Abstract : This study described the effectiveness of pancreas omentoplasty with sleeve gastrectomy on weight reduction, improving blood sugar levels and interleukin-6 in diabetic and obese rats. A randomized control group pretest-posttest study design was performed on 12 male Wistar rats aged 6 weeks induced with obesity and type 2 diabetes mellitus (DM) and grouped into sleeve gastrectomy (SG) group (P1) and SG group with pancreatic omentoplasty (P2). SG is done by partially removing the stomach in the major curvature and suturing it. Omentoplasty is performed by suturing the omentum to the pancreas. Body weight, fasting blood glucose levels, and interleukin-6 (IL-6) were examined before and 10 days after treatment. None of the rats experienced postoperative drop-out, and examination showed that they were obese with homogeneous body weight, blood glucose, and IL-6 levels. Data analysis showed body weight, blood glucose levels, and IL-6 after treatment were significantly decreased in both groups compared to levels before treatment. The improvement of these parameters was found to be significantly better in the group that received sleeve gastrectomy and pancreatic omentoplasty. In conclusion, sleeve gastrectomy with pancreatic omentoplasty significantly reduce body weight, blood sugar levels, and IL-6 better than sleeve gastrectomy procedure alone.