Congenital rubella syndrome (CRS) is a group of symptomatic manifestations that affect the development of organs due to rubella infection during pregnancy. This syndrome can be prevented by vaccination which proved by elimination of Rubella and CRS in some contries whose perfomed vaccination. Based on Indonesia national program target to achieve elimination of measles-rubella and CRS by 2023, surveillance is needed to monitor the effectiveness of the rubella vaccination program. This was retrospective study used secondary data from register of CRS investigation cases and medical records in Prof. Dr. I G. N. G. Ngoerah Hospital from January 2015 to December 2021. There were a total of 315 subjects founded during study period with an average annual reporting of CRS investigation cases were 6.8 per 10,000 live births. Congenital heart disease is the most frequent manifestation of major group, while microcephaly is the most frequent manifestation of minor group in children who investigated as suspected cases of congenital rubella syndrome. The incidence of CRS per year is 0.03 per 1,000 live births. This study concluded that CRS surveillance in Prof. Dr. I. G. N. G. Ngoerah Hospital had achieved the Indonesia national target of CRS surveillance and can demonstrate the effectiveness of Rubella immunization program in Bali.