology Pharmacognosy Pharmaceutical Phatmaceutical Technology Biopharmaceutics Pharmacokinetics Pharmacodynamics Industrial Pharmacy Drug Design Quality Assurance Drug Regulatory Affairs Phytochemistry Drug Delivery Systems Pharmaceutical Nanotechnology Pharmaceutical Microbiology Hospital Pharmacy Clinical Pharmacy Pharmacy Practice Drug Discovery Drug Metabolism Toxicology Clinical Research Pharmacogenomics Phrmacoinformatics Pharmacovigilance< Life Sciences like Chemistry Biomedical Sciences Microbiology Immunology Forensic Epidemiology Oncology Biomedicine Dentistry Physiotherapy Gynaecology Dermatoepidemiology Neuroscience Ophthalmology Sexology Osteology Kinesiology Angiology/Vascular Medicine Critical care Medicine Haematology Infectious Diseases and Vaccinology Bariatrics Pharmacy and Nursing Pharmacognosy and Phytochemistry Radiobiology Clinical immunology Clinical and Hospital Pharmacy Cell Biology Genomics and Proteomics Healthcare Services Healthcare Management Bioinformatics and Biotechnology Geriatric Medicine Bulletin of National Institute of Health Sciences Journal of the Austrian Society of Agricultural Economics Gongcheng Kexue Yu Jishu/Advanced Engineering Science Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery Tobacco Science and Technology Zhenkong Kexue yu Jishu Xuebao/Journal of Vacuum Science and Technology Wuhan Ligong Daxue Xuebao (Jiaotong Kexue Yu Gongcheng Ban)/Journal of Wuhan University of Technology (Transportation Science and Engineering) Zhonghua yi shi za zhi (Beijing, China : 1980) Zhongguo Shiyou Daxue Xuebao (Ziran Kexue Ban)/Journal of China University of Petroleum (Edition of Natural Science) Teikyo Medical Journal Kongzhi yu Juece/Control and Decision Changjiang Liuyu Ziyuan Yu Huanjing/Resources and Environment in the Yangtze Valley

Latest Journals

Azerbaijan Medical Journal

Agricultural Mechanization in Asia, Africa and Latin America International Medical Journal Technology Reports of Kansai University Asia Life Sciences Open Access Journals Tagliche Praxis Bulletin of National Institute of Health Sciences Journal of the Austrian Society of Agricultural Economics
Effect of esomeprazole on some liver enzymes in patients with peptic ulcer
Journal ID : AMJ-19-06-2022-10262; Author : Sarraa Dhiaa, Israa M J Al-Banaa,
Abstract :

Esomeprazole is a proton pump inhibitor (PPIs) successfully used to inhibit gastric acid secretion and treat peptic ulcers and other acid-related disorders. However, the studies of the effect of esomeprazole on liver enzymes are limited. This study aims to investigate the effect of esomeprazole on liver enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphates (ALP) in peptic ulcer patients. Twenty-nine omeprazole users and twenty-four health control were recruited from outpatient clinics. Serum levels of liver enzymes Alanine transferase (ALT), aspartate transferase (AST), and alkaline phosphates (ALP) were evaluated at least 2 months after the medication use. Serum levels of ALP (74.31± 19.63 U/L, P<0.0001) were significantly higher in esomeprazole users compared to non-users. While serum levels of ALT (16.07± 6.3 U/L, P=0.008) were significantly lower in esomeprazole users. Serum AST levels (18.86±6.4 U/L, p= 0.192) were not changed between the 2 groups. Whilst this study did not confirm the hepatotoxicity of esomeprazole on the liver, it could indicate that esomeprazole might affect the liver. Further research is required to determine whether esomeprazole is hepatotoxic or not.

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THE PROTECTIVE EFFECT OF L-CARNITINE AGAINST METHOTREXATE INDUCES HEPATIC TOXICITY IN MALE ALBINO RATS
Journal ID : AMJ-19-06-2022-10261; Author : Ahmad Shoab Karmoosh, Musab Mohammed Khalaf,
Abstract : Adverse drug reactions are increasingly challenging in medical settings; either due to their high doses or prolonged use or due to the pharmacodynamics nature of the medications. Methotrexate found applications for different ailments making their adverse effects common. It's worth trying to prevent or mitigate these adverse effects of methotrexate using available remedies if any. We aimed to reduce the hepatotoxic effects of methotrexate using L-carnitine compared to N-acetylcysteine as a positive control. To do so, a group of rats were exposed to methotrexate alone or in combination with L-carnitine or N-acetyl cysteine. Liver biochemical parameters and histological architecture were identified and compared with negative and positive groups. The results confirmed that L-carnitine and N-acetyl cysteine mitigated hepatic tissue injury confirmed by biochemical analysis of liver enzymes and histological study. The present study confirms the hepatoprotective effect of L-carnitine as a protective substance to reduce the adverse side effects of chemotherapeutic agents that cause oxidative tissue injury concomitant with inflammation.
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Vitamin E versus propolis as an add-on therapy to sitagliptin/metformin on uric acid level and renal function in type 2 diabetic patients
Journal ID : AMJ-17-06-2022-10253; Author : Sarraa Dhiaa, Imad A. Thanoon, Nabeel N. Fadhil,
Abstract : Nephropathy is one of the serious diabetic comorbid complications. Propolis has been used for the treatment of various illnesses due to its complex composition of various therapeutic constituents including antioxidant compounds which might help regenerate the pancreas or facilitate tissue glucose utilization or improve insulin action. The present study aimed to demonstrate a comparative renoprotective effect provided by vitamin E or propolis in the same diabetic patient sample on standard therapy of sitagliptin plus metformin therapy. To do so serum sample has been collected before (baseline) and after the addition of vitamin E (8 weeks) or propolis (8 weeks) to the patient therapy; the serum was frozen until analysis. The consecutive application of either vitamin E or propolis was carried out with a one-week washout period in-between both courses of therapy. The results demonstrate that propolis provides intensified renoprotection rate indicated by significantly (p<0.05) reducing the level of creatinine, uric acid, and urea alongside improved microalbuminuria. The study concluded that compared to vitamin E; propolis induced a positive effect on one of the major diabetic devastating complications, nephropathy. We do advise diabetic patients to add regular propolis doses to their standard therapy.
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The Potential Role of Polyol Pathway in the Development and Detection of Diabetic Nephropathy
Journal ID : AMJ-17-06-2022-10252; Author : Hend Ahmed Abass, Rayah Sulaiman Baban, Mahmood shaker Khudair,
Abstract : Type 2 diabetes mellitus (T2DM) is the major type of diabetes around the world with a diabetic nephropathy (DN) is the most common complication of this illness. Several pathways involving pro-inflammatory and polyol are activated through the course of T2DM. The current study aims to evaluate the role of sorbitol dehydrogenase (SDH), zinc, fructose and glycosyl phosphatidyl inositol high density lipoprotein binding protein 1 (GPIHBP1) in development of DN in T2DM Iraqi patients. This is a nested case control study, involved 122 patients with DN (72 patients with microalbuminuria (MA) and 50 patients with normoalbuminuria (NA)) and other age- and gender-matched 58 apparently healthy subjects. The SDH activity, fructose and Zn+2 concentration were determined using spectrophotometric assays, while enzyme linked immunosorbent assay (ELISA) was used to measure serum level of GPIHBP1. Other parameters including lipid profile, fasting blood sugar (FBS), glycated hemoglobin (HbA1c) and renal function tests were measured with standard biochemical methods. The mean serum level of SDH activity in MA and NA was 22.26±9.91U/L and 26.39±10.58 U/L, respectively with no significant difference. However, both groups differed significantly from controls (48.39±24.43 U/L). Similarly, fructose level was comparable between MA and NA groups (6.1±1.5 mg/dl and 6.75±1.54 mg/dl, respectively) and significantly lower than that of controls (10.0±2.0 mg/dl). The median level of GPIHBP1 in MA patients was (878.2 pg/ml) which was higher than that of NA group (1014.05pg/ml) and controls (1189.5 pg/ml) with significant differences. In the context of discrimination between MA and healthy control, the area under the curve (AUC) for SDH and fructose was 0.904, 95%CI= 0.853-0.954, p <0.00 and 0.931, 95%CI= 0.886-0.976, p <0.001, respectively, while in the context of discrimination between NA and healthy controls, it was 0.841, 95%CI= 0.767-0.915, p <0.001, and 0.903, 95%CI= 0.848-0.958, p <0.001, respectively. For GPIHBP1, the AUC in the context of discrimination between MA and healthy controls 0.846, 95%CI= 0.776-0.916, p <0.001; between MA and NA controls 0.773, 95%CI= 0.688-0.857, p <0.001, and between NA and healthy controls 0.762, 95%CI= 0.616-0.837, p <0.001. Diabetic nephropathy (whether normo- or microalbuminuria) is associated with elevated serum levels of TG and vLDL compared with healthy subjects. Serum level of GPIHBP1 is not only decreased in patients with DN, but also inversely associated with the severity of the disease, and can differentiate between normo- and microalbuminuria with a good sensitivity and specificity.
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Prevalence of breast cancer by core needle biopsy at Al Elwiya Maternity Teaching Hospital
Journal ID : AMJ-17-06-2022-10251; Author : KHANSAA HUSSEIN ALI, BASMA MOHAMMED ALI IBRAHIM, NAJIM ABID ISSA,
Abstract : Breast cancer (CA breast) is most common cancer in women globally. It accounts for 23 percent of cancer cases worldwide. To evaluate demographics and incidence of breast cancer in Iraqi women undergoing obstetric care at Al-Elwiya Maternity Teaching Hospital. A prospective observational research done in Breast clinic at Al-Elwiya Maternity Teaching Hospital between January 1, 2021 and January 1, 2022. Patients were women who came with a breast mass for whom a core needle biopsy revealed breast cancer. Exclusion criteria were benign breast tumors. Study extended over one-year period with total cases presented to breast clinic 3433 case, 67 cases had malignant breast cancer rate 1.95% in 2021. Mean age was 47.7±10.34 years ranged (24-75) years. Twelve cases (17.9%) were asymptomatic and diagnosed in screening visit, while 38.8% of cases had history of more than 1 year of breast complain before diagnosis. In regard to imaging, 83.3% presented with BIRAD 4 according to ultrasound, while depending on mammography 65.1% were BIRAD 4. With an expected 2.3 million new cases in 2020, accounting for 11.7% of all cancer cases, female breast cancer has now overtaken lung cancer worldwide. With 685,000 fatalities, it is sixth largest cause of cancer mortality globally. Incidence of breast cancer is increasing. Predominant breast cancer presentation in baghdad was mass. Our screening program should be made more exhaustive. Medical education regarding value of early breast cancer screening for women aged 45 to 55 (most prevalent age of presentation).
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The Pharmacologic Role of Antioxidant Property of Beta carotene in Reducing Amikacin-Induced Nephrotoxicity
Journal ID : AMJ-16-06-2022-10250; Author : Muthanna T. Khalaf, Zeina A. Althanoon,
Abstract : Nephrotoxicity is a great healthcare challenge in clinical care settings. Kidneys are subject to meteors from different chemicals, drugs, and xenobiotics; which make them susceptible to injury, among these are aminoglycoside antibiotics. A wide variety of therapeutic remedies has been used to protect kidneys against the toxicity of various drugs and chemicals including, vitamins, minerals, and herbal products. Beta carotene can decrease oxidative stress, so it can protect the kidney from the toxicity and damage induced by oxidative stress. In this study, we tried to investigate the possible ameliorative effect of beta carotene against amikacin-induced nephrotoxicity when given before and during the treatment of amikacin. Twenty-eight male albino rats were divided into five groups (seven in each group): 1-Control group (A): was intended for distilled water during the study period. 2-Amikacin group (B): were injected intraperitoneally with amikacin (150mg/kg/day) for two weeks. 3-Beta carotene group (C): were gavaged with beta carotene orally (100mg/kg/day) for 9 days. 4-Beta -carotene and amikacin group (D): were gavaged with beta carotene orally (100mg/kg/day) for 9 days alone, then injected intraperitoneally with amikacin (150mg/kg/day) and gavaged with beta carotene orally (100mg/kg/day) for two weeks. At the end of the study, animals were fasted and sacrificed, and serum was used for biochemical analysis and kidneys for histopathology. The results showed an elevation in serum MDA significantly (P < 0.005) and a reduction in T-AOC and GSH significantly (P < 0.005) in the amikacin group compared to the control group, whereas groups administered beta carotene with AMK showed significant improvement in the oxidative parameters compared to the AMK-treated group. In conclusion, beta carotene can act as a good antioxidant, preventing the expected nephrotoxicity induced by AMK.
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Device associated nosocomial infection in NICU: a prospective observational study.
Journal ID : AMJ-16-06-2022-10249; Author : Subhashree Karˡ,(1) Department of Pediatrics, SVPPGIP and SCBMCH, Cuttack., Swarupa Panda1,(1) Department of Pediatrics, SVPPGIP and SCBMCH, Cuttack., Prasant Kumar Bal2,(2) Department of Plastic surgery,SCBMCH,Cuttack., Mrigendra Nath Tudu3,(3). Department of Pediatrics, Fortis hospital, Bengaluru., Bharati Sahoo1.,(1) Department of Pediatrics, SVPPGIP and SCBMCH, Cuttack.,
Abstract : Nosocomial infections(NIs) are the most important current challenge faced by neonatal intensive care units (NICUs). Although systematic surveillance is an integral part of all approaches to decreasing NIs, the current methods for recording healthcare-associated infections in our country are grossly inadequate. To determine the prevalence and risk factors for device-associated infections in a tertiary care center in eastern India. This prospective observational study was undertaken in the NICU, Department of Pediatrics, SCB Medical College, Cuttack, and SVPPGIP, Cuttack. Neonates who stayed in the NICU for more than 48 hours and needed one or more devices (e.g. ventilator or CVL) are included in this study. They were observed for nosocomial infections. In this study, we included 630 neonates. A total of 94 neonates were found to have a nosocomial infection. The patient, days were 2516 days. During the period of study, central line days were found to be 173 days and ventilator days, 710. The prevalence of nosocomial infection was found to be 14.9%. Male babies were more likely to have nosocomial sepsis. Staphylococcus aureus was found to be the major organism. Nosocomial infection in NICU graduates who are put on several devices is an important preventable problem. The present study reveals that sepsis (LOS) and pneumonia are major device-associated infections. Staphylococcus aureus is most commonly associated with E. coli and Klebsiella. Their prevention can be achieved by applying strict protocols for sepsis.
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Impact of vitamin D3 supplement on some biochemical markers in patients with dental implant
Journal ID : AMJ-15-06-2022-10247; Author : Omer W. Salih, Faehaa A. Al-Mashhadane, Rayan S. Hamed,
Abstract : To investigate the effects of systemic supplementation with vitamin D3 on serum Vitamin D3, alkaline phosphatase, serum CRP and serum calcium in patients treated with dental implants. Twelve patients were classified into two groups: control group: receiving dental implants in posterior maxillary extraction sites whom did not receive any medication, and treatment group: receiving dental implants in posterior maxillary extraction sites with 1000 I/U per day oral tablet of vitamin D3 supplement for 3 months. Blood samples were collected on the 1st day of study (after the insertion of dental implant), 1 week after, and once again three months later for biochemical analysis of serum alkaline phosphatase, C-reactive protein(CPR), calcium and vitamin D3. Differences were observed between control and treatment groups throughout the 3 months of the study yet was not significant. Vitamin D supplementation has a non-significant effect on serum alkaline phosphatase, serum CRP and serum calcium in patients treated with dental implants.
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Investigation of Topical Nifedipine on Total Antioxidant Capacity and Mitochondrial Function During Facial Skin Wound Healing in Rabbits
Journal ID : AMJ-14-06-2022-10246; Author : Wasan J. Al-Dabbagh, Faehaa A. Al-Mashhadane, Ayad A. Al-Sarraj,
Abstract : The objective of this study was to evaluate the impacts of 1% and 2% topical nifedipine ointments on total antioxidant capacity and mitochondrial function during the facial skin wound healing in rabbits. Nifedipine ointments 1% and 2% were prepared. Fifty healthy male rabbits were involved and distributed into two equal group 25 of each according to study period: group A (7 days) and group B (14 days). Each group was subdivided into five groups (5 rabbits/group): group I (Normal): rabbits were not subjected to any surgical procedure or treatments; group II (negative control): rabbits had surgical wound without treatment; group III (positive control): rabbits had surgical wound, treated with white petroleum; group IV(nifedipine 1%): rabbits had surgical wound, treated with nifedipine 1% ointment; and group V(nifedipine 2%): rabbits had surgical wound, treated with nifedipine 2% ointment. Blood samples were collected from all animals after euthanasia for analysis of biochemical parameters. The results revealed a significant increase of total antioxidant capacity levels in the nifedipine 1% group on the 7th and 14th days of study in comparison to the other groups. There is no substantial variance in lactate and pyruvate levels between the normal and nifedipine 1% groups, but there is a substantial variance when compared to the other groups. Topical nifedipine 1% ointment had a beneficial effect on the wound healing process. It had superior effect on total antioxidant capacity and promoted mitochondrial function during the healing process, whereas nifedipine 2% ointment had no such effect.
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Evaluation of functional outcomes of turn down Achilles tendoplasty with bone anchoring polypropylene suture using 18G hypodermic/spinal needle for the repair of Achilles tendon injuries.
Journal ID : AMJ-14-06-2022-10245; Author : Syama Sundar Behera,Department of Burns, Plastic and Reconstructive Surgery, SCB Medical College & Hospital, Cuttack., Subrat Kumar Samantara,Department of Surgical Oncology,A.H Postgrauate Institute of Cancer, Cuttack., Subhashree Kar,Department of Pediatrics, SVPPGIP and SCBMCH, Cuttack., Prasanta Kumar Bal,Department of Burns, Plastic and Reconstructive Surgery, SCB Medical College & Hospital, Cuttack., Bibhuti Bhusan Nayak,Department of Burns, Plastic and Reconstructive Surgery, SCB Medical College & Hospital, Cuttack., Pruthwiraj Singh,Department of Burns, Plastic and Reconstructive Surgery, SCB Medical College & Hospital, Cuttack.,
Abstract : Achilles tendon rupture (ATR) presents a unique challenge to the surgeon because the gap in the Achilles tendon must be bridged by a procedure other than primary repair. Although there are numerous approaches to addressing this issue, the gastro-soleus fascial turndown flap with bone-anchoring suture or osseointegration stands out. Despite its popularity, there are few studies that have objectively evaluated the procedure's efficacy. To evaluate the efficacy of turndown flap repair with bone anchoring polypropylene suture through an 18G hypodermic/spinal needle with special reference to its various functional outcomes. This prospective observational study was conducted in the Department of Burns, Plastic, and Reconstructive Surgery, SCB Medical College & Hospital, Cuttack, for a period of two years from November 2018 to December 2020. Tendo Achilles injury patients admitted to the department due to various etiologies were considered as study samples. The difference between pre-operative and post-operative (Achilles Tendon Total Rupture Score) ATRSs was calculated. The difference between post-operative and pre-operative calf circumferences was calculated. A total of 35 patients underwent surgery for ATR. Male patients predominated. The most common cause was accidental injury in an Indian closet. The majority of patients (13, or 37.14%) presented with a gap of 4 to 5 cm between the proximal and distal segments with the ankle in a neutral position. Out of the study population, 11 patients (31%) had an ATR score difference ranging from 31–40. Thirtten patients (37.14%) had a difference ranging from 1.1 to 2 cm. Sixty percent of the cases had a good outcome. Two patients had an unsatisfactory outcome, which constituted around 5.72% of the study population. The turndown flap with bone-anchoring polypropylene suture using an 18G hypodermic/spinal needle is an effective, relatively simple, and non-time-consuming procedure with a very short learning curve and very minimal morbidity for the repair of Achilles tendon injuries with a gap (where primary repair is not possible).
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