There is increasing evidence showing that non-communicable diseases (NCDs) are associated with morbidity among the low-income group; hence chronic disease management behavior is crucial for dealing with the diseases and improving quality of life. However, the research examined predictors for individual factors, interpersonal factors, organizational factors, community factors, and societal factors on NCD management behavior were little explored. This study aimed to examine predictor factors of NCD management behavior. This cross-sectional study was conducted among support staff in selected ministries, in Putrajaya, Malaysia using cluster sampling. An online questionnaire was used to collect the data. Data were analyzed using descriptive analysis, Pearson correlation analysis, and multiple linear regression analysis. Knowledge regarding NCD and Chronic Illness Resources Survey was used to measure individual, interpersonal, organizational, community, and societal, respectively. Results show a significant correlation between individual factors (knowledge), organizational factors (workplace), community factors (neighborhood, local community, community organization, and health services), and societal factors (health policy and mass media) with NCD management behavior. A multiple linear regression analysis revealed that societal factors, interpersonal factors, and individual factors significantly predicted NCD management behavior. Societal factors emerged as a strong predictor of NCD management behavior. Governments need to play important roles in implementing programs such as health promotion and education, as well as should be included organizational factors and community factors in these programs for improving NCD management behavior.