Abstract : Rheumatoid Arthritis (RA) is a chronic, systemic, autoimmune condition affecting connective tissues that is characterized by joint degeneration and inflammation, negatively affecting quality of life significantly. Joint synovitis causes severe disability by gradually destroying bones and cartilage. Rheumatoid arthritis has been identified as 42nd most significant cause of worldwide impairment and, if left untreated, even a permanent loss of function. It should be seen as a condition with symptoms outside of joints, Despite fact that it mostly affects joints, it can also cause systemic comorbidities, vasculitis, and rheumatoid nodules. Pain and stiffness in several joints are common symptoms of RA. Wrists, proximal interphalangeal joints, and proximal interphalangeal joints are all affected. most common joints affected are metacarpophalangeal joints. An inflammatory etiology is suggested by stiffness lasting longer than one hour., before emergence of clinically visible joint swelling, with more indolent arthralgias.; A low-grade fever, fatigue, and weight loss are a few possible systemic signs. Therefore, this study is aimed to determine and Measurement of sex hormones in women with RA .and a study of extent of these hormones and their relationship to types of arthritis and also severity of them among Iraqi RA patients, fifty RA patients was conducted at Rheumatology clinic of Baghdad Teaching Hospital/Medical City Complex from September 2021 to February 2022. Blood samples were obtained from all patients to investigate Complete blood count (CBC), sex hormone. We found that there is significant difference among patients of RA in distribution of Estrogen, FSH,LH, testosterone and Cortisol and progestrone levels in RA compared with control. Estrogen, LH, and FSH levels in RA (pre and post-menopause) were, significant compared with control, and also, level of this hormone in RA (per-menopause) was significant compared to patients (post-menopause). Progesterone levels were significant in RA (post-menopause) patients compared with control only progesterone, cortisol, testosterone were non -significant with control.