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Abstract : This study aims to examine the effectiveness of polidocanol, ethanol and bleomycin as sclerosant agents in the animal model. An experimental study design was performed on 24 Lepus nigricollis rabbits (48 ears) which were divided into three treatment groups: polidocanol (group I, n=16), ethanol (group II, n=16), and bleomycin (group 3, n=16). All animals received treatment by injection into the dorsal vein behind the ear, then damming the vein 10 minutes later. After that, punch tissue samples were taken from blood vessels for 60 minutes, 24 hours, seven days, and 45 days evenly in each group for standard histopathological examination. The severity of histopathology changes was scored by inflammation, proliferation, luminal narrowing and vascular fibrosis. There were no differences in the degree of inflammation, proliferation, luminal narrowing and fibrosis in the three treatment groups with different sclerosing agents and at different times. There was a positive and significant correlation to vascular proliferation, luminal narrowing, and fibrosis over measurement time (all p<0.005). There was a positive and significant correlation to luminal narrowing and fibrosis over measurement time (all p<0.005). There was a positive and significant correlation to inflammation, luminal narrowing, and fibrosis over measurement time (all p<0.005). In conclusion, bleomycin, polidocanol, and ethanol have a similar effectivity as a sclerosing agent in vivo. However, almost histopathology changes significantly correlate with bleomycin, polidocanol, and ethanol over time.