The fact that pharmacists have an intrinsic role in health care so current efforts seek to provide a safer and more efficient learning environment by adopting a simulation-based learning. This is a cross –sectional qualitative study was conducted in Syria to investigate the perceptions of undergraduate pharmacy students regarding their learning in virtual pharmacy in Hama university by simulation method. All students of the fifth academic year 2019-2020 (100 ones) were recruited. A self- administrated questionnaire was designed and distributed to pharmacy students for collecting information regarding 1) general information and demographic data of pharmacy students, 2) opportunists provided by pharmacy students during their virtual pharmacy training, 3) students' perceptions toward simulation based learning method adopted in virtual pharmacy, 4) perception toward acquired skills in virtual pharmacy by simulation based learning and 5) weaknesses of the simulation based learning used in virtual pharmacy. A total of 80 pharmacy students responded to the questionnaire. (93.8%, n = 75) Reported having the opportunity to dispense refill or new prescriptions, virtual pharmacy improves information retention (mean = 4.59), promote integration of knowledge, skill, and behavior by students’ interaction with simulated patients (mean = 4.36), increase self-esteem (mean = 4.14). Students showed positive attitudes toward simulation-based learning in virtual pharmacy.