This article highlights the issues of studying the psychosocial rehabilitation of patients with posttraumatic stress disorder, provides findings of evidence-based medicine point of view on the need and appropriateness of the use of rehabilitation measures and the provision of psychosocial assistance to this category of patients. The study involved 38 patients of the main group with post-traumatic stress disorder (F43.1) in accordance with ICD-10 and 19 patients from the control group with a similar diagnosis, but without participation in psychosocial rehabilitation activities. Based on a detailed study and statistical analysis of patients' complaints, a general "bank" of the identified problems of psychosocial functioning in various spheres of activity was formed, the most important directions in the rehabilitation process were detected. Comparison of the main and control group results testifies in favor of the effectiveness of the developed complex system for the rehabilitation of patients with post-traumatic stress disorder (PTSD), as evidenced by the significant predominance of the recovery rate and the absence of patients with mental deterioration in the main group. The results of the study carried out according to clinical and psych diagnostic indicators show the effectiveness of the developed complex system for the rehabilitation of patients with PTSD. The research work proves that the goal of rehabilitation work in patients with PTSD is achievable only when the activity of the pathological process, the mental state of the patient, his personality, features of the immediate social environment and individual standard of living are sufficiently taken into account.